ID L5L0U4_PTEAL Unreviewed; 759 AA.
AC L5L0U4;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2013, sequence version 1.
DT 24-JAN-2024, entry version 36.
DE SubName: Full=Tight junction protein ZO-1 {ECO:0000313|EMBL:ELK16871.1};
GN ORFNames=PAL_GLEAN10004719 {ECO:0000313|EMBL:ELK16871.1};
OS Pteropus alecto (Black flying fox).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Megachiroptera; Pteropodidae;
OC Pteropodinae; Pteropus.
OX NCBI_TaxID=9402 {ECO:0000313|EMBL:ELK16871.1, ECO:0000313|Proteomes:UP000010552};
RN [1] {ECO:0000313|Proteomes:UP000010552}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23258410; DOI=10.1126/science.1230835;
RA Zhang G., Cowled C., Shi Z., Huang Z., Bishop-Lilly K.A., Fang X.,
RA Wynne J.W., Xiong Z., Baker M.L., Zhao W., Tachedjian M., Zhu Y., Zhou P.,
RA Jiang X., Ng J., Yang L., Wu L., Xiao J., Feng Y., Chen Y., Sun X.,
RA Zhang Y., Marsh G.A., Crameri G., Broder C.C., Frey K.G., Wang L.F.,
RA Wang J.;
RT "Comparative analysis of bat genomes provides insight into the evolution of
RT flight and immunity.";
RL Science 339:456-460(2013).
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DR EMBL; KB030428; ELK16871.1; -; Genomic_DNA.
DR STRING; 9402.L5L0U4; -.
DR InParanoid; L5L0U4; -.
DR Proteomes; UP000010552; Unassembled WGS sequence.
DR GO; GO:0005923; C:bicellular tight junction; IEA:InterPro.
DR CDD; cd00992; PDZ_signaling; 3.
DR CDD; cd12026; SH3_ZO-1; 1.
DR Gene3D; 2.30.42.10; -; 3.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR005417; ZO.
DR InterPro; IPR005418; ZO-1.
DR InterPro; IPR035597; ZO-1_SH3.
DR PANTHER; PTHR13865; TIGHT JUNCTION PROTEIN; 1.
DR PANTHER; PTHR13865:SF25; TIGHT JUNCTION PROTEIN ZO-1; 1.
DR Pfam; PF00595; PDZ; 3.
DR Pfam; PF07653; SH3_2; 1.
DR PRINTS; PR01597; ZONOCCLUDNS.
DR PRINTS; PR01598; ZONOCCLUDNS1.
DR SMART; SM00228; PDZ; 3.
DR SUPFAM; SSF50156; PDZ domain-like; 3.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50106; PDZ; 3.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000010552};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..759
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003969713"
FT DOMAIN 38..124
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 200..278
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 435..516
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 530..598
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 117..204
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 292..429
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 695..759
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 148..185
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 186..200
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 312..340
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 372..389
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 744..759
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 759 AA; 83161 MW; 40DF3E36DC86CF7B CRC64;
MALDNSHFQR LLLALAVTVR AAESLPWAQE RSGLGKGTLH IEAPGFGFGI AISGGRDNPH
FQSGETSIVI SDVLKGGPAE GQLQENDRVA MVNGVSMDDV EHAFAVQQLR RSGKTAKITI
RRKKKVQIPV SRPDPEPASE NEEDSYDEDV HEPRGGRAGV AQRRSEKSWA RDRSASRDRS
LSPRSDRRSV ASSQPAKPTK VTLVKSRKNE EYGLRLASHI FVKEISQDSL AARDGNIQEG
DVVLKINGTV TENMSLTDAK TLIERSKGKL KMVVQRDERA TLLNVPDLSD SIHSANASER
DDISEIQSLA SDHSGRSHDR PPRHSRSRSP DQRSEPSDHS RHSPQQPSNG SLRSREEERV
SKPGTVSTPV KHAEDHAPKT AEEVTAERSE KQAPSLPEPK PVYAQVGQPD VDLPVSPSDG
VLPNSTHEDG ILRPSMKLVK FRKGDSVGLR LAGGNDVGIF VAGVLEDSPA AKEGLEEGDQ
ILRVNNVDFT NIIREEAVLF LLDLPKGEEV TILAQKKKDV YRRIVESDVG DSFYIRTHFE
YEKESPYGLS FNKGEVFRVV DTLYNGKLGS WLAIRIGKNH KEVERGIIPS KNRAEQLASV
QYTLPKTAGG DRADFWRFRG LRSSKRNXXX XGFVSSACSN QVSGLRKSCS SRRPVTIFGP
IADVAREKLA REEPDIYQIA SALWDTRATR AGHGLGFRVR KAHSAPSAPL VPAPPRQLGQ
GSVPQPPPER GGDCIRIPGP PAFVPHGARS PGSPVRPPR
//
