ID L7JUZ6_TRAHO Unreviewed; 300 AA.
AC L7JUZ6;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2013, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE RecName: Full=Serine/threonine-protein phosphatase {ECO:0000256|RuleBase:RU004273};
DE EC=3.1.3.16 {ECO:0000256|RuleBase:RU004273};
GN ORFNames=THOM_1795 {ECO:0000313|EMBL:ELQ75298.1};
OS Trachipleistophora hominis (Microsporidian parasite).
OC Eukaryota; Fungi; Fungi incertae sedis; Microsporidia; Pleistophoridae;
OC Trachipleistophora.
OX NCBI_TaxID=72359 {ECO:0000313|EMBL:ELQ75298.1, ECO:0000313|Proteomes:UP000011185};
RN [1] {ECO:0000313|EMBL:ELQ75298.1, ECO:0000313|Proteomes:UP000011185}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23133373; DOI=10.1371/journal.ppat.1002979;
RA Heinz E., Williams T.A., Nakjang S., Noel C.J., Swan D.C., Goldberg A.V.,
RA Harris S.R., Weinmaier T., Markert S., Becher D., Bernhardt J., Dagan T.,
RA Hacker C., Lucocq J.M., Schweder T., Rattei T., Hall N., Hirt R.P.,
RA Embley T.M.;
RT "The genome of the obligate intracellular parasite Trachipleistophora
RT hominis: new insights into microsporidian genome dynamics and reductive
RT evolution.";
RL PLoS Pathog. 8:E1002979-E1002979(2012).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] +
CC phosphate; Xref=Rhea:RHEA:47004, Rhea:RHEA-COMP:11060, Rhea:RHEA-
CC COMP:11605, ChEBI:CHEBI:15377, ChEBI:CHEBI:30013, ChEBI:CHEBI:43474,
CC ChEBI:CHEBI:61977; EC=3.1.3.16;
CC Evidence={ECO:0000256|RuleBase:RU004273};
CC -!- SIMILARITY: Belongs to the PPP phosphatase family.
CC {ECO:0000256|RuleBase:RU004273}.
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DR EMBL; JH993974; ELQ75298.1; -; Genomic_DNA.
DR AlphaFoldDB; L7JUZ6; -.
DR STRING; 72359.L7JUZ6; -.
DR VEuPathDB; MicrosporidiaDB:THOM_1795; -.
DR HOGENOM; CLU_004962_8_1_1; -.
DR InParanoid; L7JUZ6; -.
DR OMA; HQLCMDG; -.
DR Proteomes; UP000011185; Unassembled WGS sequence.
DR GO; GO:0017018; F:myosin phosphatase activity; IEA:UniProtKB-EC.
DR Gene3D; 3.60.21.10; -; 1.
DR InterPro; IPR004843; Calcineurin-like_PHP_ApaH.
DR InterPro; IPR029052; Metallo-depent_PP-like.
DR InterPro; IPR047129; PPA2-like.
DR InterPro; IPR006186; Ser/Thr-sp_prot-phosphatase.
DR PANTHER; PTHR45619; SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A-RELATED; 1.
DR PANTHER; PTHR45619:SF6; SERINE_THREONINE-PROTEIN PHOSPHATASE PP2A-LIKE PPG1; 1.
DR Pfam; PF00149; Metallophos; 1.
DR PRINTS; PR00114; STPHPHTASE.
DR SMART; SM00156; PP2Ac; 1.
DR SUPFAM; SSF56300; Metallo-dependent phosphatases; 1.
DR PROSITE; PS00125; SER_THR_PHOSPHATASE; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|RuleBase:RU004273, ECO:0000313|EMBL:ELQ75298.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000011185}.
FT DOMAIN 105..110
FT /note="Serine/threonine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS00125"
SQ SEQUENCE 300 AA; 33944 MW; E4BD08C03D1CF82A CRC64;
MDVLESKVLN GQILSAQEID HLCTKVISIL VNEPNILSKS SPITIVGDIH GQFFDLLNIF
KKFGSPKCTR YVFLGDYVDR GVHSVETLSL LLIYKVMYPE NMTILRGNHE SSKISSIYGF
SDEVRKKYGD LAAYRAFCEV FEYLVLGCIV DGRLFCVHGG ISSSIINLDD FTKMPRFYHA
PEKSKIGDLL WSDPSQQLGF TPNVRGTGCA YGNDVVTKFL MVNQLQKIIR SHQLVMEGYK
FNFKDESVAT VWSAPNYCYR CGNIASVLMV DGEVRKENFR LFVAVDDQAP GYDLRSLFFR
//
