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Database: UniProt
Entry: L5MAP5_MYODS
LinkDB: L5MAP5_MYODS
Original site: L5MAP5_MYODS 
ID   L5MAP5_MYODS            Unreviewed;      1777 AA.
AC   L5MAP5;
DT   06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT   06-MAR-2013, sequence version 1.
DT   10-MAY-2017, entry version 29.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
GN   ORFNames=MDA_GLEAN10015510 {ECO:0000313|EMBL:ELK35350.1};
OS   Myotis davidii (David's myotis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Chiroptera; Microchiroptera;
OC   Vespertilionidae; Myotis.
OX   NCBI_TaxID=225400 {ECO:0000313|EMBL:ELK35350.1, ECO:0000313|Proteomes:UP000010556};
RN   [1] {ECO:0000313|Proteomes:UP000010556}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=23258410; DOI=10.1126/science.1230835;
RA   Zhang G., Cowled C., Shi Z., Huang Z., Bishop-Lilly K.A., Fang X.,
RA   Wynne J.W., Xiong Z., Baker M.L., Zhao W., Tachedjian M., Zhu Y.,
RA   Zhou P., Jiang X., Ng J., Yang L., Wu L., Xiao J., Feng Y., Chen Y.,
RA   Sun X., Zhang Y., Marsh G.A., Crameri G., Broder C.C., Frey K.G.,
RA   Wang L.F., Wang J.;
RT   "Comparative analysis of bat genomes provides insight into the
RT   evolution of flight and immunity.";
RL   Science 339:456-460(2013).
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|RuleBase:RU361132}.
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DR   EMBL; KB102468; ELK35350.1; -; Genomic_DNA.
DR   Proteomes; UP000010556; Unassembled WGS sequence.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR   InterPro; IPR008054; Na_channel_a8su.
DR   InterPro; IPR001696; Na_channel_asu.
DR   InterPro; IPR010526; Na_trans_assoc.
DR   InterPro; IPR024583; Na_trans_cytopl.
DR   Pfam; PF00520; Ion_trans; 4.
DR   Pfam; PF00612; IQ; 1.
DR   Pfam; PF06512; Na_trans_assoc; 1.
DR   Pfam; PF11933; Na_trans_cytopl; 1.
DR   PRINTS; PR00170; NACHANNEL.
DR   PRINTS; PR01667; NACHANNEL8.
DR   SMART; SM00015; IQ; 1.
DR   PROSITE; PS50096; IQ; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000010556};
KW   Ion channel {ECO:0000256|RuleBase:RU361132,
KW   ECO:0000313|EMBL:ELK35350.1};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132};
KW   Reference proteome {ECO:0000313|Proteomes:UP000010556};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM     66     85       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM     97    118       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    124    144       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    218    237       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    257    284       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    564    588       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    600    621       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    671    690       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    749    775       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    997   1015       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1036   1055       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1067   1090       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1111   1139       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1236   1262       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1320   1338       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1350   1368       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1380   1400       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1437   1465       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1540   1563       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   DOMAIN       23    291       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      359    405       Na_trans_cytopl. {ECO:0000259|Pfam:
FT                                PF11933}.
FT   DOMAIN      570    779       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      789    990       Na_trans_assoc. {ECO:0000259|Pfam:
FT                                PF06512}.
