ID   L5LGM0_MYODS            Unreviewed;      1031 AA.
AC   L5LGM0;
DT   06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT   06-MAR-2013, sequence version 1.
DT   24-JAN-2024, entry version 36.
DE   RecName: Full=RING-type E3 ubiquitin transferase {ECO:0000256|ARBA:ARBA00012483};
DE            EC=2.3.2.27 {ECO:0000256|ARBA:ARBA00012483};
GN   ORFNames=MDA_GLEAN10023178 {ECO:0000313|EMBL:ELK25026.1};
OS   Myotis davidii (David's myotis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC   Myotis.
OX   NCBI_TaxID=225400 {ECO:0000313|EMBL:ELK25026.1, ECO:0000313|Proteomes:UP000010556};
RN   [1] {ECO:0000313|Proteomes:UP000010556}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=23258410; DOI=10.1126/science.1230835;
RA   Zhang G., Cowled C., Shi Z., Huang Z., Bishop-Lilly K.A., Fang X.,
RA   Wynne J.W., Xiong Z., Baker M.L., Zhao W., Tachedjian M., Zhu Y., Zhou P.,
RA   Jiang X., Ng J., Yang L., Wu L., Xiao J., Feng Y., Chen Y., Sun X.,
RA   Zhang Y., Marsh G.A., Crameri G., Broder C.C., Frey K.G., Wang L.F.,
RA   Wang J.;
RT   "Comparative analysis of bat genomes provides insight into the evolution of
RT   flight and immunity.";
RL   Science 339:456-460(2013).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine +
CC         [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-
CC         cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.;
CC         EC=2.3.2.27; Evidence={ECO:0000256|ARBA:ARBA00000900};
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DR   EMBL; KB112367; ELK25026.1; -; Genomic_DNA.
DR   Proteomes; UP000010556; Unassembled WGS sequence.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0004842; F:ubiquitin-protein transferase activity; IEA:InterPro.
DR   CDD; cd16541; RING-HC_RNF123; 1.
DR   Gene3D; 2.60.120.920; -; 1.
DR   Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR   InterPro; IPR043136; B30.2/SPRY_sf.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR045129; RNF123/RSPRY1-like.
DR   InterPro; IPR001841; Znf_RING.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   PANTHER; PTHR13363:SF5; E3 UBIQUITIN-PROTEIN LIGASE RNF123; 1.
DR   PANTHER; PTHR13363; RING FINGER AND SRY DOMAIN-CONTAINING; 1.
DR   Pfam; PF13920; zf-C3HC4_3; 1.
DR   SMART; SM00184; RING; 1.
DR   SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR   SUPFAM; SSF57850; RING/U-box; 1.
DR   PROSITE; PS50089; ZF_RING_2; 1.
PE   4: Predicted;
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Reference proteome {ECO:0000313|Proteomes:UP000010556};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW   ProRule:PRU00175}.
FT   DOMAIN          972..1010
FT                   /note="RING-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50089"
FT   REGION          227..265
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          277..307
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1031 AA;  113513 MW;  7C8FD18BEFC87B92 CRC64;
     MASKGADMFP RKSYGLTADA EKPRVTVSAA ALGSLGGQEK GGLVLVSGTG GPSQPLALPR
     KPLNFQNLPE HLDQLLQVDS EDEESQGHVE GRLGPSTVVL DHTGGFEGLL LVDDDLLGVI
     GHSNFGTIRS TTCVYKGKWV YEVLISSQGL MQIGWCTINC RFNQEXXXXX XXXXXXXXXX
     XXXXXXXXXX XXXXDQSCPV GGGWRADSGA TWRCGCATGL PSATALSFTR VPGRGSPDLE
     VSSSRSPRMS RVRKQNRGES GSGPLAGAVL LPLLSLGPSA SQGHRAPPSL VPGGGAPSQP
     APLLPRGPRA GLCRLSVRSP PAPVVEELQV QILKLLLNNK DENGGEASRY IFLTKFRKFL
     QENASGRGNI PLLCPPEYMV CFLHRLISAL RCYWDEYTAS NPHASASEEA YVPPQVFYNG
     KVDYFDQQRL GGLLSHLRKT LKDDLASKAN ILIDPLELQA ATMDDLDEDQ EPSPTLGRAN
     RFLSTAAVTL MTPRRPLSAS EKVKMVGVSD DVNEYAMALR NTEDKLRRCP KRRKDILEEL
     TKSQKVFSEK LDHLSRRLAW VHATVYSQEK MLDIYWLLRV CLRTIEHADR TGPLFAFMPE
     FYLSVAINSY SALKNYFGPV HSMEELPGYE ETLTRLAAIL AKHFADTRIV GTDIRDSLMQ
     ALASYVCYPH SLRAVERIPE EQRVAMVRSL LAPYEQRPWA QTNWILVRLW KGCGFGYRYT
     RLPHLLKIKP EDANLPSLQK PCPSILLQQH MADLLRQDPD VAPSFLNSVL NQLNWAFSEF
     IGMIQEVGRL RVGVLMVQEI QQAVERLERN FVDTRQLKVC ATCFDLSVSL LRVLEMTVTL
     VPEVFLDPTQ PTSEMLLQRL AQFCLESVDH YPILVAVTGI LVRLLVHGPA AGTEKATSVL
     LADPCFQLRS IRYLLGHPEP PGPGTAPPAP DRNTDYISSE ELAQVEQMLA HLTSASAQAA
     AASLPTSEED LCPICYAHPI SAVFQPCGHK SCKACINQHL MNNKDCFFCK ATIESVEDWR
     AGGASNTSSA A
//