ID L7N180_MYOLU Unreviewed; 665 AA.
AC L7N180;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2013, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE RecName: Full=Tetratricopeptide repeat protein 30 {ECO:0000256|RuleBase:RU367070};
OS Myotis lucifugus (Little brown bat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC Myotis.
OX NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000004674.2, ECO:0000313|Proteomes:UP000001074};
RN [1] {ECO:0000313|Ensembl:ENSMLUP00000004674.2, ECO:0000313|Proteomes:UP000001074}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSMLUP00000004674.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Required for polyglutamylation of axonemal tubulin. Plays a
CC role in anterograde intraflagellar transport (IFT), the process by
CC which cilia precursors are transported from the base of the cilium to
CC the site of their incorporation at the tip.
CC {ECO:0000256|ARBA:ARBA00002105, ECO:0000256|RuleBase:RU367070}.
CC -!- SUBCELLULAR LOCATION: Cell projection, cilium
CC {ECO:0000256|ARBA:ARBA00004138, ECO:0000256|RuleBase:RU367070}.
CC -!- SIMILARITY: Belongs to the TTC30/dfy-1/fleer family.
CC {ECO:0000256|ARBA:ARBA00009522, ECO:0000256|RuleBase:RU367070}.
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DR EMBL; AAPE02004625; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_006083132.1; XM_006083070.2.
DR AlphaFoldDB; L7N180; -.
DR STRING; 59463.ENSMLUP00000004674; -.
DR Ensembl; ENSMLUT00000005124.2; ENSMLUP00000004674.2; ENSMLUG00000005126.2.
DR GeneID; 102437336; -.
DR KEGG; mlf:102437336; -.
DR eggNOG; KOG4340; Eukaryota.
DR GeneTree; ENSGT00390000010116; -.
DR HOGENOM; CLU_023760_0_0_1; -.
DR InParanoid; L7N180; -.
DR OMA; ANVIQEC; -.
DR OrthoDB; 5477075at2759; -.
DR Proteomes; UP000001074; Unassembled WGS sequence.
DR GO; GO:0005879; C:axonemal microtubule; IEA:UniProtKB-UniRule.
DR GO; GO:0042073; P:intraciliary transport; IEA:UniProtKB-UniRule.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 2.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR InterPro; IPR039941; TT30.
DR PANTHER; PTHR20931:SF0; TETRATRICOPEPTIDE REPEAT PROTEIN 30; 1.
DR PANTHER; PTHR20931; UNCHARACTERIZED; 1.
DR SMART; SM00028; TPR; 4.
DR SUPFAM; SSF48452; TPR-like; 3.
DR PROSITE; PS50005; TPR; 1.
PE 3: Inferred from homology;
KW Cell projection {ECO:0000256|ARBA:ARBA00023273,
KW ECO:0000256|RuleBase:RU367070};
KW Cilium {ECO:0000256|ARBA:ARBA00023069, ECO:0000256|RuleBase:RU367070};
KW Cilium biogenesis/degradation {ECO:0000256|ARBA:ARBA00022794,
KW ECO:0000256|RuleBase:RU367070};
KW Reference proteome {ECO:0000313|Proteomes:UP000001074};
KW TPR repeat {ECO:0000256|PROSITE-ProRule:PRU00339,
KW ECO:0000256|RuleBase:RU367070}.
FT REPEAT 45..78
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
SQ SEQUENCE 665 AA; 76163 MW; 379F1D2F04EF23E6 CRC64;
MAGLGSTPIP DGEFTAAVYR LIRDSRYAEA VQLLGRELQR SPRSRAGLSL LGYCYYRLQE
FPMAAECYEQ LSQLHPELEQ YRLYQAQALY KACLYPEATR VAFLLLDNPA YHSRVLRLQA
AIKYSEGDLP GARSLVEQLL SGEGGEDSGG ENESDSQVNL GCLLYKEGQY QAACSKFFTA
LQASGYRPDL SYNLALAYYS SRQYGPALKH IADIVERGIR QHPELGVGMT TEGIDVHSVG
NTFVLHQTAL VEAFNLKAAI EYQLKNYEVA QEALTDMPPR AEEELDPVTL HNQALMNMDA
RPTEGFEKLQ FLLQQNPFPP ETFGNLLLLY CKYEYFDLAA DVLAENAHLT YKFLTPYLYD
FLDAMITCQT APEEAFIKLD GLAGMLTEQL RKLTVQVQEG RHMRDDEGVK KAVNEYDDIL
EKYIPVLMAQ AKIYWNLENY SMVEKIFRKS VEFCNDHDVW KLNVAHVLFM QENKYKEAIG
FYEPIVKKHY NNILNVSAIV LANLCVSYIM TSQNEEAEEL MRKIEKEEEQ LSYDDPDKKT
YHLCIVNLVI GTLYCAKGNY DFGISRVIKS LEPYNKKLGT DTWYYAKRCF LSLLENMSKH
TVMLRANVIQ ECVQFLEHCE VYGRNVPAVI EQPLEEERMH IGKNTVTYES RQLKALIYEI
IGWNM
//
