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Database: UniProt
Entry: L5M1C4_MYODS
LinkDB: L5M1C4_MYODS
Original site: L5M1C4_MYODS 
ID   L5M1C4_MYODS            Unreviewed;      3992 AA.
AC   L5M1C4;
DT   06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT   06-MAR-2013, sequence version 1.
DT   20-DEC-2017, entry version 25.
DE   SubName: Full=Ryanodine receptor 2 {ECO:0000313|EMBL:ELK32122.1};
GN   ORFNames=MDA_GLEAN10022816 {ECO:0000313|EMBL:ELK32122.1};
OS   Myotis davidii (David's myotis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Chiroptera; Microchiroptera;
OC   Vespertilionidae; Myotis.
OX   NCBI_TaxID=225400 {ECO:0000313|EMBL:ELK32122.1, ECO:0000313|Proteomes:UP000010556};
RN   [1] {ECO:0000313|Proteomes:UP000010556}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=23258410; DOI=10.1126/science.1230835;
RA   Zhang G., Cowled C., Shi Z., Huang Z., Bishop-Lilly K.A., Fang X.,
RA   Wynne J.W., Xiong Z., Baker M.L., Zhao W., Tachedjian M., Zhu Y.,
RA   Zhou P., Jiang X., Ng J., Yang L., Wu L., Xiao J., Feng Y., Chen Y.,
RA   Sun X., Zhang Y., Marsh G.A., Crameri G., Broder C.C., Frey K.G.,
RA   Wang L.F., Wang J.;
RT   "Comparative analysis of bat genomes provides insight into the
RT   evolution of flight and immunity.";
RL   Science 339:456-460(2013).
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448}.
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DR   EMBL; KB105638; ELK32122.1; -; Genomic_DNA.
DR   Proteomes; UP000010556; Unassembled WGS sequence.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016020; C:membrane; IEA:InterPro.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   CDD; cd12877; SPRY1_RyR; 1.
DR   CDD; cd12878; SPRY2_RyR; 1.
DR   CDD; cd12879; SPRY3_RyR; 1.
DR   Gene3D; 1.25.10.30; -; 2.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR035910; IP3R_RIH_dom_sf.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR035761; SPRY1_RyR.
DR   InterPro; IPR035764; SPRY2_RyR.
DR   InterPro; IPR035762; SPRY3_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 3.
DR   Pfam; PF13833; EF-hand_8; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF49899; SSF49899; 2.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 2.
DR   PROSITE; PS50222; EF_HAND_2; 1.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000010556};
KW   Receptor {ECO:0000313|EMBL:ELK32122.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000010556};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     30       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        31   3992       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003970784.
