ID L5LVP3_MYODS Unreviewed; 2677 AA.
AC L5LVP3;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2013, sequence version 1.
DT 27-MAR-2024, entry version 62.
DE SubName: Full=E3 SUMO-protein ligase RanBP2 {ECO:0000313|EMBL:ELK30137.1};
GN ORFNames=MDA_GLEAN10004208 {ECO:0000313|EMBL:ELK30137.1};
OS Myotis davidii (David's myotis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC Myotis.
OX NCBI_TaxID=225400 {ECO:0000313|EMBL:ELK30137.1, ECO:0000313|Proteomes:UP000010556};
RN [1] {ECO:0000313|Proteomes:UP000010556}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23258410; DOI=10.1126/science.1230835;
RA Zhang G., Cowled C., Shi Z., Huang Z., Bishop-Lilly K.A., Fang X.,
RA Wynne J.W., Xiong Z., Baker M.L., Zhao W., Tachedjian M., Zhu Y., Zhou P.,
RA Jiang X., Ng J., Yang L., Wu L., Xiao J., Feng Y., Chen Y., Sun X.,
RA Zhang Y., Marsh G.A., Crameri G., Broder C.C., Frey K.G., Wang L.F.,
RA Wang J.;
RT "Comparative analysis of bat genomes provides insight into the evolution of
RT flight and immunity.";
RL Science 339:456-460(2013).
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DR EMBL; KB107320; ELK30137.1; -; Genomic_DNA.
DR eggNOG; KOG0864; Eukaryota.
DR eggNOG; KOG0865; Eukaryota.
DR Proteomes; UP000010556; Unassembled WGS sequence.
DR GO; GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0003755; F:peptidyl-prolyl cis-trans isomerase activity; IEA:InterPro.
DR GO; GO:0046907; P:intracellular transport; IEA:InterPro.
DR GO; GO:0006457; P:protein folding; IEA:InterPro.
DR CDD; cd14684; RanBD1_RanBP2-like; 1.
DR CDD; cd13177; RanBD2_RanBP2-like; 1.
DR CDD; cd14685; RanBD3_RanBP2-like; 1.
DR CDD; cd13178; RanBD4_RanBP2-like; 1.
DR Gene3D; 2.40.100.10; Cyclophilin-like; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 4.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR Gene3D; 4.10.1060.10; Zinc finger, RanBP2-type; 1.
DR InterPro; IPR029000; Cyclophilin-like_dom_sf.
DR InterPro; IPR020892; Cyclophilin-type_PPIase_CS.
DR InterPro; IPR002130; Cyclophilin-type_PPIase_dom.
DR InterPro; IPR022011; IR1-M.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR000156; Ran_bind_dom.
DR InterPro; IPR045255; RanBP1-like.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR InterPro; IPR001876; Znf_RanBP2.
DR InterPro; IPR036443; Znf_RanBP2_sf.
DR PANTHER; PTHR23138:SF169; E3 SUMO-PROTEIN LIGASE RANBP2; 1.
DR PANTHER; PTHR23138; RAN BINDING PROTEIN; 1.
DR Pfam; PF12185; IR1-M; 2.
DR Pfam; PF00160; Pro_isomerase; 1.
DR Pfam; PF00638; Ran_BP1; 4.
DR Pfam; PF00641; zf-RanBP; 1.
DR PRINTS; PR00153; CSAPPISMRASE.
DR SMART; SM00160; RanBD; 4.
DR SMART; SM00028; TPR; 1.
DR SMART; SM00547; ZnF_RBZ; 1.
DR SUPFAM; SSF50891; Cyclophilin-like; 1.
DR SUPFAM; SSF50729; PH domain-like; 4.
DR SUPFAM; SSF90209; Ran binding protein zinc finger-like; 1.
DR SUPFAM; SSF48452; TPR-like; 1.
DR PROSITE; PS00170; CSA_PPIASE_1; 1.
DR PROSITE; PS50072; CSA_PPIASE_2; 1.
DR PROSITE; PS50196; RANBD1; 4.
