ID L5MAC0_MYODS Unreviewed; 616 AA.
AC L5MAC0;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2013, sequence version 1.
DT 22-FEB-2023, entry version 43.
DE SubName: Full=Rho GTPase-activating protein 22 {ECO:0000313|EMBL:ELK35225.1};
GN ORFNames=MDA_GLEAN10013124 {ECO:0000313|EMBL:ELK35225.1};
OS Myotis davidii (David's myotis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC Myotis.
OX NCBI_TaxID=225400 {ECO:0000313|EMBL:ELK35225.1, ECO:0000313|Proteomes:UP000010556};
RN [1] {ECO:0000313|Proteomes:UP000010556}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23258410; DOI=10.1126/science.1230835;
RA Zhang G., Cowled C., Shi Z., Huang Z., Bishop-Lilly K.A., Fang X.,
RA Wynne J.W., Xiong Z., Baker M.L., Zhao W., Tachedjian M., Zhu Y., Zhou P.,
RA Jiang X., Ng J., Yang L., Wu L., Xiao J., Feng Y., Chen Y., Sun X.,
RA Zhang Y., Marsh G.A., Crameri G., Broder C.C., Frey K.G., Wang L.F.,
RA Wang J.;
RT "Comparative analysis of bat genomes provides insight into the evolution of
RT flight and immunity.";
RL Science 339:456-460(2013).
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DR EMBL; KB102490; ELK35225.1; -; Genomic_DNA.
DR Proteomes; UP000010556; Unassembled WGS sequence.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd04390; RhoGAP_ARHGAP22_24_25; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR PANTHER; PTHR15228:SF22; RHO GTPASE-ACTIVATING PROTEIN 22; 1.
DR PANTHER; PTHR15228; SPERMATHECAL PHYSIOLOGY VARIANT; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000010556};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..34
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 35..616
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003971030"
FT DOMAIN 83..105
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 115..309
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 311..519
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 541..603
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 371..385
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 403..418
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 425..484
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 616 AA; 67349 MW; AB7480BAEC73B139 CRC64;
MELESAFLVA GSPCDFRRLL AFLCLSLSLS KGLAVPGDRS SYLSLTTSRT MPFCPARHLK
RSRRLPRGGA GEREKVPASP EGLLLMASSQ RDMEDWVQAI RRVIWAPFGG GIFGQRLEDT
VHHERKYGPR LAPLLVEQCV DFIRARGLSE EGLFRLPGQA NLVRDLQDAF DCGEKPLFDS
TTDVHTVASL LKLYLRELPE PVVPFARYED FLSCAQLLTK DEGEGTLELA EQVSSLPLAN
YNLLSYICKF LDEVQSHSNV NKMSVQNLAT VFGPNILRPQ IEDPVTIMEG TSLVQHLMTV
LIRRHSQLFS GRVPEGPAAP HGGPPCTDLV SGRGGRGHAL QERSPRPWEE AXXXXXXXXX
XXXXXXXXSS PEVPTVSSGG NWLMNGLSSL RGRRRASSGD RLKDSASQRL STYDNVPAPS
PGPSAPSVSS SAWSGASSCE ASPGGSVSSC TACRASDSAC SSLHPEGTPE PSSVPSSSEE
LRSPNPGRSL EEAAVRLSSS EPSEPGSPAR DPTPHSTALQ GLVAELRAEL CRQRTEHELS
VRRLEDGTAD LRKRMLRLEE ELDQEKKKYT MLQIRLRNSE RARADAERRN QLLQEEMEEF
FSTLGSLTVG ARGAPQ
//
