ID L5LUK9_MYODS Unreviewed; 602 AA.
AC L5LUK9;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2013, sequence version 1.
DT 27-MAR-2024, entry version 56.
DE SubName: Full=Cdc42-interacting protein 4 {ECO:0000313|EMBL:ELK29752.1};
GN ORFNames=MDA_GLEAN10002722 {ECO:0000313|EMBL:ELK29752.1};
OS Myotis davidii (David's myotis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC Myotis.
OX NCBI_TaxID=225400 {ECO:0000313|EMBL:ELK29752.1, ECO:0000313|Proteomes:UP000010556};
RN [1] {ECO:0000313|Proteomes:UP000010556}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23258410; DOI=10.1126/science.1230835;
RA Zhang G., Cowled C., Shi Z., Huang Z., Bishop-Lilly K.A., Fang X.,
RA Wynne J.W., Xiong Z., Baker M.L., Zhao W., Tachedjian M., Zhu Y., Zhou P.,
RA Jiang X., Ng J., Yang L., Wu L., Xiao J., Feng Y., Chen Y., Sun X.,
RA Zhang Y., Marsh G.A., Crameri G., Broder C.C., Frey K.G., Wang L.F.,
RA Wang J.;
RT "Comparative analysis of bat genomes provides insight into the evolution of
RT flight and immunity.";
RL Science 339:456-460(2013).
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cell cortex
CC {ECO:0000256|ARBA:ARBA00004544}. Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}. Lysosome
CC {ECO:0000256|ARBA:ARBA00004371}.
CC -!- SIMILARITY: Belongs to the FNBP1 family.
CC {ECO:0000256|ARBA:ARBA00009426}.
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DR EMBL; KB107742; ELK29752.1; -; Genomic_DNA.
DR RefSeq; XP_006764387.1; XM_006764324.2.
DR AlphaFoldDB; L5LUK9; -.
DR GeneID; 102758265; -.
DR KEGG; myd:102758265; -.
DR CTD; 9322; -.
DR eggNOG; KOG3565; Eukaryota.
DR OrthoDB; 2995634at2759; -.
DR Proteomes; UP000010556; Unassembled WGS sequence.
DR GO; GO:0005938; C:cell cortex; IEA:UniProtKB-SubCell.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0005764; C:lysosome; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd07653; F-BAR_CIP4-like; 1.
DR CDD; cd11628; HR1_CIP4_FNBP1L; 1.
DR CDD; cd11911; SH3_CIP4-like; 1.
DR Gene3D; 6.10.140.470; -; 1.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR031160; F_BAR.
DR InterPro; IPR001060; FCH_dom.
DR InterPro; IPR011072; HR1_rho-bd.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR15735:SF17; CDC42-INTERACTING PROTEIN 4; 1.
DR PANTHER; PTHR15735; FCH AND DOUBLE SH3 DOMAINS PROTEIN; 1.
DR Pfam; PF00611; FCH; 1.
DR Pfam; PF00018; SH3_1; 1.
DR SMART; SM00055; FCH; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS51741; F_BAR; 1.
DR PROSITE; PS51860; REM_1; 1.
DR PROSITE; PS50002; SH3; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Coiled coil {ECO:0000256|PROSITE-ProRule:PRU01077, ECO:0000256|SAM:Coils};
KW Endocytosis {ECO:0000256|ARBA:ARBA00022583};
KW Lipid-binding {ECO:0000256|ARBA:ARBA00023121};
KW Lysosome {ECO:0000256|ARBA:ARBA00023228};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000010556};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 1..264
FT /note="F-BAR"
FT /evidence="ECO:0000259|PROSITE:PS51741"
FT DOMAIN 393..470
FT /note="REM-1"
FT /evidence="ECO:0000259|PROSITE:PS51860"
FT DOMAIN 541..602
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 281..358
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 476..537
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 124..175
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 397..474
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 289..303
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 498..513
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 602 AA; 68430 MW; 7F8BBD7DF81F0BD9 CRC64;
MDWGTELWDQ FEVIERHTQW GLDLLDRYVK FVKERTEVEQ AYAKQLRNLV KKYLPKRPAK
DDPESKFSQQ QSFVQILQEV NDFAGQRELV AENLSVHVCL ELAKYSQEMK QERKMHFQEG
RRAQQQLESG FKQLENSKRK FERDCREAEK AAQTAERLDQ DINATKADVE KAKQQAHLRS
HMAEESKNEY AAQLQRFNRD QAHFYFSQMP QIFDKLQDMD ERRATHLGAG YGLLSEAELQ
VLPIITKCLE GMKVAAAAVD SKNDSQVLIE LNKSGFARPG DVEFEDFSQP MNRTHSDSSL
GTPSDGRPEL RGPGRSRAKR WPFGKKNKPH PQPLSPLGGS LPSALPNGPP SPRSGLDPLA
ILSELSKSVK PRLASFRSFR GSRGTVVTED FSHLPPEQQR KRLQQQLEER NRELQKEIDQ
REALKKMKDV YEKTPQMGDP TSLEPQIAET LNNIERLKLE VQKYEAWLAE AESRVLSNRG
DSLSRHTRPP DPPASAPPDS SSSSNSGSQE NKESSEEPPL EEGQDTPIYT EFDEDFEESA
SPIGHCVAIY HFEGSSEGTI SMAEGEDLSL MEEDKGDGWT RVRRKQGGEG YVPTSYLRVT
LN
//
