UniProt: L5L670

Database: UniProt
Entry: L5L670_PTEAL

LinkDB:  L5L670_PTEAL 
Original site:  L5L670_PTEAL

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Ontology (8)   
   GO (8)   
DNA sequence (1)   
   EMBL (1)   
Protein domain (39)   
   InterPro (19)   
   Pfam (10)   
   PROSITE (4)   
   SMART (6)   
Literature (1)   
   PubMed (1)   
All databases (49)   

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ID   L5L670_PTEAL            Unreviewed;      1925 AA.
AC   L5L670;
DT   06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT   06-MAR-2013, sequence version 1.
DT   27-MAR-2024, entry version 46.
DE   SubName: Full=Complement C4-A {ECO:0000313|EMBL:ELK18900.1};
GN   ORFNames=PAL_GLEAN10001061 {ECO:0000313|EMBL:ELK18900.1};
OS   Pteropus alecto (Black flying fox).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Chiroptera; Megachiroptera; Pteropodidae;
OC   Pteropodinae; Pteropus.
OX   NCBI_TaxID=9402 {ECO:0000313|EMBL:ELK18900.1, ECO:0000313|Proteomes:UP000010552};
RN   [1] {ECO:0000313|Proteomes:UP000010552}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=23258410; DOI=10.1126/science.1230835;
RA   Zhang G., Cowled C., Shi Z., Huang Z., Bishop-Lilly K.A., Fang X.,
RA   Wynne J.W., Xiong Z., Baker M.L., Zhao W., Tachedjian M., Zhu Y., Zhou P.,
RA   Jiang X., Ng J., Yang L., Wu L., Xiao J., Feng Y., Chen Y., Sun X.,
RA   Zhang Y., Marsh G.A., Crameri G., Broder C.C., Frey K.G., Wang L.F.,
RA   Wang J.;
RT   "Comparative analysis of bat genomes provides insight into the evolution of
RT   flight and immunity.";
RL   Science 339:456-460(2013).
CC   -!- SUBCELLULAR LOCATION: Cell projection, axon
CC       {ECO:0000256|ARBA:ARBA00004489}. Cell projection, dendrite
CC       {ECO:0000256|ARBA:ARBA00004279}. Secreted
CC       {ECO:0000256|ARBA:ARBA00004613}. Synapse
CC       {ECO:0000256|ARBA:ARBA00034103}.
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DR   EMBL; KB030277; ELK18900.1; -; Genomic_DNA.
DR   STRING; 9402.L5L670; -.
DR   MEROPS; I39.951; -.
DR   eggNOG; KOG1366; Eukaryota.
DR   InParanoid; L5L670; -.
DR   Proteomes; UP000010552; Unassembled WGS sequence.
DR   GO; GO:0030424; C:axon; IEA:UniProtKB-SubCell.
DR   GO; GO:0030425; C:dendrite; IEA:UniProtKB-SubCell.
DR   GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR   GO; GO:0045202; C:synapse; IEA:UniProtKB-SubCell.
DR   GO; GO:0004866; F:endopeptidase inhibitor activity; IEA:InterPro.
DR   GO; GO:0006958; P:complement activation, classical pathway; IEA:UniProtKB-KW.
DR   GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
DR   GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR   CDD; cd00017; ANATO; 1.
DR   CDD; cd02896; complement_C3_C4_C5; 1.
DR   CDD; cd03584; NTR_complement_C4; 1.
DR   Gene3D; 1.20.50.70; -; 1.
DR   Gene3D; 1.50.10.20; -; 1.
DR   Gene3D; 2.20.130.20; -; 1.
DR   Gene3D; 2.40.50.120; -; 1.
DR   Gene3D; 2.60.120.1540; -; 2.
DR   Gene3D; 2.60.40.1930; -; 2.
