ID L7E0Q1_MICAE Unreviewed; 592 AA.
AC L7E0Q1;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2013, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=Subtilase family protein {ECO:0000313|EMBL:ELP52461.1};
DE EC=3.4.21.66 {ECO:0000313|EMBL:ELP52461.1};
GN ORFNames=O53_5356 {ECO:0000313|EMBL:ELP52461.1};
OS Microcystis aeruginosa TAIHU98.
OC Bacteria; Cyanobacteriota; Cyanophyceae; Oscillatoriophycideae;
OC Chroococcales; Microcystaceae; Microcystis.
OX NCBI_TaxID=1134457 {ECO:0000313|EMBL:ELP52461.1, ECO:0000313|Proteomes:UP000010932};
RN [1] {ECO:0000313|EMBL:ELP52461.1, ECO:0000313|Proteomes:UP000010932}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TAIHU98 {ECO:0000313|EMBL:ELP52461.1,
RC ECO:0000313|Proteomes:UP000010932};
RX PubMed=23766403;
RA Yang C., Zhang W., Ren M., Song L., Li T., Zhao J.;
RT "Whole-Genome Sequence of Microcystis aeruginosa TAIHU98, a Nontoxic Bloom-
RT Forming Strain Isolated from Taihu Lake, China.";
RL Genome Announc. 1:e00333-13(2013).
CC -!- SIMILARITY: Belongs to the peptidase S8 family.
CC {ECO:0000256|ARBA:ARBA00011073, ECO:0000256|PROSITE-ProRule:PRU01240}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ELP52461.1}.
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DR EMBL; ANKQ01000004; ELP52461.1; -; Genomic_DNA.
DR RefSeq; WP_002740233.1; NZ_ANKQ01000004.1.
DR AlphaFoldDB; L7E0Q1; -.
DR PATRIC; fig|1134457.3.peg.5176; -.
DR Proteomes; UP000010932; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd07484; Peptidases_S8_Thermitase_like; 1.
DR Gene3D; 3.40.50.200; Peptidase S8/S53 domain; 1.
DR InterPro; IPR045986; DUF5942.
DR InterPro; IPR017295; Pept_S8A_subtilisin_cyanobac-1.
DR InterPro; IPR000209; Peptidase_S8/S53_dom.
DR InterPro; IPR036852; Peptidase_S8/S53_dom_sf.
DR InterPro; IPR023828; Peptidase_S8_Ser-AS.
DR InterPro; IPR015500; Peptidase_S8_subtilisin-rel.
DR InterPro; IPR034084; Thermitase-like_dom.
DR PANTHER; PTHR43806:SF59; CEREVISIN-RELATED; 1.
DR PANTHER; PTHR43806; PEPTIDASE S8; 1.
DR Pfam; PF19366; DUF5942; 1.
DR Pfam; PF00082; Peptidase_S8; 1.
DR PIRSF; PIRSF037851; Subtilisin_cyano; 1.
DR PRINTS; PR00723; SUBTILISIN.
DR SUPFAM; SSF52743; Subtilisin-like; 1.
DR PROSITE; PS51892; SUBTILASE; 1.
DR PROSITE; PS00138; SUBTILASE_SER; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU01240}; Membrane {ECO:0000256|SAM:Phobius};
KW Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|PROSITE-
KW ProRule:PRU01240};
KW Serine protease {ECO:0000256|ARBA:ARBA00022825, ECO:0000256|PROSITE-
KW ProRule:PRU01240}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 422..447
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 459..480
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 500..525
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 532..551
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 563..583
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 135..387
FT /note="Peptidase S8/S53"
FT /evidence="ECO:0000259|Pfam:PF00082"
FT DOMAIN 400..588
FT /note="DUF5942"
FT /evidence="ECO:0000259|Pfam:PF19366"
FT ACT_SITE 144
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01240"
FT ACT_SITE 177
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01240"
FT ACT_SITE 341
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01240"
SQ SEQUENCE 592 AA; 63413 MW; BCFB4D0834CFB502 CRC64;
MKKILLLTLF VIGLGFALFH FTGLANRGEY QSILIDFKDD IPVNVLDEQL NTVNKKAGKT
TSLNSIFSID EHLYIIDGDS KLLKTLRNSE LKKYTESIEP DYIYHAFIAP NDPDYSKQWN
LRGINIERAW EENHGEGITV AVIDTGVSKV PDLRETEFVE GYDFVNDRSN AEDDNGHGTH
VAGTIAQSTN NNYGVAGIAY KAKIMPLKVL SGTGGGTVGD IAEAIRFAVD NKADVINMSL
GGGGETQVMK EAIEYAYSKG VVIVAAAGNA DDNSAAYPAR FPHVIGVSAV DASGNKAPYS
NFGAGIDIAA PGGSDTGKII QETIDPAKGG EPAFLGFQGT SMAAPHVAGV VALIKAAGIK
EPNAVLEVLQ QSARKINDDP FNHFGAGQLD AGSAVQLALK GQITFQDFWR WLRDNGYLNP
RFWIDGGAVA VLPKMAMVLG SYLLAWWLRN YFPFPWNGFL NAGLIFGSSG LFFLRGLYIF
DLPQWPFRVM GSSLSDLGGV IQGSSALNPL FASVILPFVL IALLLGHPQA KWLAVGVSLA
MAVSLGISAV IDPTLVWLGS GRIAQAFLGI NALLCLGLGY LALKSATSSR YA
//
