ID L5M907_MYODS Unreviewed; 352 AA.
AC L5M907;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2013, sequence version 1.
DT 24-JAN-2024, entry version 45.
DE SubName: Full=Inhibin beta C chain {ECO:0000313|EMBL:ELK35089.1};
GN ORFNames=MDA_GLEAN10006659 {ECO:0000313|EMBL:ELK35089.1};
OS Myotis davidii (David's myotis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC Myotis.
OX NCBI_TaxID=225400 {ECO:0000313|EMBL:ELK35089.1, ECO:0000313|Proteomes:UP000010556};
RN [1] {ECO:0000313|Proteomes:UP000010556}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23258410; DOI=10.1126/science.1230835;
RA Zhang G., Cowled C., Shi Z., Huang Z., Bishop-Lilly K.A., Fang X.,
RA Wynne J.W., Xiong Z., Baker M.L., Zhao W., Tachedjian M., Zhu Y., Zhou P.,
RA Jiang X., Ng J., Yang L., Wu L., Xiao J., Feng Y., Chen Y., Sun X.,
RA Zhang Y., Marsh G.A., Crameri G., Broder C.C., Frey K.G., Wang L.F.,
RA Wang J.;
RT "Comparative analysis of bat genomes provides insight into the evolution of
RT flight and immunity.";
RL Science 339:456-460(2013).
CC -!- FUNCTION: Inhibins and activins inhibit and activate, respectively, the
CC secretion of follitropin by the pituitary gland. Inhibins/activins are
CC involved in regulating a number of diverse functions such as
CC hypothalamic and pituitary hormone secretion, gonadal hormone
CC secretion, germ cell development and maturation, erythroid
CC differentiation, insulin secretion, nerve cell survival, embryonic
CC axial development or bone growth, depending on their subunit
CC composition. Inhibins appear to oppose the functions of activins.
CC {ECO:0000256|ARBA:ARBA00002588}.
CC -!- SUBUNIT: Homodimeric or heterodimeric through association with alpha
CC and beta subunits, linked by one or more disulfide bonds. Inhibins are
CC heterodimers of one alpha and one beta subunit. Activins are homo- or
CC heterodimers of beta subunits only. {ECO:0000256|ARBA:ARBA00026046}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the TGF-beta family.
CC {ECO:0000256|ARBA:ARBA00006656, ECO:0000256|RuleBase:RU000354}.
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DR EMBL; KB102780; ELK35089.1; -; Genomic_DNA.
DR RefSeq; XP_006757398.1; XM_006757335.2.
DR AlphaFoldDB; L5M907; -.
DR GeneID; 102765085; -.
DR KEGG; myd:102765085; -.
DR CTD; 3626; -.
DR eggNOG; KOG3900; Eukaryota.
DR OrthoDB; 3015718at2759; -.
DR Proteomes; UP000010556; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR GO; GO:0005179; F:hormone activity; IEA:InterPro.
DR CDD; cd19406; TGF_beta_INHBC_E; 1.
DR Gene3D; 2.60.120.970; -; 1.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR001318; Inhibin_betaC.
DR InterPro; IPR001839; TGF-b_C.
DR InterPro; IPR015615; TGF-beta-rel.
DR InterPro; IPR017948; TGFb_CS.
DR PANTHER; PTHR11848:SF130; INHIBIN BETA C CHAIN; 1.
DR PANTHER; PTHR11848; TGF-BETA FAMILY; 1.
DR Pfam; PF00019; TGF_beta; 1.
DR PRINTS; PR00672; INHIBINBC.
DR SMART; SM00204; TGFB; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS00250; TGF_BETA_1; 1.
DR PROSITE; PS51362; TGF_BETA_2; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Growth factor {ECO:0000256|ARBA:ARBA00023030,
KW ECO:0000256|RuleBase:RU000354};
KW Reference proteome {ECO:0000313|Proteomes:UP000010556};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..352
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003971041"
FT DOMAIN 232..352
FT /note="TGF-beta family profile"
FT /evidence="ECO:0000259|PROSITE:PS51362"
SQ SEQUENCE 352 AA; 38620 MW; 4C573E170AA39D26 CRC64;
MISSLFLAFL FLALATVATT RADHQCLACG EHALDLQSQR ELLLPLAKRS ILDKLHLNQR
PTLSRPVSRA ALRIALQRLH GRPQGALPEA DRGQEYEIIS FAETGFSNIN QTRLDFHFFS
DRTAGGMEVQ EASLRFFVQL PPNTTWTLKV RVLVLGSHEA NLTLATQHLL TVDASGWHQL
LLGPEAQAAC SQGHLTLELV PEGQVAESSV ILSGAAQRPF VAARVRVGSK HRIRRHGINC
QSGSKMCCRQ EFFVDFREIG WHDWIIQPEG YSMNFCTGQC PLHVAGMPGI AASFHTTVLN
LLKANAATGT PGGGSCCVPT VRRPLSLLYY DRDSNIVKTD IPDMVVEACG CS
//
