ID L5M4Y4_MYODS Unreviewed; 1436 AA.
AC L5M4Y4;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2013, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE SubName: Full=CLIP-associating protein 2 {ECO:0000313|EMBL:ELK33335.1};
GN ORFNames=MDA_GLEAN10018236 {ECO:0000313|EMBL:ELK33335.1};
OS Myotis davidii (David's myotis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC Myotis.
OX NCBI_TaxID=225400 {ECO:0000313|EMBL:ELK33335.1, ECO:0000313|Proteomes:UP000010556};
RN [1] {ECO:0000313|Proteomes:UP000010556}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23258410; DOI=10.1126/science.1230835;
RA Zhang G., Cowled C., Shi Z., Huang Z., Bishop-Lilly K.A., Fang X.,
RA Wynne J.W., Xiong Z., Baker M.L., Zhao W., Tachedjian M., Zhu Y., Zhou P.,
RA Jiang X., Ng J., Yang L., Wu L., Xiao J., Feng Y., Chen Y., Sun X.,
RA Zhang Y., Marsh G.A., Crameri G., Broder C.C., Frey K.G., Wang L.F.,
RA Wang J.;
RT "Comparative analysis of bat genomes provides insight into the evolution of
RT flight and immunity.";
RL Science 339:456-460(2013).
CC -!- SUBCELLULAR LOCATION: Chromosome, centromere, kinetochore
CC {ECO:0000256|ARBA:ARBA00004629}. Golgi apparatus, trans-Golgi network
CC {ECO:0000256|ARBA:ARBA00004601}.
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DR EMBL; KB104455; ELK33335.1; -; Genomic_DNA.
DR eggNOG; KOG2956; Eukaryota.
DR Proteomes; UP000010556; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0000776; C:kinetochore; IEA:UniProtKB-KW.
DR GO; GO:0015630; C:microtubule cytoskeleton; IEA:UniProt.
DR GO; GO:0008017; F:microtubule binding; IEA:UniProt.
DR GO; GO:0051494; P:negative regulation of cytoskeleton organization; IEA:UniProt.
DR GO; GO:1902904; P:negative regulation of supramolecular fiber organization; IEA:UniProt.
DR GO; GO:0031110; P:regulation of microtubule polymerization or depolymerization; IEA:UniProt.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 4.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR024395; CLASP_N_dom.
DR InterPro; IPR021133; HEAT_type_2.
DR InterPro; IPR034085; TOG.
DR InterPro; IPR048491; XMAP215_CLASP_TOG.
DR PANTHER; PTHR21567; CLASP; 1.
DR PANTHER; PTHR21567:SF30; CLIP-ASSOCIATING PROTEIN 2; 1.
DR Pfam; PF21040; CEP104-like_TOG; 1.
DR Pfam; PF12348; CLASP_N; 1.
DR Pfam; PF21041; XMAP215_CLASP_TOG; 1.
DR SMART; SM01349; TOG; 3.
DR SUPFAM; SSF48371; ARM repeat; 2.
DR PROSITE; PS50077; HEAT_REPEAT; 1.
PE 4: Predicted;
KW Centromere {ECO:0000256|ARBA:ARBA00023328};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Kinetochore {ECO:0000256|ARBA:ARBA00022838};
KW Reference proteome {ECO:0000313|Proteomes:UP000010556};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 1..164
FT /note="TOG"
FT /evidence="ECO:0000259|SMART:SM01349"
FT REPEAT 100..138
FT /note="HEAT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00103"
FT DOMAIN 790..1027
FT /note="TOG"
FT /evidence="ECO:0000259|SMART:SM01349"
FT DOMAIN 1193..1429
FT /note="TOG"
FT /evidence="ECO:0000259|SMART:SM01349"
FT REGION 478..532
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 569..631
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 652..721
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 760..788
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1020..1070
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1094..1137
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 478..514
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 612..631
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 652..695
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 766..788
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1100..1115
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1436 AA; 157557 MW; CD2A63CF7976ECD4 CRC64;
MGLEILSAFV DRLSTRFKSY VAMVIVALID RLGDAKDKIR DEAQILLLKL MDQVAPPMHI
WEQLASGFKH KNFRSREGVC LCLIETLNIF GAQPLVLSKL VPHLCILFGD SNSQVRDAAI
LAIVEIYRHV GEKVRMDLSK RGIPPARLEM IFAKFDEVQN SGGMILSVCK DKSFDDEESV
DGNRPSSAAS AFKVPAPKTS GNPVRFWSRA CTSVAGTSLV GSASKEGGAG AVDEEDFIKA
FTDVPSIQIY SGRELEETLN KIREILSDDK HDWDQRANAV SFLFSYPSPL FFNLPFQKHG
NSVVLLSGIS DTYEIECLIS YIFGNHLSTV LGNRFDHGAE AIVPTLFNLV PNSAKVMATS
GCAAIRFIIR HTHVPRLIPL ITSNCTSKSV PVRRRSFEFL DLLLQEWQTH SLERHAAVLV
ETIKKGIHDA DAEARVEARK TYMGLRNHFP GEAETLYNSL EPSYQKSLQT YLKSSGSVAS
LPQSDRSSSS SQESLNRPFS SKWSTANPST VAGRVAAGSS KAGSLPGSLQ RSRSDIDVNA
AAGAKAHHAA GQAMRSGRLG AGALNPGSYA SLEDTSDKMD GTASEDGRVR AKLSAPLAGI
GNAKTDSRGR SRTKMVSQSQ PGSRSGSPGR VLTTTALSTV SSGVQRVLVN SASAQKRSKI
PRSQGCSREA SPSRLSVARS SRIPRPSVSQ GCSREASRES SRDTSPVRSF QPLGPGYGIS
QSSRLSASVS AMRVLNTGSD VEEAVADALK KPARRRYESY GMHSDDDANS DASSACSERS
YSSRNGSIPT YMRQTEDVAE VLNRCASSNW SERKEGLLGL QNLLKNQRTL SRVELKRLCE
IFTRMFADPH GKVFSMFLET LVDFIQVHKD DLQDWLFVLL TQLLKKMGAD LLGSVQAKVQ
KALDITRESF PNDLQFNILM RFTVDQTQTP SLKVKVAILK YIETLAKQMD PGDFVNSSET
RLAVSRFITW TTEPKSSEVR KAAHSVLISL FELNTPEFTM LLGALPKTFQ DGATKLLHNH
LRNTGNGTQS SMGSPLTRPT PRSPANWSSP LTSPTNTSQN TLSPSAFDYD TENMNSEDIY
SSLRGVTEAI QNFSFRSQED MNEPLKRDSK KDDGDSMCGG PGMPDTRAGG DATDSSQTAL
DNKASLLHSM PAHSSPRSRD YNPYNYSDSI SPFNKSALKE AMFDDDADQF PDDLSLDHSD
LVAELLKELS NHNERVEERK IALYELMKLT QEESFSVWDE HFKTILLLLL ETLGDKEPTI
RALALKVLKE ILRHQPARFK NYAELTVMKT LEAHKDPHKE VVRSAEEAAS VLATSISPEQ
CIKVLCPIIQ TADYPINLAA IKMQTKVIER VSKETLNLLL PEIMPGLIQG YDNSESSVRK
ACVFCLVAVH AVIGDELKPH LSQLTGSKMK LLNLYIKRAQ TGSGGADPTT DVPGQS
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