GenomeNet

Database: UniProt
Entry: L5LRR5_MYODS
LinkDB: L5LRR5_MYODS
Original site: L5LRR5_MYODS 
ID   L5LRR5_MYODS            Unreviewed;      1753 AA.
AC   L5LRR5;
DT   06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT   06-MAR-2013, sequence version 1.
DT   10-MAY-2017, entry version 31.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
GN   ORFNames=MDA_GLEAN10024222 {ECO:0000313|EMBL:ELK28168.1};
OS   Myotis davidii (David's myotis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Chiroptera; Microchiroptera;
OC   Vespertilionidae; Myotis.
OX   NCBI_TaxID=225400 {ECO:0000313|EMBL:ELK28168.1, ECO:0000313|Proteomes:UP000010556};
RN   [1] {ECO:0000313|Proteomes:UP000010556}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=23258410; DOI=10.1126/science.1230835;
RA   Zhang G., Cowled C., Shi Z., Huang Z., Bishop-Lilly K.A., Fang X.,
RA   Wynne J.W., Xiong Z., Baker M.L., Zhao W., Tachedjian M., Zhu Y.,
RA   Zhou P., Jiang X., Ng J., Yang L., Wu L., Xiao J., Feng Y., Chen Y.,
RA   Sun X., Zhang Y., Marsh G.A., Crameri G., Broder C.C., Frey K.G.,
RA   Wang L.F., Wang J.;
RT   "Comparative analysis of bat genomes provides insight into the
RT   evolution of flight and immunity.";
RL   Science 339:456-460(2013).
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|RuleBase:RU361132}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; KB109552; ELK28168.1; -; Genomic_DNA.
DR   Proteomes; UP000010556; Unassembled WGS sequence.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR   InterPro; IPR001696; Na_channel_asu.
DR   InterPro; IPR010526; Na_trans_assoc.
DR   InterPro; IPR024583; Na_trans_cytopl.
DR   Pfam; PF00520; Ion_trans; 4.
DR   Pfam; PF06512; Na_trans_assoc; 1.
DR   Pfam; PF11933; Na_trans_cytopl; 1.
DR   PRINTS; PR00170; NACHANNEL.
DR   PROSITE; PS50096; IQ; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000010556};
KW   Ion channel {ECO:0000256|RuleBase:RU361132,
KW   ECO:0000313|EMBL:ELK28168.1};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132};
KW   Reference proteome {ECO:0000313|Proteomes:UP000010556};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    104    124       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    254    281       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    614    632       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    644    667       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    724    752       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    814    837       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1059   1077       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1098   1120       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1126   1146       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1190   1210       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1280   1298       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1310   1328       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1335   1360       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1397   1425       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1501   1524       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   DOMAIN       86    288       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      361    563       Na_trans_cytopl. {ECO:0000259|Pfam:
FT                                PF11933}.
FT   DOMAIN      614    842       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      851   1052       Na_trans_assoc. {ECO:0000259|Pfam:
FT                                PF06512}.
FT   DOMAIN     1057   1265       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1279   1534       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   COILED      278    319       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1753 AA;  197635 MW;  9E223553C78C5C50 CRC64;
     MAQALLVPPG PESFRLFTRD SLAAIEKRAA EEKAKNPKRE QDNDDENKPK PNGDLEAGKN
     LPFIYGDIPP GMVSEPLEDL DPYYISLKTI VGALIQSVKK LSDVMILTVF CLSVFALIGL
     QLFMGSLRNK CLQWPPSDSA FESNTTSFSN GTMDSNGTFV NVTMSSFNWK DYIEDESHFY
     VLDEHNDPLL CGNGSDAGQC PEGYICVKAG RNPNYGYTSF DTFSWAFLSL FRLMTQDYWE
     NLYQLTLRAA GKTYMIFFVL VIFLGSFYLV NLILAVVAMA YEEQNQATLE EAEQKEAEFQ
     QMLEQLKKQQ EEAQAVAAAS AASRDFSGIG GLGELLESSS EASKLSSKSA KEWRNRRKKR
     RQREHLEGNN KGEGDRFPKS ESEDNVKRRS FLYSMDGNRL TSDKKFYSPH QSLLSIRGSL
     FSPRRNSKTS IFSFRGRAKD VGSENDFADD EHSTFEDSES RRDSLFVPHR HGERRNSNVS
     QASMSSRMVP GLPANGKMHS TVDCNGVVSL VGGPSALTSP TGQLPEGTTT ETEVRKRRLS
     SYQISMEMLE DSSGRQRAMS IASILTNTME ELEESRQKCP PCWYRFANVF LIWDCCDAWL
     KVKHLVNLIV MDPFVDLAIT ICIVLNTLFM AMEHYPMTGQ FSSVLTIGNL VFTGIFTAEM
     VLKIIAMDPY YYFQEGWNIF DGIIVSLSLM ELGLSNVEGL SVLRSFRLLR VFKLAKSWPT
     LNMLIKIIGN SVGALGNLTL VLAIIVFIFA VVGMQLFGKS YKECVCKISS DCQLPRWHMN
     DFFHSFLIVF RVLCGEWIET MWDCMEVAGQ TMCLIVFMLV MVIGNLVVLN LFLALLLSSF
     SSDNLAATDD DNEMNNLQIA VGRMQKGIDY VKSKIRDCFR KTFFRKPKVL EIQEGNKIDS
     CMSNNTGIEI SKELNYLKDG NGTTSGVGTG SSVEKYVIDE NDMSFINNPS LTVTVPIAVG
     ESDFENLNTE EFSSESELEE SKEKLNGTSS SEGSTVDVAP PREGEQAEVE PEEDLKPEAC
     FTEGCIKKFP FCQVSTEEGK GKVWWNLRKT CYSIVEHNWF ETFIVFMILL SSGALAFEDI
     YIEQRKTIKT MLEYADKVFT YIFILEMLLK WVAYGFQTYF TNAWCWLDFL IVDVSLVSLV
     ATALGYSELG AIKSLRTLRA LRPLRALSRF EGMRVVVNAL IGAIPSIMNV LLVCLIFWLI
     FSIMGVNLFA GKFYHCVNTT TGKIFEVSEV NNFSDCQALG KQARWKNVKV NFDNVGAGYL
     ALLQVNKFQG MVFDFVTRQV FDISIMILIC LNMVTMMVET DDQSKYMTLV LSRINLVFII
     LFTGEFVLKL ISLRYYYFTI GWNIFDFVVV ILSIVGMFLA ELIEKYFVSP TLFRVIRLAR
     IGRILRLIKG AKGIRTLLFA LMMSLPALFN IGLLLFLVMF IYAIFGMSNF AYVKREVGID
     DMFNFETFGN SMICLFQITT SAGWDGLLAP ILNSAPPDCD PDAIHPGSSV KGDCGNPSVG
     IFFFVSYIII SFLVVVNMYI AVILENFSVA TEESAEPLSE DDFEMFYEVW EKFDPDATQF
     IEFSKLSDFA AALDPPLLVA KPNKVQLIAM DLPMVSGDRI HCLDILFAFT KRVLGESGEM
     DALRVQMEER FMASNPSKVS YEPITTTLKR KQEEVSAAII QRNFRCYLLK QRLKKVSSKY
     NKEAIKGRVD LPIKEDMIID KLNGNSTPEK TDASSSTTSP PSYDSVTKPD KEEFEKDKPE
     KESKGKEARE NQK
//
DBGET integrated database retrieval system