ID L5LXM2_MYODS Unreviewed; 1007 AA.
AC L5LXM2;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2013, sequence version 1.
DT 24-JAN-2024, entry version 41.
DE SubName: Full=Zinc fingers and homeoboxes protein 3 {ECO:0000313|EMBL:ELK30213.1};
GN ORFNames=MDA_GLEAN10017191 {ECO:0000313|EMBL:ELK30213.1};
OS Myotis davidii (David's myotis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC Myotis.
OX NCBI_TaxID=225400 {ECO:0000313|EMBL:ELK30213.1, ECO:0000313|Proteomes:UP000010556};
RN [1] {ECO:0000313|Proteomes:UP000010556}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23258410; DOI=10.1126/science.1230835;
RA Zhang G., Cowled C., Shi Z., Huang Z., Bishop-Lilly K.A., Fang X.,
RA Wynne J.W., Xiong Z., Baker M.L., Zhao W., Tachedjian M., Zhu Y., Zhou P.,
RA Jiang X., Ng J., Yang L., Wu L., Xiao J., Feng Y., Chen Y., Sun X.,
RA Zhang Y., Marsh G.A., Crameri G., Broder C.C., Frey K.G., Wang L.F.,
RA Wang J.;
RT "Comparative analysis of bat genomes provides insight into the evolution of
RT flight and immunity.";
RL Science 339:456-460(2013).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PROSITE-ProRule:PRU00108, ECO:0000256|RuleBase:RU000682}.
CC -!- SIMILARITY: Belongs to the ZHX family. {ECO:0000256|ARBA:ARBA00007440}.
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DR EMBL; KB107231; ELK30213.1; -; Genomic_DNA.
DR AlphaFoldDB; L5LXM2; -.
DR eggNOG; ENOG502RC6G; Eukaryota.
DR Proteomes; UP000010556; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR CDD; cd00086; homeodomain; 4.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 5.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR024578; Homez_homeobox_dom.
DR InterPro; IPR041057; ZHX_Znf_C2H2.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR15467:SF6; ZINC FINGERS AND HOMEOBOXES PROTEIN 3; 1.
DR PANTHER; PTHR15467; ZINC-FINGERS AND HOMEOBOXES RELATED; 1.
DR Pfam; PF00046; Homeodomain; 3.
DR Pfam; PF11569; Homez; 1.
DR Pfam; PF18387; zf_C2H2_ZHX; 1.
DR SMART; SM00389; HOX; 4.
DR SMART; SM00355; ZnF_C2H2; 2.
DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 5.
DR PROSITE; PS50071; HOMEOBOX_2; 4.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Homeobox {ECO:0000256|ARBA:ARBA00023155, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00108}; Reference proteome {ECO:0000313|Proteomes:UP000010556}.
FT DOMAIN 319..362
FT /note="Homeobox"
FT /evidence="ECO:0000259|PROSITE:PS50071"
FT DOMAIN 502..552
FT /note="Homeobox"
FT /evidence="ECO:0000259|PROSITE:PS50071"
FT DOMAIN 622..670
FT /note="Homeobox"
FT /evidence="ECO:0000259|PROSITE:PS50071"
FT DOMAIN 772..822
FT /note="Homeobox"
FT /evidence="ECO:0000259|PROSITE:PS50071"
FT DNA_BIND 321..363
FT /note="Homeobox"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT DNA_BIND 504..553
FT /note="Homeobox"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT DNA_BIND 624..671
FT /note="Homeobox"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT DNA_BIND 774..823
FT /note="Homeobox"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT REGION 22..60
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 153..175
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 201..227
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 276..296
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 599..618
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 666..722
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 890..951
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 153..167
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 276..293
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 666..681
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 918..932
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1007 AA; 109204 MW; 55D900B02E8B2299 CRC64;
MASKRKSTTP CMIPVKTVAL QEASAEAQPA EALPEGPPPD LPPEAPATSS EVAQASSNTD
SAVLANGHQS TLDGYLYSCK YCDFRSQDIT QFVGHMNSEH TDFNKDPTFV CTECSFLAKT
PEGLSLHNAK CHSGEASFLW NVAKPDNHVV VEQSVPESTS TPDPLGEPST DGTDGQAEII
ITKTPIMKIM KGKAEAKKIH TLKENAPSQP VGETLPNPPA GETEAKEGDH SFVNGAVPVS
QAPTNPAKPP HTTNGPLLGT VPVLPAGIAQ FLSLQQQPPA HAQHHTHQPL PTSKSLPKVM
IPLSSIPTYN AAMDSNSFLK NSFHKFPYPT KAELCYLTVV TKYPEEQLKI WFTAQRLKQG
ISWSPEEIED ARKKMFNTVI QSVPQPTITV LNTPLVASAG NVQHLIQAAL PGHVVGQPEG
AAGGLLVTQP LMANGLQAPS SSLPLAVTSI PKQPTVAPIN TVCSNTTSAV KVVNAAQSLL
TACPSITSQA FLDASIYKNK KSHEQLSALK GSFCRNQFPG QSEVEHLTKV TGLSTREVRK
WFSDRRYHCR NLKGSRVMMP GDPSSIIIDS VPEVPFSPAS KAPEVTCIPT AATLAAHPSV
KRQSWHQTPD FTPTKYKERA PEQLRALESS FAQNPLPLDE ELDRLRTETK MTRREIDSWF
SERRKKVTTE ENTKADGSAC QEEEEAAEDE GGADEAAGDQ RVPGENGSPE VPSSHTLAER
KVSPIKINLK NLRVTEANGK SELPGLGTCD PEDDGSHKLA LQPPGKVSCK KTAQQRHLLR
QLFVQTQWPS TQDYDSIMAQ TGLPRPEVVR WFGDSRYALK NGQLKWYEDY KRGNFPPGLL
VITPGNRELL QDYYVTHKML YEEDLQGLCD KTQMSSQQVK QWFAERMGEE TRAVADTGSE
DQGPGDPAAV RKGLGDASSE VSESSESWEP SAPEASSEPC DIPSPQAGRQ LGKEPIGAIA
VLRGYGEGAP MGGHWIYCMG ASAISKIAQL LRGNWQQTSS GHKTIKG
//