DR PROSITE; PS50005; TPR; 1.
DR PROSITE; PS01358; ZF_RANBP2_1; 1.
DR PROSITE; PS50199; ZF_RANBP2_2; 1.
PE 4: Predicted;
KW Ligase {ECO:0000313|EMBL:ELK30137.1};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000010556};
KW TPR repeat {ECO:0000256|PROSITE-ProRule:PRU00339};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00322};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00322}.
FT REPEAT 49..82
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT DOMAIN 1083..1219
FT /note="RanBD1"
FT /evidence="ECO:0000259|PROSITE:PS50196"
FT DOMAIN 1262..1291
FT /note="RanBP2-type"
FT /evidence="ECO:0000259|PROSITE:PS50199"
FT DOMAIN 1494..1630
FT /note="RanBD1"
FT /evidence="ECO:0000259|PROSITE:PS50196"
FT DOMAIN 1791..1927
FT /note="RanBD1"
FT /evidence="ECO:0000259|PROSITE:PS50196"
FT DOMAIN 2387..2522
FT /note="RanBD1"
FT /evidence="ECO:0000259|PROSITE:PS50196"
FT DOMAIN 2543..2677
FT /note="PPIase cyclophilin-type"
FT /evidence="ECO:0000259|PROSITE:PS50072"
FT REGION 740..784
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1057..1084
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1391..1410
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1673..1706
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1758..1789
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2039..2070
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 748..779
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1067..1084
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1680..1706
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1758..1777
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2053..2067
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2677 AA; 300722 MW; CEA34346D6CB2BF5 CRC64;
MEFIFLLSID MCLKSMKGFY FAKLYYEAKE YDLAKKYIST YINVQERDPK AHRFLGLLYE
VEENIDKAVE CYKRSVELNP TQKDLVLKIA ELLCKNDVTD GRAKYWVERA AKLFPGSPAI
YKLKEQLLDC KGEDGWNKLF DLIQSELYAR PDDVYVNIRL VELYRSNKRL KDAVAHCHEA
ERNVALRSSL EWNLCVVQTL KEYLESSDKS NWQATNKDLL LAYANLMLLT LSTRDIQESR
DLLESFDGAL QSVKSCVGGN DELSAVFLEI KGHFYMHAGS LLLKMGQHSD VQWRALSELA
ALCYLIAFQV PRPKIKLIKG EGGQNLLETM AFDRLSQSGH MLLNLSRDKQ DFLKEVVESF
ANKSGQSALY DALFSGQSPK DSSFLGSDDI GNIDVQAPKI DDLARYDVGA IRAHNGSLQH
LTWLGLQWNL LPTLPAIRKW LKQLFHHLPQ ETSRLETNAP ESICILDLEV FLLGVIYNSQ
LQLKEKCSSH YNFYQPLCLP FPVCKQLYTE RQKSWWDAVC NLIHRKAIPG TSAKLRLLVQ
