ID L5L0K0_PTEAL Unreviewed; 367 AA.
AC L5L0K0;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2013, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE RecName: Full=Inhibin alpha chain {ECO:0000256|ARBA:ARBA00019280, ECO:0000256|PIRNR:PIRNR037328};
GN ORFNames=PAL_GLEAN10014381 {ECO:0000313|EMBL:ELK17167.1};
OS Pteropus alecto (Black flying fox).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Megachiroptera; Pteropodidae;
OC Pteropodinae; Pteropus.
OX NCBI_TaxID=9402 {ECO:0000313|EMBL:ELK17167.1, ECO:0000313|Proteomes:UP000010552};
RN [1] {ECO:0000313|Proteomes:UP000010552}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23258410; DOI=10.1126/science.1230835;
RA Zhang G., Cowled C., Shi Z., Huang Z., Bishop-Lilly K.A., Fang X.,
RA Wynne J.W., Xiong Z., Baker M.L., Zhao W., Tachedjian M., Zhu Y., Zhou P.,
RA Jiang X., Ng J., Yang L., Wu L., Xiao J., Feng Y., Chen Y., Sun X.,
RA Zhang Y., Marsh G.A., Crameri G., Broder C.C., Frey K.G., Wang L.F.,
RA Wang J.;
RT "Comparative analysis of bat genomes provides insight into the evolution of
RT flight and immunity.";
RL Science 339:456-460(2013).
CC -!- FUNCTION: Inhibins and activins inhibit and activate, respectively, the
CC secretion of follitropin by the pituitary gland. Inhibins/activins are
CC involved in regulating a number of diverse functions such as
CC hypothalamic and pituitary hormone secretion, gonadal hormone
CC secretion, germ cell development and maturation, erythroid
CC differentiation, insulin secretion, nerve cell survival, embryonic
CC axial development or bone growth, depending on their subunit
CC composition. {ECO:0000256|PIRNR:PIRNR037328}.
CC -!- SUBUNIT: Dimeric, linked by one or more disulfide bonds. Inhibin A is a
CC dimer of alpha and beta-A. Inhibin B is a dimer of alpha and beta-B.
CC {ECO:0000256|ARBA:ARBA00011767}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the TGF-beta family.
CC {ECO:0000256|ARBA:ARBA00006656, ECO:0000256|RuleBase:RU000354}.
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DR EMBL; KB030407; ELK17167.1; -; Genomic_DNA.
DR RefSeq; XP_006906741.1; XM_006906679.2.
DR AlphaFoldDB; L5L0K0; -.
DR STRING; 9402.L5L0K0; -.
DR GeneID; 102896496; -.
DR KEGG; pale:102896496; -.
DR CTD; 3623; -.
DR eggNOG; KOG3900; Eukaryota.
DR InParanoid; L5L0K0; -.
DR OrthoDB; 5344254at2759; -.
DR Proteomes; UP000010552; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR017175; Inhibin_asu.
DR InterPro; IPR001839; TGF-b_C.
DR InterPro; IPR015615; TGF-beta-rel.
DR InterPro; IPR017948; TGFb_CS.
DR PANTHER; PTHR11848:SF117; INHIBIN ALPHA CHAIN; 1.
DR PANTHER; PTHR11848; TGF-BETA FAMILY; 1.
DR Pfam; PF00019; TGF_beta; 1.
DR PIRSF; PIRSF037328; Inhibin_alpha_subunit; 1.
DR PRINTS; PR00669; INHIBINA.
DR SMART; SM00204; TGFB; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS00250; TGF_BETA_1; 1.
DR PROSITE; PS51362; TGF_BETA_2; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Growth factor {ECO:0000256|ARBA:ARBA00023030,
KW ECO:0000256|PIRNR:PIRNR037328}; Hormone {ECO:0000256|PIRNR:PIRNR037328};
KW Reference proteome {ECO:0000313|Proteomes:UP000010552};
KW Secreted {ECO:0000256|ARBA:ARBA00022525, ECO:0000256|PIRNR:PIRNR037328};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..367
FT /note="Inhibin alpha chain"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003969747"
FT DOMAIN 230..367
FT /note="TGF-beta family profile"
FT /evidence="ECO:0000259|PROSITE:PS51362"
SQ SEQUENCE 367 AA; 39524 MW; 46A91C2DDF0344D7 CRC64;
MLPQLPLLLL LLVVPQRVHS CHGPEVDREL VLAKVRALFL DALGPPAVTG EGGNPGVRRL
LRRHAVGGFM RRGSEPVEED VSQAILFPAT GASCEDQPAV GELAQEAEEG LFTYMFRPSQ
HTRSRQVTSA QLWFHTGLDR QATASSNSSG PLLGLLALSS KGPTAVPTSL GQAPPCWAVL
HMAASALPLL THPVLVLLLR CPLCSCSARP ETTPFLVAHT RAKPASRGDR ARRSTPPLPW
PWSPAALRLL QRPPEEPAAH AHCHRAALNI SFQELGWDQW IVHPPSFVFH YCHGGCGLPT
QSDLPLPVSG VPPTPVQPFS LVPGAQPCCA ALPGTMRPLR VRTTSDGGYS FKYETVPNLL
TQHCACI
//
