ID L5M029_MYODS Unreviewed; 3605 AA.
AC L5M029;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2013, sequence version 1.
DT 27-MAR-2024, entry version 51.
DE RecName: Full=Ryanodine receptor 1 {ECO:0000256|ARBA:ARBA00014291};
DE AltName: Full=Skeletal muscle calcium release channel {ECO:0000256|ARBA:ARBA00032969};
DE AltName: Full=Skeletal muscle ryanodine receptor {ECO:0000256|ARBA:ARBA00031197};
DE AltName: Full=Skeletal muscle-type ryanodine receptor {ECO:0000256|ARBA:ARBA00033030};
DE AltName: Full=Type 1 ryanodine receptor {ECO:0000256|ARBA:ARBA00032832};
GN ORFNames=MDA_GLEAN10002810 {ECO:0000313|EMBL:ELK32014.1};
OS Myotis davidii (David's myotis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC Myotis.
OX NCBI_TaxID=225400 {ECO:0000313|EMBL:ELK32014.1, ECO:0000313|Proteomes:UP000010556};
RN [1] {ECO:0000313|Proteomes:UP000010556}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23258410; DOI=10.1126/science.1230835;
RA Zhang G., Cowled C., Shi Z., Huang Z., Bishop-Lilly K.A., Fang X.,
RA Wynne J.W., Xiong Z., Baker M.L., Zhao W., Tachedjian M., Zhu Y., Zhou P.,
RA Jiang X., Ng J., Yang L., Wu L., Xiao J., Feng Y., Chen Y., Sun X.,
RA Zhang Y., Marsh G.A., Crameri G., Broder C.C., Frey K.G., Wang L.F.,
RA Wang J.;
RT "Comparative analysis of bat genomes provides insight into the evolution of
RT flight and immunity.";
RL Science 339:456-460(2013).
CC -!- SUBCELLULAR LOCATION: Sarcoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004326}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004326}.
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DR EMBL; KB105778; ELK32014.1; -; Genomic_DNA.
DR eggNOG; KOG2243; Eukaryota.
DR Proteomes; UP000010556; Unassembled WGS sequence.
DR GO; GO:0033017; C:sarcoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR CDD; cd12877; SPRY1_RyR; 1.
DR CDD; cd12878; SPRY2_RyR; 1.
DR CDD; cd12879; SPRY3_RyR; 1.
DR Gene3D; 1.10.490.160; -; 2.
DR Gene3D; 2.60.120.920; -; 3.
DR Gene3D; 2.80.10.50; -; 2.
DR Gene3D; 6.20.350.10; -; 1.
DR Gene3D; 1.25.10.30; IP3 receptor type 1 binding core, RIH domain; 1.
DR InterPro; IPR001870; B30.2/SPRY.
DR InterPro; IPR043136; B30.2/SPRY_sf.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR014821; Ins145_P3_rcpt.
DR InterPro; IPR036300; MIR_dom_sf.
DR InterPro; IPR016093; MIR_motif.
DR InterPro; IPR000699; RIH_dom.
DR InterPro; IPR013333; Ryan_recept.
DR InterPro; IPR015925; Ryanodine_IP3_receptor.
DR InterPro; IPR003032; Ryanodine_rcpt.
DR InterPro; IPR048581; RYDR_Jsol.
DR InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR InterPro; IPR035761; SPRY1_RyR.
DR InterPro; IPR035764; SPRY2_RyR.
DR InterPro; IPR035762; SPRY3_RyR.
DR InterPro; IPR003877; SPRY_dom.
DR PANTHER; PTHR46399; B30.2/SPRY DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR46399:SF10; RYANODINE RECEPTOR 1; 1.
DR Pfam; PF08709; Ins145_P3_rec; 1.
DR Pfam; PF02815; MIR; 1.
DR Pfam; PF01365; RYDR_ITPR; 2.
DR Pfam; PF21119; RYDR_Jsol; 1.
DR Pfam; PF02026; RyR; 4.
DR Pfam; PF00622; SPRY; 3.
DR PRINTS; PR00795; RYANODINER.
DR SMART; SM00472; MIR; 4.
DR SMART; SM00449; SPRY; 3.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 3.
DR SUPFAM; SSF100909; IP3 receptor type 1 binding core, domain 2; 1.
DR SUPFAM; SSF82109; MIR domain; 2.
DR PROSITE; PS50188; B302_SPRY; 3.
DR PROSITE; PS50919; MIR; 4.
PE 4: Predicted;
KW Calmodulin-binding {ECO:0000256|ARBA:ARBA00022860};
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Receptor {ECO:0000313|EMBL:ELK32014.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000010556};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW S-nitrosylation {ECO:0000256|ARBA:ARBA00022799};
KW Sarcoplasmic reticulum {ECO:0000256|ARBA:ARBA00022951}.