FT   DOMAIN      995   1270       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1319   1573       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   COILED      281    329       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1777 AA;  202680 MW;  03F991186D407E71 CRC64;
     MSQQVSQVRQ IQHTLAIALP PKSSSALWRT WGYTFTGIYT FESLVKIIAR GFCIDGFTFL
     RDPWNWLDFS VIMMAYITEF VNLGNVSALR TFRVLRALKT ISVIPGLKTI VGALIQSVKK
     LSDVMILTVF CLSVFALIGL QLFMGNLRNK CVVWPINFND SYLENGTRGF DWDEYINNKT
     NFYTVPGMLE PLLCGNSSDA GQCPEGYQCM KAGRNPNYGY TSFDTFSWAF LALFRLMTQD
     YWENLYQLTL RAAGKTYMIF FVLVIFVGSF YLVNLILAVV AMAYEEQNQA TLEEAEQKEA
     EFKAMLEQLK KQQEEAQVSE DAIEEEGEEE GGSPRSSSEM SKLSSKSAKE RRNRRRKRKQ
     KELSEGEEKG DPEKVFKSES EDGMRRKGIR LPDNRIGRKF SIMNQGTTEV EIKKKGPGSL
     LVSMEQLASY GRKDRINSIL SVVTNTLVED ALKPLFSSTV PPTEQLLLNC SMPAVMLLSV
     PDLSIRNLMV CQCHHLGGIM RPSLKTIPSS PEVETCSTLS ENVQEQELEE SQRKCPPCWY
     KFANTFLIWE CHPYWIKLKE IVNLIVMDPF VDLAITICIV LNTLFMAMEH HPMTPQFEHV
     LSVGNLVFTG IFTAEMFLKL IAMDPYYYFQ EGWNIFDGFI VSLSLMELSL ADVEGLSVLR
     SFRLIIGNSV GALGNLTLVL AIIVFIFAVV GMQLFGKSYK ECVCKINQDC ELPRWHMHDF
     FHSFLIVFRV LCGEWIETMW DCMEVAGQAM CLIVFMMVMV IGNLVVLNLF LALLLSSFSA
     DNLAATDDDG EMNNLQISVI RIKKGVAWTK VKVHAFMQAH FKQREADEVK PLDEMYDKKA
     NCIANHTGAD IHRNGDFQKN GNGTTSGIGS SVEKYIIDED HMSFINNPNL TVRVPIAVGE
     SDFENVNTED VSSESDPDGS KDKLDDTSSS EGSTIDIKPE VEEVPVEQPE EYLDPEACFT
     EGCVRRFKCC TVNIEEGLGK SWWILRKTCF LIVEHNWFET FIIFMILLSS GALAFEDIYI
     EQRRTIRTVL EYADKVFTYI FILEMLLKWT AYGFVKFFTN AWCWLDFLIV AVSLVSLVAN
     ALGYSELGAI KSLRTLRALR PLRALSRFEG MRVVVNALVG AIPSIMNVLL VCLIFWLIFS
     IMGVNLFAGK YHYCFNETSE ERFEIEIVNN KTDCEKLMEG NNTEIRWKNV KINFDNVGAG
     YLALLQVATF KGWMDIMYAA VDSRKPEEQP KYEDNIYMYI YFVIFIIFGS FFTLNLFIGV
     IIDNFNQQKK KIGQDIFMTE EQKKYYNAMK KLGSKKPQKP IPRPLNKIQG IVFDFVTQQA
     FDIVIMMLIC LNMVTMMVET DTQSKQMENI LYWINLVFVI FFTCECVLKM FALRHYYFTI
     GWNIFDFVVV ILSIVGMFLA DIIEKYFVSP TLFRVIRLAR IGRILRLIKG AKGIRTLLFA
     LMMSLPALFN IGLLLFLVMF IFSIFGMSNF AYVKHEAGID DMFNFETFGN SMICLFQITT
     SAGWDGLLLP ILNRPPDCSL DKEHPGSGFK GDCGNPSVGI FFFVSYIIIS FLIVVNMYIA
     IILENFSVAT EESADPLSED DFETFYEIWE KFDPDATQFI EYCKLADFAD ALEHPLRVPK
     PNTIELIAMD LPMVSGDRIH CLDILFAFTK RVLGDSGELD ILRQQMEERF VASNPSKVSY
     EPITTTLRRK QEEVSAVVLQ RAYRGHLARR GFICKKTASN KLENGGTHPE KKESTPSTAS
     LPSYDSVTKP EKEKQQRAEE GRRERAKRQK EVRESKC
//
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