ID L7JXG6_TRAHO Unreviewed; 687 AA.
AC L7JXG6;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2013, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE SubName: Full=Xaa-Pro aminopeptidase {ECO:0000313|EMBL:ELQ76124.1};
DE EC=3.4.11.9 {ECO:0000313|EMBL:ELQ76124.1};
GN ORFNames=THOM_0905 {ECO:0000313|EMBL:ELQ76124.1};
OS Trachipleistophora hominis (Microsporidian parasite).
OC Eukaryota; Fungi; Fungi incertae sedis; Microsporidia; Pleistophoridae;
OC Trachipleistophora.
OX NCBI_TaxID=72359 {ECO:0000313|EMBL:ELQ76124.1, ECO:0000313|Proteomes:UP000011185};
RN [1] {ECO:0000313|EMBL:ELQ76124.1, ECO:0000313|Proteomes:UP000011185}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23133373; DOI=10.1371/journal.ppat.1002979;
RA Heinz E., Williams T.A., Nakjang S., Noel C.J., Swan D.C., Goldberg A.V.,
RA Harris S.R., Weinmaier T., Markert S., Becher D., Bernhardt J., Dagan T.,
RA Hacker C., Lucocq J.M., Schweder T., Rattei T., Hall N., Hirt R.P.,
RA Embley T.M.;
RT "The genome of the obligate intracellular parasite Trachipleistophora
RT hominis: new insights into microsporidian genome dynamics and reductive
RT evolution.";
RL PLoS Pathog. 8:E1002979-E1002979(2012).
CC -!- SIMILARITY: Belongs to the peptidase M24B family.
CC {ECO:0000256|ARBA:ARBA00008766}.
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DR EMBL; JH993872; ELQ76124.1; -; Genomic_DNA.
DR AlphaFoldDB; L7JXG6; -.
DR STRING; 72359.L7JXG6; -.
DR VEuPathDB; MicrosporidiaDB:THOM_0905; -.
DR HOGENOM; CLU_011781_2_4_1; -.
DR InParanoid; L7JXG6; -.
DR OMA; EPGMILS; -.
DR Proteomes; UP000011185; Unassembled WGS sequence.
DR GO; GO:0004177; F:aminopeptidase activity; IEA:UniProtKB-KW.
DR Gene3D; 3.90.230.10; Creatinase/methionine aminopeptidase superfamily; 1.
DR Gene3D; 3.40.350.10; Creatinase/prolidase N-terminal domain; 2.
DR InterPro; IPR029149; Creatin/AminoP/Spt16_NTD.
DR InterPro; IPR036005; Creatinase/aminopeptidase-like.
DR InterPro; IPR000587; Creatinase_N.
DR InterPro; IPR000994; Pept_M24.
DR InterPro; IPR032416; Peptidase_M24_C.
DR PANTHER; PTHR43763; XAA-PRO AMINOPEPTIDASE 1; 1.
DR PANTHER; PTHR43763:SF6; XAA-PRO AMINOPEPTIDASE 1; 1.
DR Pfam; PF01321; Creatinase_N; 1.
DR Pfam; PF16189; Creatinase_N_2; 1.
DR Pfam; PF00557; Peptidase_M24; 1.
DR Pfam; PF16188; Peptidase_M24_C; 1.
DR SUPFAM; SSF55920; Creatinase/aminopeptidase; 1.
DR SUPFAM; SSF53092; Creatinase/prolidase N-terminal domain; 1.
PE 3: Inferred from homology;
KW Aminopeptidase {ECO:0000313|EMBL:ELQ76124.1};
KW Hydrolase {ECO:0000313|EMBL:ELQ76124.1};
KW Protease {ECO:0000313|EMBL:ELQ76124.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000011185}.
FT DOMAIN 35..126
FT /note="Creatinase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF01321"
FT DOMAIN 391..620
FT /note="Peptidase M24"
FT /evidence="ECO:0000259|Pfam:PF00557"
FT DOMAIN 626..685
FT /note="Peptidase M24 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF16188"
SQ SEQUENCE 687 AA; 78759 MW; 325D719A4FB86B05 CRC64;
MTFRTTLNTC NISCMIIFLT DNHMNEYIHK SDNIVTPLTG FTGSTATVLI TSDHNFLYTD
GRYFIQAEKE LKDNFVLKKI DVDQSYLEYI RDNVVGNIGM DVNRVDIKTY KMIKNVLAER
EIIHVRNELF CEYGERTFND VIDLEVVKMK DCIWLFEHKH AKKLVLDILK ERDASEPIAS
ILEKSCRLVS TEKQNNVDQC KRVSNAKDDS SGGLLKKWHS PENIRAILEN SPHESQNEKQ
IIDDILNSSI AGISSDDKIA LLRHSLDDSE CMIISLMDEI AYLLNLRGTD IPYNLLFFSY
MFVDKKNAVL FTNSKNVKRN VCIRSYDEFE CFLDAFYQNT GDIKLNDYTR VYVSLDVNAG
ICIKLGCKAV VSDFIQKLKS VKNTNEIVGI IQANIIDGIA LTRLFVWIKH AFQKDKITEI
QISKKLLEIK RELCTSFANK MKADVNNHGS CIEDSITNKY LSRGCFVSES FESIVGVGSN
AAIIHYKGGD INVENNNVLL MDSGSQFLFG TTDITRTLFL GKSPSKFREY FTRVLKGQIT
SKTLIAPQDR FLQMVCNVAR LYLWNIKCDY RHGTSHGVGH SSLVHESLPF RSIVPHQMFS
VEPGVYLENE FGVRIEDVVM AIGDEYLNIV DLSYVPLQRN LIVKKMLLKS EAKYLNGYND
RVRKVLSPFL NKEERKWVKR QTRRIFV
//