FT   DOMAIN      100    155       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      162    209       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      217    272       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      278    341       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      343    400       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      591    801       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1017   1214       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     3666   3701       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   COILED     2975   2995       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   3992 AA;  448780 MW;  2251FAF21C7142EA CRC64;
     MTPDSHPHPG GWAPTSFLIP LMFIECFVLR AHIPVVKFTS DPEENGAHFV EWLDQVPGVP
     GAAGGSGSSQ LRKPEEASWR RWPGTEFESA VYKTAQGGGH RTLLYGHAIL LRHSNSGMYL
     CCLSTSRSST DKLAFDVGLQ EDTTGEACWW TIHPASKQRS EGEKVRVGDD LILVSVSSER
     YLHLSYGSGS GSLHVDAAFQ LTLWSVAPIS SGSEAAQGYL IGGDVLRLLH GHMDECLTVP
     SGEHGEEQRR TVHYEGGAVS VHARSLWRLE TLRVAWSGSH IRWGQPFRLR HVTTGKYLSL
     MEDKNLLLMD KEKADVKSTA FTFRSSKEKL DAGVRKEVDG MGTSEIKYGD SVCYIQHVNT
     GLWLTYQAVD VKSVRMGAIQ RKAIMHHEGH MDDGINLSRS QHEESRTARV IRSTVFLFNR
     FIRGLDALGR KAKAPPVDLP IESVSLSLRD LISYLHPPAE HLEHEDRQNR LRALKNRQNL
     FQEEGMISLV LQCVDRLHVY SSAAHFAEVA GREAGESWKS ILNSLYELLA ALIRGNRKNC
     AQFSGSLDWL VSRLERLEAS SGILEVLHCV LVESPEALNI IKEGHIKSII SLLDKHGRNH
     KVLDVLCSLC VCHGVAVRSN QHLICDNLLP GRDLLLQTRL VNHVSSMRPN IFLGVSEGSA
     QYKKWYYELM VDHTEPFVTA EATHLRVGWA STEGYSPYPG GGEEWGGNGV GDDLFSYGFD
     GLHLWAGCIA STVSSPNQHL LRTDDVISCC LDLSAPSISF RINGQPVQGM FENFNIDGLF
     FPVVSFSAGI KVRFLLGGRH GEFKFLPPPG YAPCYEAVLP KEKLKVEHSR EYKQERTYTR
     DLLGPTVALT QAAFTPVPVD TSQIVLPPHL ERIREKLAEN IHELWVMNKI ELGWQYGPVR
     DDNKRQHPCL VEFSKLPEQE RNYNLQMSLE TLKTLLALGC HVGISDEHAE ERVKKMKLPK
     NYQLTSGYKP APMDLSFIKL TPSQEAMVDR LAENAHNVWA RDRIRQGWTY GIQQDVKNRR
     NPRLVPYTLL DDRTKKSNKD SLREAVRTLL GYGYSLEAPD QDHAARAEVC SSPGERFRIF
     RAEKTYAVKA GRWYFEFEAV TAGDMRVGWS RPGCQPDQEL GCDEHAFAFD GFKAQRWHQG
     NEHYGRSWQA GDVMGCMVDM TERTMMFTLN GEILLDDSGS ELAFKDFDVG DGFIPVCSLG
     VAQVGRMNFG KDVSTLKYFT ICGLQEGYEP FAVNTNRDIT MWLSKRLPQF LQVPSNHEHI
     EVTRIDGTAD SSPCLKVTQK SFSSQNSSTD IMFYRLSMPI ECAEVFSRTA AGGLPGAGLF
     GPKSDLEDYD VDSDFEVLMK TAHGHLVPDR GDKDKEATKP EFNNHKDYAQ EKPSRLKQRF
     LLRKTKPDYS TSHSARLTED VLADDRDDYD YLMQTSTYYY SVRIFPGQEP ASVWVGWVTA
     DFHQYDTCFD LDRVRTVTVT LGDEKGKVHE SIKRSNCYMV CAGESMSPGQ VRNNNGLEIG
     CVVDAASGLL TFTANSKELS TYYQNVMPLS AGLFKSEHRN PVPQCPPRLH VQFLSHVLWS
     RMPNQFLKVD VSRVSERQGW LVQCVDPLQF MSLHIPEENR SVDILELTEQ EELLRFHSHT
     LRLYSAVCAL GNHRVAHALC SHVDEAQLLY AIESKYMPGL LRAGYYDLLI DIHLSAYATA
     RLMMNNEFIV PMTEETKSIT LFPDKHKEHG LPGIGLSTSL RPRMRFSSPS FVCLNHDCYQ
