ID   L5M7M6_MYODS            Unreviewed;       506 AA.
AC   L5M7M6;
DT   06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT   06-MAR-2013, sequence version 1.
DT   27-MAR-2024, entry version 36.
DE   SubName: Full=THUMP domain-containing protein 3 {ECO:0000313|EMBL:ELK34337.1};
GN   ORFNames=MDA_GLEAN10023704 {ECO:0000313|EMBL:ELK34337.1};
OS   Myotis davidii (David's myotis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC   Myotis.
OX   NCBI_TaxID=225400 {ECO:0000313|EMBL:ELK34337.1, ECO:0000313|Proteomes:UP000010556};
RN   [1] {ECO:0000313|Proteomes:UP000010556}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=23258410; DOI=10.1126/science.1230835;
RA   Zhang G., Cowled C., Shi Z., Huang Z., Bishop-Lilly K.A., Fang X.,
RA   Wynne J.W., Xiong Z., Baker M.L., Zhao W., Tachedjian M., Zhu Y., Zhou P.,
RA   Jiang X., Ng J., Yang L., Wu L., Xiao J., Feng Y., Chen Y., Sun X.,
RA   Zhang Y., Marsh G.A., Crameri G., Broder C.C., Frey K.G., Wang L.F.,
RA   Wang J.;
RT   "Comparative analysis of bat genomes provides insight into the evolution of
RT   flight and immunity.";
RL   Science 339:456-460(2013).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC   -!- SIMILARITY: Belongs to the methyltransferase superfamily.
CC       {ECO:0000256|ARBA:ARBA00008361}.
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DR   EMBL; KB103226; ELK34337.1; -; Genomic_DNA.
DR   RefSeq; XP_006758284.1; XM_006758221.2.
DR   RefSeq; XP_006758285.1; XM_006758222.2.
DR   RefSeq; XP_006758286.1; XM_006758223.2.
DR   AlphaFoldDB; L5M7M6; -.
DR   GeneID; 102755819; -.
DR   KEGG; myd:102755819; -.
DR   CTD; 25917; -.
DR   eggNOG; ENOG502QSE5; Eukaryota.
DR   OrthoDB; 1364859at2759; -.
DR   Proteomes; UP000010556; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   GO; GO:0009451; P:RNA modification; IEA:UniProt.
DR   GO; GO:0008033; P:tRNA processing; IEA:UniProtKB-KW.
DR   CDD; cd11715; THUMP_AdoMetMT; 1.
DR   Gene3D; 3.30.2130.30; -; 2.
DR   Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR   InterPro; IPR000241; RlmKL-like_Mtase.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   InterPro; IPR004114; THUMP_dom.
DR   PANTHER; PTHR14911; THUMP DOMAIN-CONTAINING; 1.
DR   PANTHER; PTHR14911:SF13; TRNA (GUANINE(6)-N2)-METHYLTRANSFERASE THUMP3; 1.
DR   Pfam; PF02926; THUMP; 1.
DR   Pfam; PF01170; UPF0020; 1.
DR   SMART; SM00981; THUMP; 1.
DR   SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR   SUPFAM; SSF143437; THUMP domain-like; 1.
DR   PROSITE; PS51165; THUMP; 1.
DR   PROSITE; PS01261; UPF0020; 1.
PE   3: Inferred from homology;
KW   Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW   Reference proteome {ECO:0000313|Proteomes:UP000010556};
KW   RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00529};
KW   Transferase {ECO:0000256|ARBA:ARBA00022603}.
FT   DOMAIN          169..285
FT                   /note="THUMP"
FT                   /evidence="ECO:0000259|PROSITE:PS51165"
FT   REGION          144..173
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        152..173
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   506 AA;  57198 MW;  086B8A6B748B6A27 CRC64;
     MSDVQEATNQ LLHVNLHENQ RYIHVTESVP RSESEHLRVT IGATVPTGFE QVAADEVREK
     LRSSCKISKD RGKIYFDISV ESLAQVHRLR SVDNLFVVVQ ELKDFQFKET KEKVLKDFEE
     LAGKLPWSDP LKVWKINTSF KKKKTKRKKL NQNLSKEKID NGGDKRDERD VKKELSNNAL
     DSHILDYYEK PAIKEEISTL VGDILASCKN ENDESSKEDT EPEVLKFRVT CNRAGEKHCF
     SSNEAARDFG GAVQDYFKWK ADMTNFDVEV LLNIHDNEVI VGIALTEESL HRRNITHFGP
     TTLRSTLAYG MLRLCAPQPS DVIVDPMCGT GAIPIEGATE WSNCFHIAGD NNPLAVNRAA
     NNISSLLTKS QIKEGKLSWG LPIDAIQWDI CNLPLRTGSV DIIVTDMPFG KRMGSKKRNW
     NLYPACLWEM SRICKPGTGR AALLTQDKKC FTKALSGMEH VWRKVHTVWV NIGGLHAAVY
     LLNRTPQAFV HPSGQDKEEL LRAKND
//