ID L7F0W3_9ACTN Unreviewed; 351 AA.
AC L7F0W3;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2013, sequence version 1.
DT 24-JAN-2024, entry version 40.
DE SubName: Full=Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex family protein {ECO:0000313|EMBL:ELP64225.1};
DE Flags: Fragment;
GN ORFNames=STRTUCAR8_03070 {ECO:0000313|EMBL:ELP64225.1};
OS Streptomyces turgidiscabies Car8.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=698760 {ECO:0000313|EMBL:ELP64225.1, ECO:0000313|Proteomes:UP000010931};
RN [1] {ECO:0000313|EMBL:ELP64225.1, ECO:0000313|Proteomes:UP000010931}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Car8 {ECO:0000313|EMBL:ELP64225.1,
RC ECO:0000313|Proteomes:UP000010931};
RX PubMed=21087627; DOI=10.1016/j.plasmid.2010.11.002;
RA Huguet-Tapia J.C., Badger J.H., Loria R., Pettis G.S.;
RT "Streptomyces turgidiscabies Car8 contains a modular pathogenicity island
RT that shares virulence genes with other actinobacterial plant pathogens.";
RL Plasmid 65:118-124(2011).
CC -!- COFACTOR:
CC Name=(R)-lipoate; Xref=ChEBI:CHEBI:83088;
CC Evidence={ECO:0000256|ARBA:ARBA00001938};
CC -!- SIMILARITY: Belongs to the 2-oxoacid dehydrogenase family.
CC {ECO:0000256|ARBA:ARBA00007317}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ELP64225.1}.
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DR EMBL; AEJB01000466; ELP64225.1; -; Genomic_DNA.
DR RefSeq; WP_006380764.1; NZ_AEJB01000466.1.
DR AlphaFoldDB; L7F0W3; -.
DR STRING; 85558.T45_08827; -.
DR PATRIC; fig|698760.3.peg.6900; -.
DR Proteomes; UP000010931; Unassembled WGS sequence.
DR GO; GO:0016746; F:acyltransferase activity; IEA:InterPro.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 1.
DR Gene3D; 4.10.320.10; E3-binding domain; 1.
DR InterPro; IPR001078; 2-oxoacid_DH_actylTfrase.
DR InterPro; IPR014276; 2-oxoglutarate_DH_E2.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR036625; E3-bd_dom_sf.
DR InterPro; IPR004167; PSBD.
DR NCBIfam; TIGR02927; SucB_Actino; 1.
DR PANTHER; PTHR43178; DIHYDROLIPOAMIDE ACETYLTRANSFERASE COMPONENT OF PYRUVATE DEHYDROGENASE COMPLEX; 1.
DR PANTHER; PTHR43178:SF5; LIPOAMIDE ACYLTRANSFERASE COMPONENT OF BRANCHED-CHAIN ALPHA-KETO ACID DEHYDROGENASE COMPLEX, MITOCHONDRIAL; 1.
DR Pfam; PF00198; 2-oxoacid_dh; 1.
DR Pfam; PF02817; E3_binding; 1.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 1.
DR SUPFAM; SSF47005; Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex; 1.
DR PROSITE; PS51826; PSBD; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000010931};
KW Transferase {ECO:0000313|EMBL:ELP64225.1}.
FT DOMAIN 46..83
FT /note="Peripheral subunit-binding (PSBD)"
FT /evidence="ECO:0000259|PROSITE:PS51826"
FT REGION 1..31
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 94..113
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ELP64225.1"
SQ SEQUENCE 351 AA; 35830 MW; C7A9348079A05C07 CRC64;
APAAPAPAPA PVQAAAPVAP PAPAPAPVAP AAPAPAAAQA TDEGAYVTPL VRKLAAENGV
DLGSVKGTGV GGRIRKQDVL AAAEAAKAAA AAPAPAAAAP AAKKAPTLEA SPLRGQTIKM
PRIRKVIGDN MVKALHEQAQ LSSVVEVDIT RLMKLRAQAK DSFAAREGVK LSPMPFFVKA
AAQALKAHPA VNARINVEEG TITYFDTESV GIAVDSEKGL MTPVIKHAGD LNIAGIAKAT
AELAGKVRAN KITPDELSGA TFTISNTGSR GALFDTIIVP PNQVAILGIG ATVKRPAVIE
TEEGTVIGVR DMTYLTLSYD HRLVDGADAA RYLTAVKAIL EAGEFEVELG L
//