DR   Gene3D; 2.60.40.1940; -; 1.
DR   Gene3D; 6.20.50.160; -; 1.
DR   Gene3D; 2.60.40.690; Alpha-macroglobulin, receptor-binding domain; 1.
DR   Gene3D; 1.20.91.20; Anaphylotoxins (complement system); 1.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR   InterPro; IPR009048; A-macroglobulin_rcpt-bd.
DR   InterPro; IPR036595; A-macroglobulin_rcpt-bd_sf.
DR   InterPro; IPR011625; A2M_N_BRD.
DR   InterPro; IPR047565; Alpha-macroglob_thiol-ester_cl.
DR   InterPro; IPR011626; Alpha-macroglobulin_TED.
DR   InterPro; IPR000020; Anaphylatoxin/fibulin.
DR   InterPro; IPR018081; Anaphylatoxin_comp_syst.
DR   InterPro; IPR001840; Anaphylatoxn_comp_syst_dom.
DR   InterPro; IPR048847; C4_MG1.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR001599; Macroglobln_a2.
DR   InterPro; IPR019742; MacrogloblnA2_CS.
DR   InterPro; IPR002890; MG2.
DR   InterPro; IPR041555; MG3.
DR   InterPro; IPR001134; Netrin_domain.
DR   InterPro; IPR018933; Netrin_module_non-TIMP.
DR   InterPro; IPR018865; STK19-like.
DR   InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR   InterPro; IPR008993; TIMP-like_OB-fold.
DR   PANTHER; PTHR11412:SF86; COMPLEMENT C4-A-RELATED; 1.
DR   PANTHER; PTHR11412; MACROGLOBULIN / COMPLEMENT; 1.
DR   Pfam; PF00207; A2M; 1.
DR   Pfam; PF07703; A2M_BRD; 1.
DR   Pfam; PF07677; A2M_recep; 1.
DR   Pfam; PF01821; ANATO; 1.
DR   Pfam; PF21145; C4_MG1; 1.
DR   Pfam; PF01835; MG2; 1.
DR   Pfam; PF17791; MG3; 1.
DR   Pfam; PF01759; NTR; 1.
DR   Pfam; PF10494; Stk19; 1.
DR   Pfam; PF07678; TED_complement; 1.
DR   PRINTS; PR00004; ANAPHYLATOXN.
DR   SFLD; SFLDG01179; Complement_C3/C4_Like; 1.
DR   SMART; SM01360; A2M; 1.
DR   SMART; SM01359; A2M_N_2; 1.
DR   SMART; SM01361; A2M_recep; 1.
DR   SMART; SM00104; ANATO; 1.
DR   SMART; SM00643; C345C; 1.
DR   SMART; SM01419; Thiol-ester_cl; 1.
DR   SUPFAM; SSF49410; Alpha-macroglobulin receptor domain; 1.
DR   SUPFAM; SSF47686; Anaphylotoxins (complement system); 1.
DR   SUPFAM; SSF48239; Terpenoid cyclases/Protein prenyltransferases; 1.
DR   SUPFAM; SSF50242; TIMP-like; 1.
DR   PROSITE; PS00477; ALPHA_2_MACROGLOBULIN; 1.
DR   PROSITE; PS01177; ANAPHYLATOXIN_1; 1.
DR   PROSITE; PS01178; ANAPHYLATOXIN_2; 1.
DR   PROSITE; PS50189; NTR; 1.
PE   4: Predicted;
KW   Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW   Cleavage on pair of basic residues {ECO:0000256|ARBA:ARBA00022685};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complement pathway {ECO:0000256|ARBA:ARBA00022875};
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Immunity {ECO:0000256|ARBA:ARBA00022859};
KW   Inflammatory response {ECO:0000256|ARBA:ARBA00023198};
KW   Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW   Reference proteome {ECO:0000313|Proteomes:UP000010552};
KW   Secreted {ECO:0000256|ARBA:ARBA00022525};
KW   Signal {ECO:0000256|ARBA:ARBA00022729};
KW   Sulfation {ECO:0000256|ARBA:ARBA00022641};
KW   Synapse {ECO:0000256|ARBA:ARBA00023018};
