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Database: UniProt
Entry: L7MZQ3_ANOCA
LinkDB: L7MZQ3_ANOCA
Original site: L7MZQ3_ANOCA 
ID   L7MZQ3_ANOCA            Unreviewed;      1209 AA.
AC   L7MZQ3;
DT   06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT   26-JUN-2013, sequence version 2.
DT   25-OCT-2017, entry version 36.
DE   SubName: Full=Hyperpolarization activated cyclic nucleotide gated potassium channel 4 {ECO:0000313|Ensembl:ENSACAP00000007016};
GN   Name=HCN4 {ECO:0000313|Ensembl:ENSACAP00000007016};
OS   Anolis carolinensis (Green anole) (American chameleon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata;
OC   Toxicofera; Iguania; Dactyloidae; Anolis.
OX   NCBI_TaxID=28377 {ECO:0000313|Ensembl:ENSACAP00000007016, ECO:0000313|Proteomes:UP000001646};
RN   [1] {ECO:0000313|Ensembl:ENSACAP00000007016}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JBL SC #1 {ECO:0000313|Ensembl:ENSACAP00000007016};
RG   The Genome Sequencing Platform;
RA   Di Palma F., Alfoldi J., Heiman D., Young S., Grabherr M., Johnson J.,
RA   Lander E.S., Lindblad-Toh K.;
RT   "The Genome Sequence of Anolis carolinensis (Green Anole Lizard).";
RL   Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Proteomes:UP000001646}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JBL SC #1 {ECO:0000313|Proteomes:UP000001646};
RX   PubMed=21881562; DOI=10.1038/nature10390;
RA   Alfoldi J., Di Palma F., Grabherr M., Williams C., Kong L.,
RA   Mauceli E., Russell P., Lowe C.B., Glor R.E., Jaffe J.D., Ray D.A.,
RA   Boissinot S., Shedlock A.M., Botka C., Castoe T.A., Colbourne J.K.,
RA   Fujita M.K., Moreno R.G., Ten Hallers B.F., Haussler D., Heger A.,
RA   Heiman D., Janes D.E., Johnson J., de Jong P.J., Koriabine M.Y.,
RA   Lara M., Novick P.A., Organ C.L., Peach S.E., Poe S., Pollock D.D.,
RA   de Queiroz K., Sanger T., Searle S., Smith J.D., Smith Z.,
RA   Swofford R., Turner-Maier J., Wade J., Young S., Zadissa A.,
RA   Edwards S.V., Glenn T.C., Schneider C.J., Losos J.B., Lander E.S.,
RA   Breen M., Ponting C.P., Lindblad-Toh K.;
RT   "The genome of the green anole lizard and a comparative analysis with
RT   birds and mammals.";
RL   Nature 477:587-591(2011).
RN   [3] {ECO:0000313|Ensembl:ENSACAP00000007016}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JAN-2013) to UniProtKB.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSACAP00000007016}.
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DR   RefSeq; XP_008119223.1; XM_008121016.2.
DR   STRING; 28377.ENSACAP00000007016; -.
DR   Ensembl; ENSACAT00000007167; ENSACAP00000007016; ENSACAG00000007090.
DR   GeneID; 100560546; -.
DR   CTD; 10021; -.
DR   eggNOG; KOG0498; Eukaryota.
DR   eggNOG; ENOG410XPSE; LUCA.
DR   GeneTree; ENSGT00900000140801; -.
DR   InParanoid; L7MZQ3; -.
DR   OrthoDB; EOG091G0JQU; -.
DR   Proteomes; UP000001646; Unplaced.
DR   Bgee; ENSACAG00000007090; -.
DR   GO; GO:0098855; C:HCN channel complex; IEA:Ensembl.
DR   GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR   GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:Ensembl.
DR   GO; GO:0030552; F:cAMP binding; IEA:InterPro.
DR   GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR   GO; GO:0005222; F:intracellular cAMP activated cation channel activity; IEA:Ensembl.
DR   GO; GO:0005249; F:voltage-gated potassium channel activity; IBA:GO_Central.
DR   GO; GO:0086041; F:voltage-gated potassium channel activity involved in SA node cell action potential depolarization; IEA:Ensembl.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:Ensembl.
DR   GO; GO:0071320; P:cellular response to cAMP; IEA:Ensembl.
DR   GO; GO:0071321; P:cellular response to cGMP; IEA:Ensembl.
DR   GO; GO:1990573; P:potassium ion import across plasma membrane; IEA:Ensembl.
DR   GO; GO:0098909; P:regulation of cardiac muscle cell action potential involved in regulation of contraction; IEA:Ensembl.
DR   GO; GO:0086091; P:regulation of heart rate by cardiac conduction; IEA:Ensembl.
DR   GO; GO:0003254; P:regulation of membrane depolarization; IEA:Ensembl.
DR   GO; GO:0042391; P:regulation of membrane potential; IBA:GO_Central.
DR   GO; GO:0098719; P:sodium ion import across plasma membrane; IEA:Ensembl.
DR   CDD; cd00038; CAP_ED; 1.
