ID   L5L800_PTEAL            Unreviewed;       295 AA.
AC   L5L800;
DT   06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT   06-MAR-2013, sequence version 1.
DT   27-MAR-2024, entry version 44.
DE   SubName: Full=Growth/differentiation factor 15 {ECO:0000313|EMBL:ELK19188.1};
GN   ORFNames=PAL_GLEAN10006686 {ECO:0000313|EMBL:ELK19188.1};
OS   Pteropus alecto (Black flying fox).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Chiroptera; Megachiroptera; Pteropodidae;
OC   Pteropodinae; Pteropus.
OX   NCBI_TaxID=9402 {ECO:0000313|EMBL:ELK19188.1, ECO:0000313|Proteomes:UP000010552};
RN   [1] {ECO:0000313|Proteomes:UP000010552}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=23258410; DOI=10.1126/science.1230835;
RA   Zhang G., Cowled C., Shi Z., Huang Z., Bishop-Lilly K.A., Fang X.,
RA   Wynne J.W., Xiong Z., Baker M.L., Zhao W., Tachedjian M., Zhu Y., Zhou P.,
RA   Jiang X., Ng J., Yang L., Wu L., Xiao J., Feng Y., Chen Y., Sun X.,
RA   Zhang Y., Marsh G.A., Crameri G., Broder C.C., Frey K.G., Wang L.F.,
RA   Wang J.;
RT   "Comparative analysis of bat genomes provides insight into the evolution of
RT   flight and immunity.";
RL   Science 339:456-460(2013).
CC   -!- SIMILARITY: Belongs to the TGF-beta family.
CC       {ECO:0000256|ARBA:ARBA00006656, ECO:0000256|RuleBase:RU000354}.
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DR   EMBL; KB030270; ELK19188.1; -; Genomic_DNA.
DR   RefSeq; XP_006904367.1; XM_006904305.2.
DR   AlphaFoldDB; L5L800; -.
DR   STRING; 9402.L5L800; -.
DR   GeneID; 102881163; -.
DR   KEGG; pale:102881163; -.
DR   CTD; 9518; -.
DR   eggNOG; KOG3900; Eukaryota.
DR   InParanoid; L5L800; -.
DR   OrthoDB; 3015718at2759; -.
DR   Proteomes; UP000010552; Unassembled WGS sequence.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR   GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR   CDD; cd19376; TGF_beta_GDF15; 1.
DR   Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR   InterPro; IPR029034; Cystine-knot_cytokine.
DR   InterPro; IPR001839; TGF-b_C.
DR   InterPro; IPR015615; TGF-beta-rel.
DR   PANTHER; PTHR11848:SF78; GROWTH_DIFFERENTIATION FACTOR 15; 1.
DR   PANTHER; PTHR11848; TGF-BETA FAMILY; 1.
DR   Pfam; PF00019; TGF_beta; 1.
DR   SMART; SM00204; TGFB; 1.
DR   SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR   PROSITE; PS51362; TGF_BETA_2; 1.
PE   3: Inferred from homology;
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Growth factor {ECO:0000256|ARBA:ARBA00023030,
KW   ECO:0000256|RuleBase:RU000354};
KW   Reference proteome {ECO:0000313|Proteomes:UP000010552};
KW   Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           20..295
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5003970022"
FT   DOMAIN          176..295
FT                   /note="TGF-beta family profile"
FT                   /evidence="ECO:0000259|PROSITE:PS51362"
SQ   SEQUENCE   295 AA;  33397 MW;  EFC9280EDD282431 CRC64;
     MLLMLLTLSW LPWLPSGGAL SLAQEHLPAL PRPSDMHSSA NVSRFLELRK RYEDLLTRLR
     ANHSWEDSDP DLIPASRVQI LTPKLRLGPG GYLHLYIPRA NLTRGLPTAS RLHRALLKHE
     SSSWDITRPL QRQLGLGVSR APRLRLQRMP RSDRLLAASR SANLQLELHW LPRAGRERRS
     AHARTRDACP LGEGRCCHLQ SLRVSLKDLG WADWVIAPQE LDVRMCSGAC PSQFRSANMH
     AQMLMRLHRL KPDAVRAPCC VPSSYQPVVL MHRDSEGRVS LTPYDDLVAK DCHCV
//