FT DOMAIN 98..153
FT /note="MIR"
FT /evidence="ECO:0000259|PROSITE:PS50919"
FT DOMAIN 160..205
FT /note="MIR"
FT /evidence="ECO:0000259|PROSITE:PS50919"
FT DOMAIN 211..265
FT /note="MIR"
FT /evidence="ECO:0000259|PROSITE:PS50919"
FT DOMAIN 271..328
FT /note="MIR"
FT /evidence="ECO:0000259|PROSITE:PS50919"
FT DOMAIN 611..827
FT /note="B30.2/SPRY"
FT /evidence="ECO:0000259|PROSITE:PS50188"
FT DOMAIN 1043..1238
FT /note="B30.2/SPRY"
FT /evidence="ECO:0000259|PROSITE:PS50188"
FT DOMAIN 1387..1600
FT /note="B30.2/SPRY"
FT /evidence="ECO:0000259|PROSITE:PS50188"
FT REGION 1338..1357
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1371..1412
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1897..1955
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2418..2440
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2856..2886
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3503..3524
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3569..3591
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1901..1948
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2856..2871
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3508..3524
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3605 AA; 404510 MW; 615125F0A30C49DE CRC64;
MGDGGEGEDE VQFLRTDDEV VLQCSATVLK EQLKLCLAAE GFGNRLCFLE PTSNAQNVPP
DLAICCFVLE QSLSVRALQE MLANTVEAGV ESSQGGGHRT LLYGHAILLR HAHSSMYLSC
LTTSRSMTDK LAFDVGLQED ATGEACWWTM HPASKQRSEG EKVRVGDDLI LVSVSSERYL
HLSTASGELQ VDASFMQTLW NMNPISSGCE EGCVTGGHVL RLFHGHMDEC LTISPADSDD
QRRLVHYEGG AVCTHARSLW RLEPLRISWS GSHLRWGQPL RIRHVTTGRY LALTEDQGLV
VVDASKAHTK ATSFCFRISK EKLDVAPKRD VEGMGPPEIK YGESLCFVQH VASGLWLTYA
APDPKALRLG VLKKKAMLHQ EGHMDDALSL TRCQQEESQA ARMIYSTAGL YNQFIKGLDS
FSGKPRGSGP PAGTALPIEG VVLSLQDLIG YFEPPSEELQ QEEKQSKLRS LRNRQSLFQE
EGMLSLVLNC IDRLNVYTTA AHFAEFAGEE AAESWKEIVN LLYELLASLI RGNRTNCALF
STNLDWLVSK LDRLEASSGI LEVLYCVLIE SPEVLNIIQE NHIKSIISLL DKHGRNHKSK
CLSLILTYHP WIPALVPYTM ISDLDLQVLD VLCSLCVCNG VAVRSNQDLI TENLLPGREL
LLQTNLINYV TSIRPNIFVG RAEGSTQYGK WYFEVMVDEV TPFLTAQATH LRVGWALTEG
YSPYPGGGEG WGGNGVGDDL YSYGFDGLHL WTGHVARPVT SPGQHLLAPE DVVSCCLDLS
VPSISFRING CPVQGVFEAF NLDGLFFPVV SFSAGVKVRF LLGGRHGEFK FLPPPGYAPC
HEAVLPRERL HLEPIKEYRR EGPRGPHLVG PSRCLSHTDF VPCPVDTVQI VLPPHLERIR
EKLAENIHEL WALTRIEQGW TYGPVRDDNK RLHPCLVNFH SLPEPERNYN LQMSGETLKT
LLALGCHVGM ADEKAEDNLK KTKLPKTYMM SNGYKPAPLD LSHVRLTPAQ TTLVDRLAEN
GHNVWARDRV AQGWSYSAVQ DIPARRNPRL VPYRLLDEAT KRSNRDSLCQ AVRTLLGYGY
NIEPPDQEPS LVESQSRWDR VRIFRAEKSY AVQSGRWYFE FEAVTTGEMR VGWARPELRP
DVELGADELA YVFNGHRGQR WHLGSEPFGR HWQSGDVVGC MIDLTENTII FTLNGEILMS
DSGSETAFRD IEIGDGFLPV CSLGPGQVGH LNLGQDVSSL RFFAICGLQE GFEPFAINMQ
