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Database: UniProt
Entry: L7EXM2_9ACTN
LinkDB: L7EXM2_9ACTN
Original site: L7EXM2_9ACTN 
ID   L7EXM2_9ACTN            Unreviewed;       623 AA.
AC   L7EXM2;
DT   06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT   06-MAR-2013, sequence version 1.
DT   25-OCT-2017, entry version 36.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377,
GN   ECO:0000313|EMBL:ELP63817.1};
GN   ORFNames=STRTUCAR8_05617 {ECO:0000313|EMBL:ELP63817.1};
OS   Streptomyces turgidiscabies Car8.
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces.
OX   NCBI_TaxID=698760 {ECO:0000313|EMBL:ELP63817.1, ECO:0000313|Proteomes:UP000010931};
RN   [1] {ECO:0000313|EMBL:ELP63817.1, ECO:0000313|Proteomes:UP000010931}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Car8 {ECO:0000313|EMBL:ELP63817.1,
RC   ECO:0000313|Proteomes:UP000010931};
RX   PubMed=21087627; DOI=10.1016/j.plasmid.2010.11.002;
RA   Huguet-Tapia J.C., Badger J.H., Loria R., Pettis G.S.;
RT   "Streptomyces turgidiscabies Car8 contains a modular pathogenicity
RT   island that shares virulence genes with other actinobacterial plant
RT   pathogens.";
RL   Plasmid 65:118-124(2011).
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00735475}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00911680}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:ELP63817.1}.
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DR   EMBL; AEJB01000501; ELP63817.1; -; Genomic_DNA.
DR   RefSeq; WP_006381192.1; NZ_AEJB01000501.1.
DR   EnsemblBacteria; ELP63817; ELP63817; STRTUCAR8_05617.
DR   PATRIC; fig|698760.3.peg.7293; -.
DR   OrthoDB; POG091H02FF; -.
DR   Proteomes; UP000010931; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00747950};
KW   Complete proteome {ECO:0000313|Proteomes:UP000010931};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00911664};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00747996};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00911684};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00747895};
KW   Reference proteome {ECO:0000313|Proteomes:UP000010931}.
FT   DOMAIN      316    444       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      530    599       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     324    331       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   623 AA;  69121 MW;  FB7BADCEE4E2102D CRC64;
     MADVPADLAA VWPRVLEHLL GEGRGQGVEV KDERWIRRCE PLALVADTAL LAVPNEFAKG
     VLEGRLAPIV SETLSRECGR PIRIAITVDE SVGEPSPPAP APPQSRYEAP ELPPSRDPYQ
     GYGRHRADDH SQTRDGQQPS HADQLPTARP AYPSEYQRPE PGAWPRPTQD DYGWQQPRLG
     FPERDPYASP SSDYRPQPPR DRSPYEQQRS EYEQQRSDYG QQRSDYEQRD GRRDLSDSQS
     GGGHAHRGGP GGPGGAVRPG GGAPGSPASR QAPAPGPGEP TARLNPKYLF DTFVIGASNR
     FAHAAAVAVA EAPAKAYNPL FIYGESGLGK THLLHAIGHY ARSLYPGTRV RYVSSEEFTN
     EFINSIRDGK GDSFRKRYRE MDILLVDDIQ FLADKESTQE EFFHTFNTLH NANKQIVLSS
     DRPPKQLVTL EDRLRNRFEW GLITDVQPPE LETRIAILRK KAVQEQLNAP PEVLEFIASR
     ISRNIRELEG ALIRVTAFAS LNRQPVDLGL TEIVLKDLIP GGEDSTPEIT APAIMGATAD
     YFGITVEDLC GSSRGRQLVT ARQIAMYVCR ELTDLSLPKI GAQFGGRDHT TVMHADRKIR
     ALMAERRSIY NQVTELTNRI KNG
//
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