KW   Thioester bond {ECO:0000256|ARBA:ARBA00022966}.
FT   DOMAIN          882..916
FT                   /note="Anaphylatoxin-like"
FT                   /evidence="ECO:0000259|PROSITE:PS01178"
FT   DOMAIN          1776..1923
FT                   /note="NTR"
FT                   /evidence="ECO:0000259|PROSITE:PS50189"
FT   REGION          81..100
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          1516..1543
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        84..100
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1925 AA;  212601 MW;  B2050FD6C0F47D58 CRC64;
     MSRKRQRLVP ETLGLKRWRE RGHAEADPLR GEAGSARAAV TELVGLFPRG LFEDALPPIA
     LKSQVYSLVP DRTAADRQLV RGASATDRSR TQNPQSKALQ EQGEIRIIQL GFDLDAHGII
     FTEDYKNRVR AIVLKACDGR SYAGAVQKFL ASVLPACGDL SFQQDQMTQT FGFRDTEITQ
     LVNAGVLTVR DAGSWWLAVP GAGRFIKYFV KGRQAVLSMV RKAKYRELLL SELLGRRAPA
     AVRLGLAYHV HDLIGAQLVD WLLLFSPSVV HLGVPLSVGL QLQDAPQGQV VKGSVFLRNP
     YKLNVPCSPK VDFTLTSEKD FILLNVQMHL RGAESCGLKS LLGGPEVQLV AQSPWLKNTG
     SKEIDIQGVN LLFSSRRGHL FLQTDQPIYN PGQRVRYRVF ALDQKMRPST DTITVTVENS
     HGLRVRKREV YASSSIFQDD FVIPDISEPG TWKISARFSD GPESNRSTQF EVKKYVLPNF
     EVKIIPGKPY ILIAGGILGE IQLDIQARYI YGKPVQGVAY VRFALLGENG DKTFLRGLEN
     QTKLVDGQCH ISLSKAEVQG ALAKLNMHLT DLPGLRLYVA AAIIESPGGE LEEAELTSWH
     FVSSPFSLDL SHSKRHLVPG TPFLLQVSAG SPYPATAMLT VRAPPSRSSG FLSIERLDSR
     PPRVGDSLIL NLRDVGVSGA SFSHYYYMIL SRGQIVSVNR EPRKTLTSVS VFVDHHLAPS
     FYFVAFYYHR GLPVANSLRV DVQAKACEGK LELNVDGHKE YHPGDTVKLH LLTDSPALVA
     LGAVDTALYA VGGRSHKPLD MGKVFEVMNS YNLGCGPGGG DNALQVFEAA GLAFSDGNQL
     TSARKSLSCP EEKKTRKKRN VNFQKAIFEK LGQYTSPIAK RCCQDGLTRL PMPRSCEQRV
     ARVQQLACRE PFLSCCQFAE GLRKKIRARG QVGLARALEI LQEEDLMDED DIPVRSFFPE
     NWLWRVATVD RFFQLSHLLP DSLTTWEIHG VSLSKSKGLC VATPVRLRVF REFHVHLRLP
     ISVRRFEQFE LRPVLYNYLD KNLTVSVHVS PVEGLCLAGG GGLAQQVLVP AGSARPVGFS
     VVPTTAAAVS LKVVARGSSE FPVGDAVSKV LQIQKEGAIH IEEIVYELNP LDHRSRTLEI
     PGNSDPNILP DGEFSSYVRV TASDPLDTLG SEGALSPGGL ASLLRLPQGC GEQTMVLLAP
     TLAASHYLDK TEQWNKLPPE TKDHAVDLIQ KGYMRIQQFR KTDGSYGAWL HRDSSTWLTA
     FVLKVLSLAQ EQVGGSPEKL QESTRWLLTQ QQADGSFQDP CPVIHRGMQG GLVGNDETVA
     LTAFVVIALH HGLAVFQDKN AEELKQRVET SISKANSFLG TKASAGLLGA HAAAITAYAL
     TLTKAPEDLQ NVAHNNLMAM AQETGDHLYW GSVASSQSNV VSPTLAPHSP ADPVPQAPAL
     WIETTAYGLL HLLLREGKAE MADQAAAWLT HQGGFQGGFR STQDTVITLD ALSAYWIASH
     TTEERDLNVT FNYTSRSGAK SHVLQLNNQI QGLEEELQSS SGSKINVKVG GNSKGTLKVL
     RIYNVLDMKN TTCQDLKIEV TVMGHVEYTM EANEDYEDYE DYEREILAGD DPGPLSQPVT
     PLQLFEGRRS RRRREAPKVA DEQESRVQYT VCIWRNGKVE LSGMAIADIT LLSGFHALQA
     DLEKLTSLSD RYVSHFETEG PHVLLYFDSV PTSRECVGFG AVQEVAVGLV QPASAALYDY
     YNPEHKCSVF YGAPTKSKLL STLCSADVCQ CAEGKCPRQR RALERGLLEE DGYRMKFACY
     YPRVEYGFQV KVLREDARAA FRLFETSITQ VLHFSKDAQA TAGQTRNFLV RASCRLRLEP
     GKEYLIMGLD GATHDLKGHP QYLLDSNSWI EEMPSERLCR STRQRAACAQ LHDFIQEYST
     QGCQV
//

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