RPVTTWFSKS LPQFEAVPLE HPHYEVARVD GTVDTPPCLR LTHRTWGSQN SLVEMLFLRL
SLPVQFHQHF RCTAGATPLA SPGLQPPAED EAWAAEPDTD YENLRRSAGR WGEAEAGKEG
TAKEGTPGGT LQAGAEAQPA RAENEKDATT EKNKKRGFLF KAKKAAMMTQ PPATPALPRL
PREVVPADNR DDPEIILNTT TYYYSVRVFA GQEPSCVWVG WVTPDYHQHD MNFDLTKVRA
VTVTMGDEQG NVHSSLKCSN CYMVWGGDFV SSGQQGRISH TDLVIGCLVD LATGLMTFTA
NGKESNTFFQ VEPNTKLFPA VFVLPTHQNV IQFELGKQKN IMPLSAAMFL SERKNPAPQC
PPRLEVQMLM PISWSRMPNH FLQVDTWRAG ERLGWAVECQ EPLIMMALHI PEENRCMDIL
ELSERLNLQR FHSHTLRLYR AVCALGNNRV AHALCSHVDQ AQLLHALEDA HLPGPLRAGY
YDLLISIHLE SACRSRRSML SEYIVPLTPE TRTITLFPPG KNTDNGPRRH GLPGVGITTS
LRPPHHFSPP CFVAALTATG IAEAPARLSP SIPLEALRDK ALRMLGEAVR DGGQHARDPV
GGSVEFQFVP VLKLVSTLLV MGVFGDEDVK QILKMIEPEV FTEEQEEEEE EEEEEEDEEE
KEEDEEEESQ EKEDEEKEEE ETAEEEKEGL EEGLLQMKLP ESVKLQMCHL LEYFCDRELQ
HRVESLAAFA EYYVDKLQSN QRDRYGLLMK AFTMSAAETA RRTREFRSPP QEQINMLVHF
KDGQEEEDCP LPEEIRQDLL KFHQDLLAHC GIQLEGKEEE PEEEVTLGSR LMSLLEKVRL
VKKKEEKPEE ELPAEESKPQ SLQELVSHTV VRWAQEDFVQ SPELVRAMFS LLHRQYDGLG
ELLRALPRAY TISPSSMVDT MSLLECLGQI RSLLIVQMGP QEENLMIQSI GNIMNNKVFY
QHPNLMRALG MHETVMEVMV NVLGGGESKE IRFPKMVTSC CRFLCYFCRI SRQNQRSMFD
HLSYLLENSG IGLGMQGSTP LDVAAASVID NNELALALQE QDLEKVVSYL AGCGLQSCPM
LLAKGYPDIG WNPCGGERYL DFLRFAVFVN GESVEENANV VVRLLIRKPE CFGPALRGEG
GSGLLAAIEE AIRISEDPAR DGPGVRRDRR REHFGEEPPE ENRVHLGHAI MSFYAALIDL
LGRCAPEMHL IQAGKGEALR IRAILRSLVP LDDLVGIISL PLQIPTLGKD GALVQPKMSA
SFVPDHKASM VLFLDRVYGI ENQDFLLHVL DVGFLPDMRA AASLDTATFS TTEMALALNR
YLCLAVLPLI TKCAPLFAGT EHRAIMVDSM LHTVYRLSRG RSLTKAQRDV IEDCLMALCK
YIRPSMLQHL LRRLVFDVPI LNEFAKMPLK LLTNHYERCW KYYCLPTGWA NFGITSEEEL
HLTRKLFWGI FDSLAHKKYD PELYRIAMPC LCAIAGALPP DYVDASYSSK AEKKATVDAE
GNFDPRPVET LNVIIPEKLD SFINKFAEYT HEKWAFDKIQ NNWSYGENVD EELKTHPMLR
PYKTFSEKDK EIYRWPIKES LKAMIAWEWT IEKAREGEEE KTEKKKTRKI SQSAQTYDPR
EGYNPQPPDL SGVTLSRELQ AMAEQLAENY HNTWGRKKKQ ELEAKGGGTH PLLVPYDTLT
AKEKARDREK AQELLKFLQM NGYAVTRGLK DMELDTSSIE KRFAFGFLQQ LLRWMDISQE
FIAHLEAVVS SGRVEKSPHE QEIKFFAKIL LPLINQYFTN HCLYFLSTPA KVLGSGGHAS
NKEKEMITSL FCKLAALVRH RVSLFGTDAP AVVNCLHILA RSLDARTVMK SGPEIVKAGL
RSFFESASED IEKMVENLRL GKVSQARTQV KGVGQNLTYT TVALLPVLTT LFQHIAQHQF
GDDVILDDVQ VSCYRTLCSI YSLGTTRNSY VEKLRPALGE CLACLAAAMP VAFLEPQLNE
YNAYSVYTTK SPRERAILGL PNSVEEMCPD IPVLERLMAD IGGLAESGAR YTEMPHVIEI
TLPMLCSYLP RWWERGPEVP PPTLPAGVLP PCTAVTSDHL NSLLGNILRI IVNNLGIDEA
SWMKRLAVFA QPIVSRARPE LLHSHFIPTI GRLRKRAGKV VAEEEQLRLE AKAEAEEGEL
LVRDEFSVLC RDLYALYPLL IRYVDNNRAH WLTEPNPNAE ELFRMVGEIF IYWCKSHNFK
REEQNFVVQN EINNMSFLTA DNKSKMAKSG GSDQERTKKK RRGDRYSVQT SLIVATLKKM
LPIGLNMCAP TDQDLIALAK TRYALVPAGP HSGNLPGSHS APYTKTPGAH WEPSLRTLLK
PSLGP
//