RDINALRGQE KHGLQPALLI HWATYLQKTG SDLNSFYDQR EYIGRSVHYW KKVLPLLKMI
KKKISIPEPT DPLFKHFHSA DIQASEIGEY EEEAHITFAI LDAVNGNIED AMTAFESIKN
VVSYWNLALI FHRKAEDIEN EAHSPEEQEE CKNYLRKTRD YLMKILDDSD SNLSVVKKLP
VPLESVKDML NSVKQQLDDY SEGGPLYKNG SLRNTDSEMK YSTPSPTKYS LSPSKSYKYS
PKAPPQWAED QNSLLKMICQ EVEAIKKEMQ ELKLNSSNLG SPHRWPTEGY GPDSVPDGYQ
GSQTFHGAPL TVATTGTSVY YSQSPAYNSQ YLLRPAANVT PTKGPVYGMN RLPPQQHIYA
YSQQMHTPPV QSTSACMFSQ EMYGPPLRFE SPATGILSPR GDDYFNYNIQ QTSTNPPLPE
PGYFTKPPVA AHASRSAESK VIEFGKTNFV QPMPGEGIRP SLTAPAHTTQ PPFKFNSNFK
SNDGDFTFSS PQVVTQPPSM TYNNSESLLG KSVFGTPAPE VANKNHEADG GSAHGDDDDD
GPHFEPVVPL PDKIEVKTGE EDEEEFFCNR AKLFRFDAES KEWKERGIGN VKILRHKTSG
KIRLLMRREQ VLKICANHYI SPDMKLTPNA GSDRSFVWHA LDYADEFPKP EQLAIRFKTP
EEAALFKCKF EEAQNILKTS GAKFSTSETS KATKSGFEGM FTKKEETCKA TKSGFEGMFT
KKEGQWDCSV CFVQNESSSL KCVACDASKP THKPNPEASS AFTLGSKAKL SDSSGNQVGT
GFKSNFSEKA FKFGITEQGF KFGHMDQENT PSFTFQSSNT DSNSTIEGFN FSVPVLADGF
KFGIQELGNQ EKKSEKPLEN DNDFQAQGVS SQKNDTGVVF GQTGSTFTFA DLAKSTSGEG
FQFGKKDPNF KGFSGAGEKL FSLQSGKKAD KADTSTDIEK DDDAYKTEDS DDIHFEPVVQ
MPEKVELVTG EEDEKVLYSQ RVKLFRFDAE ISQWKERGLG NLKILKNEVN GKLRMLMRRE
QVLKVCANHW ITTTMNLKPL SGSDRAWMWL ASDFSDGDAK LEQLAAKFKT PELAEEFKQK
FEECQRLLLD IPLQTPHKLV DTGRAAKLIQ RAEEMKSGLK DFKTVLTNDQ TKVTEEESKN
SDAGAVSVSD ITTKPNPENT GPTVEWSNYD LREDALDDSV SSSSVHASPL ASSPVRKNLF
RFGESTTGFN FSFKSALSPS KSPALLNQSG TTVGNDEESD VTQEEERDGQ YFEPVVPLPD
LVEVSSGEEN EQVVFSHRAK LYRYDKDVGQ WKERGIGDIK ILQNYDNKQV RIVMRRDQVL
KLCANHRITP DMTLQNMKGT ERVWVWTACD FADGERKVEH LAVRFKLQDV ADSFKKIFDE
AKIAQEKDSL ITPHVSFSTT PRESPCGRIA VAVLEETTKE RTDLLQGDDI ADATSEVGDV
SSTSEIATKA VVSPPKFVFG SESVKSIFGS EKSKPFTFGN SSATGSLFGF SFNAPLKTSE
TSSGVQSGSE REVEPNNCEE SKNSDIKQSP DGKVQNLFAA FPKEEFSTNY TFKTPEKAKE
KIKPEDPPSD EDVLIVYELT PTPEHRALAS KLKLPPTFFC YKNRPDYVSE EEEDDEDFET
AVKKLNGKLY LDDSEKYKPL EKSVTENEKE CIIVWEKKPT VEEKAKADTL KLPPTFFCGV
GSDTDEDNGN GEDFQSELQK VQEAQKSHNE EITSMADSVC TGGTKVTVPF LCKSEEPDFI
TKSICSSSTF SGTVDKPVDL STRKDNDADS TSQVESKTIS FGFGNNTGLS FADLASSNSG
DFAFGSKDKN FQWANTGATV FGTQSTNKVG EEEDGSDEEV VYNEDIHFEP IVSLPEVEVK
SGEEDEEILF KERAKLYRWD RDVNQWKERG VGDIKILWHT LKNYYRILMR RDQVFKVCAN
HVITKTMELK PLNVSNNALV WTASDYADGE AKVEQLAVRF KTKEMADCFK RKFEECQQNL
LKLQKGQVSL TAELSKETNP VVFFDVCADD EPLGRITMEL FSNIVPQTAE NFRALCTGEK
GFGFKNSIFH RVIPDFVCQG GDITKHDGTG GRSIYGDKFE DENFNLARHL DYVQMHTNTS
DMPQTKVRSY PSGVDHPGEP SIWLDATCTR DAVVTRQ
//