     YSPEFPLDTL KAKTMQMLTE VVQEGGLRAR DPVGGTTEFL FVPLIKLFYT LLTMGVFQGE
     DLKHILQLIE PRVFKEASLE EEHQAPLKEP HTEDARPEGI RGDAAEGLLQ MKLPEPVKLQ
     MCLLLQYLCD CQVRHRIEAI VAFSDDFVAR LQDNQRFRYN EVMQALNMSA ALTARKTKEF
     RSPPQEQNLP SGIDSMLRAC ASCLRAVVWV KAAPVKDRIE LDDDGSLDGS SDLTIRGRLL
     SLVEKVTSLK KKQADKPAES ASDKSSTLQQ LISETMVRWA QESVIEDPEL VRAMFVLLHR
     QYDGIGGLVQ ALPKTYTISA VSVEDTINLL ASLGQIRSLL SVRMGREEEK LMIRGLGDIM
     NNKVFYQHPN LMRALGMHET VMEVMVNVLG GGESKEITFP KMVANCCRFL CYFCRISRQN
     QKAMFDHLSY LLENSSVGLA SPAMRGSTPL DVAAASVMDN NELALALREP DLEKVVRYLA
     GCGLQSCPML VAKGYPDIGW NPVEGERYLD FLRFAVFCNG ESVEENANVV VRLLIRRPEC
     FGPALRGEGG NGLLAAMEEA IKIAEDPSRD GPSPTSGSSK TPDTAEEDNT IHMGNAIMTF
     YAALIDLLGR CAPEMHLIHA GKGEAIRIRS ILRSLIPLGD LVGVISITFQ MPAIAKDGNV
     VEPDMSAGFC PDHKAAMVLF LDRVYGIEVQ DFLLHLLEVG FLPDLRAAAS LDTAALSATD
     MALALNRYLC TAVLPLLTRC APLFAGTEHH ASLIDSLLHT VYRLSKGCSL TKAQRDSIEV
     CLLSICGQLR PSMMQHLLRR FVFDVPLLNE HAKMPLKKYE QELFKLALPC LSAVAGALPP
     DYMESNHVGM MEKQSSMDSE GNFNPQPVET SNITIPEKLE YFINRYAEHS HDRWSMDKLA
     NGWIYGETYS DSSKVQPLMK PYKLLSEKEK EIYRWPIKES LKTMLAWGWR IERTREGDSM
     ALYHRTRRIS QTSQVSVDAA HGYSPRAIDM SNVTLSRDLH AMAEMMAENY HNIWAKKKKM
     ELESKGGGNH PLLVPYDTLT AKEKAKDREK AQDILKFLQI NGYAVSRGFK DLELDAPTIE
     KRFAYSFLQQ LIRYVDEAHQ YILEFALNLP ANVEDVCPNI PSLEKLMEEI VELAESGIRY
     TQMPHVMEVI LPMLCSYMSR WWEQGPESNP ERAGLCCTAL NSEHMNTLLG NILKIIYNNL
     GIDEGAWMKR LAVFSQPIIN KVKPQLLKTH FLPLMEKLKK KAAVVVAEED HLKAEARGDM
     SEAELLILDE FTTLARDLYA FYPLLIRFVD YNRAKWLKEP SPEAEDLFRM VAEVFIYWSK
     SHNFKREEQN FVVQNGDPGL MSGAEQRLTP APVRLQAAVS DQERKKMRRK GDRYSVQTSL
     IVAALRRLLP IGLNICAPGD QELIALAKNR LSMKDTEDEV RDIIRSNIHL QGKLEDPAIR
     WQMALYKDLP NRPEDSADPE KTVERVLDIA SVLFHLEQVE HPQRSKKAVW HKLLSKQRKR
     AVVACFRMAP LYNLPRHRAV NLFLQGYEKS WIETEEHYFE DKLIEDLAKP GADPPEEDEG
     TKRVDPLHQL ILLFSRTALT EKCKLEEDFL YMAYADIMAK SCHDEDDDDS EEEVKSFEEK
     EMEKQKLLYQ QARLHERGAA EMVLQTISAS KGETGPMVAA TLKLGIAILN GGNSTVQQKM
     LDYLKEKKDV GFFQSLAGLM QSCSVLDLNA FERQNKAEGL GMVTEEGSGE KVLQDDEFTC
     DLFRFLQLLC EGHNSDFQNY LRTQTGNNTT VNIIISTVDY LLRVQESISD FYWYYSGKDV
     IDEQGQRNFS KAIQVAKQVF NTLTEYIQGP CTGNQQSLAH SRLWDAVVGF LHVFAHMQMK
     LSQDSSQIEL LKELMDLQKD MVVMLLSMLE GNVVNGTIGK QMVDMLVESS NNVEMILKFF
     DMFLKLKDLT SSDTFKEYDP DGKGVISKRD FHKAMESHKH YTPSETEFLL SCAETDENET
     LDYEEFVKRF HEPAKDISFN VAVLLTNLSE HMPNDSRLQT FLELAESVLR YFQPFLGRIE
     IMGSAKRIER VYFEISESSR TQWEKPQVKE SKRQFIFDVV NEGGEKEKME LFVNFCEDTI
     FEMQLAAQIS ESDLSERSAS KEESAQPADA PAPAQPEEPE EADEEGEEDD GEGHGHGALL
     LLLGGAGEPA ARGGQRAARL LPHRGQPAPG GQPGGGREED PGGGAPGRHA GPHAGRGAGR
     RGGGRAEAAG GRPALGGPHR PEGADGGERP AL
//
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