DR   Gene3D; 2.60.120.10; -; 1.
DR   InterPro; IPR018490; cNMP-bd-like.
DR   InterPro; IPR018488; cNMP-bd_CS.
DR   InterPro; IPR000595; cNMP-bd_dom.
DR   InterPro; IPR030173; HCN4.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR013621; Ion_trans_N.
DR   InterPro; IPR003938; K_chnl_volt-dep_EAG/ELK/ERG.
DR   InterPro; IPR014710; RmlC-like_jellyroll.
DR   PANTHER; PTHR10217:SF375; PTHR10217:SF375; 1.
DR   Pfam; PF00027; cNMP_binding; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF08412; Ion_trans_N; 1.
DR   PRINTS; PR01463; EAGCHANLFMLY.
DR   SMART; SM00100; cNMP; 1.
DR   SUPFAM; SSF51206; SSF51206; 1.
DR   PROSITE; PS00888; CNMP_BINDING_1; 1.
DR   PROSITE; PS50042; CNMP_BINDING_3; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000001646};
KW   Ion channel {ECO:0000256|SAAS:SAAS00904115};
KW   Ion transport {ECO:0000256|SAAS:SAAS00502700};
KW   Membrane {ECO:0000256|SAAS:SAAS00502630, ECO:0000256|SAM:Phobius};
KW   Potassium {ECO:0000256|SAAS:SAAS00903208};
KW   Potassium channel {ECO:0000256|SAAS:SAAS00904256};
KW   Potassium transport {ECO:0000256|SAAS:SAAS00903350};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001646};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00137614,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00137754,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|SAAS:SAAS00502637};
KW   Voltage-gated channel {ECO:0000256|SAAS:SAAS00903851}.
FT   TRANSMEM    227    251       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    257    276       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    458    481       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      559    674       Cyclic nucleotide-binding.
FT                                {ECO:0000259|PROSITE:PS50042}.
SQ   SEQUENCE   1209 AA;  131019 MW;  7D9D355325640FED CRC64;
     MDKLPPSMRK RLYSLPQQIG NKASLMDEED EGEGGGEGKD ARRKSFKLKP LASQGGEPPG
     SLGEASGGPS SSDGAKNGDC RRFKGSLSSL PGRHHSGEEK RLIGSQGEPA SPGSPPSLGE
     DGAASPSSPS PPPPPPLDGQ QQQQSSSASA SIKVEAPPGS VGGGDQISPE DEQQRGFMHR
     QFGAMLQPGV NKFSLRMFGS QKAVEREQER VKSAGFWIIH PYSDFRFYWD LTMLLLMVGN
     LIIIPVGITF FKDENTTPWI VFNVVSDTFF LIDLVLNFRT GIVVEDNTEI ILDPQRIKMK
     YLKSWFVVDF ISSIPVDYIF LIVETRIDSE VYKTARALRI VRFTKILSLL RLLRLSRLIR
     YIHQWEEIFH MTYDLASAVV RIVNLIGMML LLCHWDGCLQ FLVPMLQDFP DDCWVSLNRM
     VNDSWGKQYS YALFKAMSHM LCIGYGQQAP KGMSDVWLTM LSMIVGATCY AMFIGHATAL
     IQSLDSSRRQ YQEKYKQVEQ YMSFHKLPAE MRQRIHDYYE HRYQGKMFDE ESILGELSEP
     LREEIINFNC RKLVASMPLF ANADPNFVTS MLTKLRFEVF QPADYIIREG TIGKKMYFIQ
     HGVVSVLTKG NKETKLADGS YFGEICLLTR GRRTASVRAD TYCRLYSLSV DNFNEVLEEY
     PMMRRAFETV ALDRLDRIGK KNSILLHKVQ HDLNSGVFNY QENEIIQQIV QHDREMAHCA
     HNVQAAAAAA AAASAPTPVI WTPLIQAPLQ AAAATTSVAI ALTHHPRLPT AIFRPPVSVL
     GSLGQAQNQT PRHLRRFHSL VSSGGPSAMG SPLSTPSQQH TPGAETLSSS SFQIQQLAGF
     TASAGLGQFH RASAGSPSAS SAQQPVGSPS SVGLSQSQLG PSDPPEGSSP QQAFDNNLSS
     GFGPFQKAPT SPPSASAAPF PQQSSNSPSS PLRHLQPTCR PLQVGQAQQA SRTGGLAGMS
     PLPLPPSSSS PSSSLSQLAQ ASGSPPSALC QTQPSALGLS AAPAMVAQLH QERSPFAAST
     SPLKQPMVAP PSYPPSGLSP PHHSPAPRTF QCSPPGSLGS HGSLLMPQAS SPPQQGLQPR
     SSPPLPPGRL TQDLKLISAS QPSLPHEAAL TLSHGSLHSS RESVSSFSSF SGGGGRGGGW
     TIPLGKPYSS VPGRVTLPRQ MSSGSLPHPP TFEATCAISP SLTAADGRKG SIGLTGERES
     VRSKLPSNL
//
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