ID L5L5V0_PTEAL Unreviewed; 521 AA.
AC L5L5V0;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2013, sequence version 1.
DT 24-JAN-2024, entry version 42.
DE SubName: Full=Keratin, type II cytoskeletal 72 {ECO:0000313|EMBL:ELK19002.1};
GN ORFNames=PAL_GLEAN10005090 {ECO:0000313|EMBL:ELK19002.1};
OS Pteropus alecto (Black flying fox).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Megachiroptera; Pteropodidae;
OC Pteropodinae; Pteropus.
OX NCBI_TaxID=9402 {ECO:0000313|EMBL:ELK19002.1, ECO:0000313|Proteomes:UP000010552};
RN [1] {ECO:0000313|Proteomes:UP000010552}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23258410; DOI=10.1126/science.1230835;
RA Zhang G., Cowled C., Shi Z., Huang Z., Bishop-Lilly K.A., Fang X.,
RA Wynne J.W., Xiong Z., Baker M.L., Zhao W., Tachedjian M., Zhu Y., Zhou P.,
RA Jiang X., Ng J., Yang L., Wu L., Xiao J., Feng Y., Chen Y., Sun X.,
RA Zhang Y., Marsh G.A., Crameri G., Broder C.C., Frey K.G., Wang L.F.,
RA Wang J.;
RT "Comparative analysis of bat genomes provides insight into the evolution of
RT flight and immunity.";
RL Science 339:456-460(2013).
CC -!- SIMILARITY: Belongs to the intermediate filament family.
CC {ECO:0000256|RuleBase:RU000685}.
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DR EMBL; KB030275; ELK19002.1; -; Genomic_DNA.
DR RefSeq; XP_006904621.1; XM_006904559.1.
DR AlphaFoldDB; L5L5V0; -.
DR STRING; 9402.L5L5V0; -.
DR GeneID; 102880973; -.
DR KEGG; pale:102880973; -.
DR CTD; 140807; -.
DR eggNOG; ENOG502T3SC; Eukaryota.
DR InParanoid; L5L5V0; -.
DR OrthoDB; 4640531at2759; -.
DR Proteomes; UP000010552; Unassembled WGS sequence.
DR GO; GO:0045095; C:keratin filament; IEA:InterPro.
DR Gene3D; 1.20.5.170; -; 1.
DR Gene3D; 1.20.5.500; Single helix bin; 1.
DR Gene3D; 1.20.5.1160; Vasodilator-stimulated phosphoprotein; 1.
DR InterPro; IPR018039; IF_conserved.
DR InterPro; IPR039008; IF_rod_dom.
DR InterPro; IPR032444; Keratin_2_head.
DR InterPro; IPR003054; Keratin_II.
DR PANTHER; PTHR45616; GATA-TYPE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR45616:SF2; KERATIN, TYPE II CYTOSKELETAL 72; 1.
DR Pfam; PF00038; Filament; 1.
DR Pfam; PF16208; Keratin_2_head; 1.
DR PRINTS; PR01276; TYPE2KERATIN.
DR SMART; SM01391; Filament; 1.
DR SUPFAM; SSF64593; Intermediate filament protein, coiled coil region; 3.
DR PROSITE; PS00226; IF_ROD_1; 1.
DR PROSITE; PS51842; IF_ROD_2; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Intermediate filament {ECO:0000256|ARBA:ARBA00022754,
KW ECO:0000256|RuleBase:RU000685}; Keratin {ECO:0000256|ARBA:ARBA00022744};
KW Reference proteome {ECO:0000313|Proteomes:UP000010552}.
FT DOMAIN 136..449
FT /note="IF rod"
FT /evidence="ECO:0000259|PROSITE:PS51842"
FT REGION 493..521
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 205..267
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 347..427
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 502..521
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 521 AA; 56901 MW; AD865361393421C3 CRC64;
MSRQLHPYPG GERLGFSGCS TIISGRVSSS SASFRAGVKS TAAFGSRSLF NLGGGRRLAL
STSAGRGGTF ALGHCAGTGG RLGGFVGTIF GSAGLGPACP SVCPPGGIPQ VTVNKSLLAP
LNVEVDPKIQ KVRSQEREQI KALNNKFASF IDKVRFLEQQ NQVLETKWEL LQQLDLNNCK
NNLEPILEGY ISTLRKQLET LSGDRVRLDS ELRTMQDLVE DYKKRYEVEI HRRTAAENEF
VVLKKDVDAA YMNKVELQAK VDSLTDEIKF FKCLYEGEIA QIQSHISDTS VILSMDNNRD
LDLDSIINEV RAQYEEIALK SKAEAEALYQ SKIQELQVTA GQHGDDLKLT KAEISELNRL
IQRIRSEIGS VKKQCSNLET AIADAEQRGD CALKDARAKL DELEAALHQA KEELGRMLRE
YQELMSTKLA LDVEIATYRK LLEGEECRMS GEYPNSVSIS VISNTGAGGA GFSMGFGASS
SYSYKPGAAD VKTKGSCGSE FKDPFTKTSG SSCATKKKAS R
//
