ID   L7FKH1_ENTIV            Unreviewed;       416 AA.
AC   L7FKH1;
DT   06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT   06-MAR-2013, sequence version 1.
DT   27-MAR-2024, entry version 29.
DE   RecName: Full=Rho-GAP domain-containing protein {ECO:0000259|PROSITE:PS50238};
GN   ORFNames=EIN_284930 {ECO:0000313|EMBL:ELP84907.1};
OS   Entamoeba invadens IP1.
OC   Eukaryota; Amoebozoa; Evosea; Archamoebae; Mastigamoebida; Entamoebidae;
OC   Entamoeba.
OX   NCBI_TaxID=370355 {ECO:0000313|EMBL:ELP84907.1, ECO:0000313|Proteomes:UP000014680};
RN   [1] {ECO:0000313|EMBL:ELP84907.1, ECO:0000313|Proteomes:UP000014680}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=IP1 {ECO:0000313|EMBL:ELP84907.1,
RC   ECO:0000313|Proteomes:UP000014680};
RA   Zafar N., Inman J., Hall N., Lorenzi H., Caler E.;
RL   Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Rho GTPase-activating protein involved in the signal
CC       transduction pathway. {ECO:0000256|ARBA:ARBA00037092}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; KB207106; ELP84907.1; -; Genomic_DNA.
DR   RefSeq; XP_004184253.1; XM_004184205.1.
DR   AlphaFoldDB; L7FKH1; -.
DR   EnsemblProtists; ELP84907; ELP84907; EIN_284930.
DR   GeneID; 14883891; -.
DR   KEGG; eiv:EIN_284930; -.
DR   VEuPathDB; AmoebaDB:EIN_284930; -.
DR   OrthoDB; 25758at2759; -.
DR   Proteomes; UP000014680; Unassembled WGS sequence.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   CDD; cd00159; RhoGAP; 1.
DR   Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR   InterPro; IPR008936; Rho_GTPase_activation_prot.
DR   InterPro; IPR000198; RhoGAP_dom.
DR   PANTHER; PTHR23176:SF129; RHO GTPASE ACTIVATING PROTEIN AT 16F, ISOFORM E-RELATED; 1.
DR   PANTHER; PTHR23176; RHO/RAC/CDC GTPASE-ACTIVATING PROTEIN; 1.
DR   Pfam; PF00620; RhoGAP; 1.
DR   SMART; SM00324; RhoGAP; 1.
DR   SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR   PROSITE; PS50238; RHOGAP; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000014680}.
FT   DOMAIN          101..281
FT                   /note="Rho-GAP"
FT                   /evidence="ECO:0000259|PROSITE:PS50238"
SQ   SEQUENCE   416 AA;  48172 MW;  CDF504D5D422683A CRC64;
     MNDPITIPLW DGKQIVEKVV TYYIHNDKHI LQIGHKTPII LESTLMRLNP KDKGLSPEQI
     PLSFCLIYDD TKTFVFQSKT VYRSWVNKIS VSTLNIGVFG FPLSVGIKKS GWYIPNPIYR
     SVQYLRKNDG VNTQGIFRMT AGMEQLEKLR AIVDDDEDLR FESRDDDCIV AASFLKYYLR
     TLPDSVIPSR YLLDFINLPK QRMINNKFIM SLPEENQNVL WYIFSFLDEV VQKKHINKMN
     EYNMATCICL VLCSCPEQDV LVTGKLIESV MYLLNHFNEM FADVALRNCD KMSEPEMPAF
     FNPHIDVADF KNSVKSELKK RNHRRSLTST LPLNPNTFEG RHTPQTPKSV EYKCVLKTLT
     PRGSSEFKTH RLNITQTNPQ LLSKNQPFIM SSETRSVIVG TPRFKNEVCL RYDVEN
//