ID   L5L2G5_PTEAL            Unreviewed;       629 AA.
AC   L5L2G5;
DT   06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT   06-MAR-2013, sequence version 1.
DT   24-JAN-2024, entry version 40.
DE   SubName: Full=AP-1 complex subunit mu-2 {ECO:0000313|EMBL:ELK17837.1};
GN   ORFNames=PAL_GLEAN10002417 {ECO:0000313|EMBL:ELK17837.1};
OS   Pteropus alecto (Black flying fox).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Chiroptera; Megachiroptera; Pteropodidae;
OC   Pteropodinae; Pteropus.
OX   NCBI_TaxID=9402 {ECO:0000313|EMBL:ELK17837.1, ECO:0000313|Proteomes:UP000010552};
RN   [1] {ECO:0000313|Proteomes:UP000010552}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=23258410; DOI=10.1126/science.1230835;
RA   Zhang G., Cowled C., Shi Z., Huang Z., Bishop-Lilly K.A., Fang X.,
RA   Wynne J.W., Xiong Z., Baker M.L., Zhao W., Tachedjian M., Zhu Y., Zhou P.,
RA   Jiang X., Ng J., Yang L., Wu L., Xiao J., Feng Y., Chen Y., Sun X.,
RA   Zhang Y., Marsh G.A., Crameri G., Broder C.C., Frey K.G., Wang L.F.,
RA   Wang J.;
RT   "Comparative analysis of bat genomes provides insight into the evolution of
RT   flight and immunity.";
RL   Science 339:456-460(2013).
CC   -!- SIMILARITY: Belongs to the adaptor complexes medium subunit family.
CC       {ECO:0000256|ARBA:ARBA00005324}.
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DR   EMBL; KB030388; ELK17837.1; -; Genomic_DNA.
DR   AlphaFoldDB; L5L2G5; -.
DR   STRING; 9402.L5L2G5; -.
DR   eggNOG; KOG0937; Eukaryota.
DR   InParanoid; L5L2G5; -.
DR   Proteomes; UP000010552; Unassembled WGS sequence.
DR   GO; GO:0030131; C:clathrin adaptor complex; IEA:InterPro.
DR   GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR   GO; GO:0016192; P:vesicle-mediated transport; IEA:InterPro.
DR   CDD; cd14835; AP1_Mu_N; 1.
DR   Gene3D; 3.30.450.60; -; 1.
DR   Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR   Gene3D; 2.60.40.1170; Mu homology domain, subdomain B; 2.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   InterPro; IPR036168; AP2_Mu_C_sf.
DR   InterPro; IPR022775; AP_mu_sigma_su.
DR   InterPro; IPR001392; Clathrin_mu.
DR   InterPro; IPR018240; Clathrin_mu_CS.
DR   InterPro; IPR011012; Longin-like_dom_sf.
DR   InterPro; IPR028565; MHD.
DR   PANTHER; PTHR10529; AP COMPLEX SUBUNIT MU; 1.
DR   PANTHER; PTHR10529:SF234; AP-1 COMPLEX SUBUNIT MU-2; 1.
DR   Pfam; PF00928; Adap_comp_sub; 1.
DR   Pfam; PF12796; Ank_2; 1.
DR   Pfam; PF01217; Clat_adaptor_s; 1.
DR   PRINTS; PR00314; CLATHRINADPT.
DR   SMART; SM00248; ANK; 2.
DR   SUPFAM; SSF48403; Ankyrin repeat; 1.
DR   SUPFAM; SSF49447; Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor; 1.
DR   SUPFAM; SSF64356; SNARE-like; 1.
DR   PROSITE; PS50297; ANK_REP_REGION; 1.
DR   PROSITE; PS50088; ANK_REPEAT; 1.
DR   PROSITE; PS00990; CLAT_ADAPTOR_M_1; 1.
DR   PROSITE; PS00991; CLAT_ADAPTOR_M_2; 1.
DR   PROSITE; PS51072; MHD; 1.
PE   3: Inferred from homology;
KW   ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW   Reference proteome {ECO:0000313|Proteomes:UP000010552};
KW   Transport {ECO:0000256|ARBA:ARBA00022448}.
FT   DOMAIN          168..423
FT                   /note="MHD"
FT                   /evidence="ECO:0000259|PROSITE:PS51072"
FT   REPEAT          536..568
FT                   /note="ANK"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
SQ   SEQUENCE   629 AA;  69408 MW;  837294A7E0808426 CRC64;
     MSASAVFILD VKGKPLISRN YKGDVAMSEI EHFMPLLLQR EEEGALAPLL SHGRVHFLWI
     KHSNLYLVAT TLKNANASLV YSFLYKTVEV FSEYFKELEE ESIRDNFVIV YELLDELMDF
     GFPQTTDSKI LQEYITQQGN KLETGKSRVP PTVTNAVSWR SEGIKYKKNE VFIDVIESVN
     LLVNANGSVL LSEIVGTIKL KVFLSGMPEL RLGLNDRVLF ELTGLSGSKN KSVELEDVKF
     HQCVRLSRFD NDRTISFIPP DGDFELMSYR LSTQVKPLIW IESVIEKFSH SRVEIMVKAK
     GQFKKQSVAN GVEISVPVPS DADSPRFKAS VGSAKYVPEK NIVIWSIKSF PGGKEYLMRA
     HFGLPSVEKE EEEGRPPIGV KFEIPYFTVS GIQVRYMKII EKSGYQALPW VRYITQSGAP
     RDPLADRGEE PAGRVGVVLE PRTVEPGRQP CAGRVRRGRF ELASIGGLSG TDRVRVGRGA
     SQAACVNMLL EEVRAGDRLS GAAARGDVQE VMMFGSPAIA LELLKQGASP NVQDASGTTP
     AHDAARTGFL DTLKVLVEHG ADVNLPDDTG ALPIHLAVLE GHTTVVSFLA AESDLHHRDA
     RGLTPFELAQ GRGAHDLMDM LQGHTVASL
//