ID L5L6A0_PTEAL Unreviewed; 205 AA.
AC L5L6A0;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2013, sequence version 1.
DT 24-JAN-2024, entry version 37.
DE RecName: Full=Lymphotoxin-alpha {ECO:0000256|ARBA:ARBA00018403, ECO:0000256|RuleBase:RU368120};
DE Short=LT-alpha {ECO:0000256|RuleBase:RU368120};
DE AltName: Full=TNF-beta {ECO:0000256|ARBA:ARBA00033253, ECO:0000256|RuleBase:RU368120};
DE AltName: Full=Tumor necrosis factor ligand superfamily member 1 {ECO:0000256|ARBA:ARBA00033263, ECO:0000256|RuleBase:RU368120};
GN ORFNames=PAL_GLEAN10001099 {ECO:0000313|EMBL:ELK18935.1};
OS Pteropus alecto (Black flying fox).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Megachiroptera; Pteropodidae;
OC Pteropodinae; Pteropus.
OX NCBI_TaxID=9402 {ECO:0000313|EMBL:ELK18935.1, ECO:0000313|Proteomes:UP000010552};
RN [1] {ECO:0000313|Proteomes:UP000010552}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23258410; DOI=10.1126/science.1230835;
RA Zhang G., Cowled C., Shi Z., Huang Z., Bishop-Lilly K.A., Fang X.,
RA Wynne J.W., Xiong Z., Baker M.L., Zhao W., Tachedjian M., Zhu Y., Zhou P.,
RA Jiang X., Ng J., Yang L., Wu L., Xiao J., Feng Y., Chen Y., Sun X.,
RA Zhang Y., Marsh G.A., Crameri G., Broder C.C., Frey K.G., Wang L.F.,
RA Wang J.;
RT "Comparative analysis of bat genomes provides insight into the evolution of
RT flight and immunity.";
RL Science 339:456-460(2013).
CC -!- FUNCTION: Cytokine that in its homotrimeric form binds to
CC TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM. In its heterotrimeric
CC form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by
CC lymphocytes and is cytotoxic for a wide range of tumor cells in vitro
CC and in vivo. {ECO:0000256|RuleBase:RU368120}.
CC -!- SUBUNIT: Homotrimer, and heterotrimer of either two LTB and one LTA
CC subunits or (less prevalent) two LTA and one LTB subunits. Interacts
CC with TNFRSF14. {ECO:0000256|RuleBase:RU368120}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|RuleBase:RU368120}.
CC Membrane {ECO:0000256|RuleBase:RU368120}.
CC -!- SIMILARITY: Belongs to the tumor necrosis factor family.
CC {ECO:0000256|ARBA:ARBA00008670, ECO:0000256|RuleBase:RU368120}.
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DR EMBL; KB030277; ELK18935.1; -; Genomic_DNA.
DR RefSeq; XP_006904732.1; XM_006904670.1.
DR AlphaFoldDB; L5L6A0; -.
DR STRING; 9402.L5L6A0; -.
DR GeneID; 102887880; -.
DR KEGG; pale:102887880; -.
DR CTD; 4049; -.
DR eggNOG; ENOG502S4K8; Eukaryota.
DR InParanoid; L5L6A0; -.
DR OrthoDB; 2909163at2759; -.
DR Proteomes; UP000010552; Unassembled WGS sequence.
DR GO; GO:0005615; C:extracellular space; IEA:UniProtKB-UniRule.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-UniRule.
DR GO; GO:0005164; F:tumor necrosis factor receptor binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006959; P:humoral immune response; IEA:UniProtKB-UniRule.
DR CDD; cd00184; TNF; 1.
DR Gene3D; 2.60.120.40; -; 1.
DR InterPro; IPR006053; TNF.
DR InterPro; IPR002960; TNF_beta.
DR InterPro; IPR021184; TNF_CS.
DR InterPro; IPR006052; TNF_dom.
DR InterPro; IPR008983; Tumour_necrosis_fac-like_dom.
DR PANTHER; PTHR11471:SF31; LYMPHOTOXIN-ALPHA; 1.
DR PANTHER; PTHR11471; TUMOR NECROSIS FACTOR FAMILY MEMBER; 1.
DR Pfam; PF00229; TNF; 1.
DR PRINTS; PR01234; TNECROSISFCT.
DR PRINTS; PR01236; TNFBETA.
DR SMART; SM00207; TNF; 1.
DR SUPFAM; SSF49842; TNF-like; 1.
DR PROSITE; PS00251; TNF_1; 1.
DR PROSITE; PS50049; TNF_2; 1.
PE 3: Inferred from homology;
KW Cytokine {ECO:0000256|ARBA:ARBA00022514, ECO:0000256|RuleBase:RU368120};
KW Glycoprotein {ECO:0000256|RuleBase:RU368120};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU368120};
KW Reference proteome {ECO:0000313|Proteomes:UP000010552};
KW Secreted {ECO:0000256|RuleBase:RU368120};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|RuleBase:RU368120}.
FT SIGNAL 1..34
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 35..205
FT /note="Lymphotoxin-alpha"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003969857"
FT DOMAIN 64..205
FT /note="TNF family profile"
FT /evidence="ECO:0000259|PROSITE:PS50049"
SQ SEQUENCE 205 AA; 22149 MW; 19DE66605829D733 CRC64;
MTPPGYLYLV RVCGAPLLLL LLGLLLALPP EAQGLPGVGL SPSIARTVHQ HPQNHFAQGT
FKPAAHLVGD PSTQNSLRWR ANTDRAFLRH GFSLNNNSLL VPTSGLYFVY SQVVFSGEGC
FPKATPTPLY LAHEVQLFSS QYPFHVSLLS AQKSVCPGPQ GPWVRSVYQG AVFLLTQGDQ
LSTHTDGISH LLLSPSTVFF GAFAL
//
