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Database: UniProt
Entry: L5L7K5_PTEAL
LinkDB: L5L7K5_PTEAL
Original site: L5L7K5_PTEAL 
ID   L5L7K5_PTEAL            Unreviewed;       519 AA.
AC   L5L7K5;
DT   06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT   06-MAR-2013, sequence version 1.
DT   10-MAY-2017, entry version 27.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
GN   ORFNames=PAL_GLEAN10005119 {ECO:0000313|EMBL:ELK19023.1};
OS   Pteropus alecto (Black flying fox).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Chiroptera; Megachiroptera;
OC   Pteropodidae; Pteropodinae; Pteropus.
OX   NCBI_TaxID=9402 {ECO:0000313|EMBL:ELK19023.1, ECO:0000313|Proteomes:UP000010552};
RN   [1] {ECO:0000313|Proteomes:UP000010552}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=23258410; DOI=10.1126/science.1230835;
RA   Zhang G., Cowled C., Shi Z., Huang Z., Bishop-Lilly K.A., Fang X.,
RA   Wynne J.W., Xiong Z., Baker M.L., Zhao W., Tachedjian M., Zhu Y.,
RA   Zhou P., Jiang X., Ng J., Yang L., Wu L., Xiao J., Feng Y., Chen Y.,
RA   Sun X., Zhang Y., Marsh G.A., Crameri G., Broder C.C., Frey K.G.,
RA   Wang L.F., Wang J.;
RT   "Comparative analysis of bat genomes provides insight into the
RT   evolution of flight and immunity.";
RL   Science 339:456-460(2013).
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|RuleBase:RU361132}.
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DR   EMBL; KB030275; ELK19023.1; -; Genomic_DNA.
DR   InParanoid; L5L7K5; -.
DR   Proteomes; UP000010552; Unassembled WGS sequence.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR   InterPro; IPR001696; Na_channel_asu.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF00612; IQ; 1.
DR   PRINTS; PR00170; NACHANNEL.
DR   SMART; SM00015; IQ; 1.
DR   PROSITE; PS50096; IQ; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000010552};
KW   Ion channel {ECO:0000256|RuleBase:RU361132,
KW   ECO:0000313|EMBL:ELK19023.1};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132};
KW   Reference proteome {ECO:0000313|Proteomes:UP000010552};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM     43     61       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM     73     91       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    103    123       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    160    188       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    263    286       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   DOMAIN       42    296       Ion_trans. {ECO:0000259|Pfam:PF00520}.
SQ   SEQUENCE   519 AA;  59394 MW;  06ED6A910A33150C CRC64;
     MTEEQKKYYN AMKKLGSKKP QKPIPRPLNK IQGIIFDFVT QQAFDIVIMM LICLNMVTMM
     VETDTQSKQM ENILYWINLV FVIFFTCECV LKMFALRHYY FTIGWNIFDF VVVILSIVGM
     FLADIIEKYF VSPTLFRVIR LARIGRILRL IKGAKGIRTL LFALMMSLPA LFNIGLLLFL
     VMFIFSIFGM SNFAYVKHEA GIDDMFNFET FGNSMICLFQ ITTSAGWDGL LLPILNRPPD
     CSLEKEHPGS GFKGDCGNPS VGIFFFVSYI IISFLIVVNM YIAIILENFS VATEESADPL
     SEDDFETFYE IWEKFDPDAT QFIEYCKLAD FADALEHPLR VPKPNTIELI AMDLPMVSGD
     RIHCLDILFA FTKRVLGDSG ELDILRQQME ERFVASNPSK VSYEPITTTL RRKQEEVSAV
     VLQRAYRGHL ARRGFICKKT TSNKLENGGT HREKKESTPS TASLPSYDSV TKPEKEKQQR
     AXXXXXXXXX XXXXXXXXXX XSQKTKRGQR IQVLKESKN
//
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