ID L7N2B7_MOUSE Unreviewed; 854 AA.
AC L7N2B7;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2013, sequence version 1.
DT 27-MAR-2024, entry version 75.
DE SubName: Full=Vomeronasal 2, receptor 77 {ECO:0000313|Ensembl:ENSMUSP00000129540.2};
GN Name=Vmn2r77 {ECO:0000313|Ensembl:ENSMUSP00000129540.2,
GN ECO:0000313|MGI:MGI:3643879};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000129540.2, ECO:0000313|Proteomes:UP000000589};
RN [1] {ECO:0000313|Ensembl:ENSMUSP00000129540.2, ECO:0000313|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000129540.2,
RC ECO:0000313|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2] {ECO:0000313|Ensembl:ENSMUSP00000129540.2}
RP IDENTIFICATION.
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000129540.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
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DR RefSeq; NP_001098658.1; NM_001105188.1.
DR AlphaFoldDB; L7N2B7; -.
DR SMR; L7N2B7; -.
DR STRING; 10090.ENSMUSP00000129540; -.
DR iPTMnet; L7N2B7; -.
DR PhosphoSitePlus; L7N2B7; -.
DR PaxDb; 10090-ENSMUSP00000129540; -.
DR Ensembl; ENSMUST00000164996.2; ENSMUSP00000129540.2; ENSMUSG00000090949.3.
DR GeneID; 546983; -.
DR KEGG; mmu:546983; -.
DR UCSC; uc012foq.1; mouse.
DR AGR; MGI:3643879; -.
DR CTD; 546983; -.
DR MGI; MGI:3643879; Vmn2r77.
DR VEuPathDB; HostDB:ENSMUSG00000090949; -.
DR eggNOG; KOG1056; Eukaryota.
DR GeneTree; ENSGT00950000183069; -.
DR HOGENOM; CLU_005389_5_0_1; -.
DR InParanoid; L7N2B7; -.
DR OMA; RENKICT; -.
DR OrthoDB; 4188279at2759; -.
DR PhylomeDB; L7N2B7; -.
DR BioGRID-ORCS; 546983; 1 hit in 72 CRISPR screens.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; L7N2B7; Protein.
DR ExpressionAtlas; L7N2B7; differential.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central.
DR CDD; cd15283; 7tmC_V2R_pheromone; 1.
DR CDD; cd06365; PBP1_pheromone_receptor; 1.
DR Gene3D; 3.40.50.2300; -; 2.
DR Gene3D; 2.10.50.30; GPCR, family 3, nine cysteines domain; 1.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR000337; GPCR_3.
DR InterPro; IPR011500; GPCR_3_9-Cys_dom.
DR InterPro; IPR038550; GPCR_3_9-Cys_sf.
DR InterPro; IPR017978; GPCR_3_C.
DR InterPro; IPR000068; GPCR_3_Ca_sens_rcpt-rel.
DR InterPro; IPR004073; GPCR_3_vmron_rcpt_2.
DR InterPro; IPR028082; Peripla_BP_I.
DR PANTHER; PTHR24061; CALCIUM-SENSING RECEPTOR-RELATED; 1.
DR PANTHER; PTHR24061:SF413; VOMERONASAL 2, RECEPTOR 66-RELATED; 1.
DR Pfam; PF00003; 7tm_3; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF07562; NCD3G; 1.
DR PRINTS; PR00248; GPCRMGR.
DR PRINTS; PR01535; VOMERONASL2R.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000000589};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 6..23
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 136..157
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 585..608
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 620..642
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 654..677
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 689..714
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 742..765
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 777..797
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 803..825
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 583..847
FT /note="G-protein coupled receptors family 3 profile"
FT /evidence="ECO:0000259|PROSITE:PS50259"
SQ SEQUENCE 854 AA; 98309 MW; F7F4ED5A3DE52B26 CRC64;
MAEMFSLIVF FLVLKLSFLF CYLSDPRCFW RIKDRENYLG DKEADCFFSI YTKRGYVKND
YFSENLDKKV TLKTIYLISS VYFAIEEINR NIHILPNISL LVKIDCNLIE DNVERVWSLK
KKEIIPNYYC KNQRRYLIVL TGPIWITSYI LGPFLYFSRT PELYCGYFHL LLSDQEQFPH
LYQMTPKDTS LPLAMVSLAV HFRWNWVGVI ITDDDHGIQF LSELRTGMER NTVCLAFVTS
ITYDKMLYLK MTHKYYHQII MSSAKVVVVY GDKESPLQLN FMLWKSINIQ RLWVSVSQFD
MITMMGDFML NSIHGTLIFS HQQSEMSGFK HFIQRVNPSN YSNDISLAKL WWTYFKCSLP
PPDCKTLKNC PTKTLFQWFF EPPLGMSMSE TCYNLYNSVY AAAHSIHEML LQHVDTSSEN
DENVLEFNSW KMFSFVKNIQ FVNPAGDLVN MNQNRKLDTE YDIFYITDFL KHEGLKMKIG
RFSGHFPNGQ QLFISDEMIE WATDIKQTLA SICSVPCRPG LRKYFQEGNS VCCFDCYPCP
ENEISNMTDM DQCVKCPEDE YANTNQTKCF KKVVTFLAYE DPSGMALAVL AVCFSVLTSV
VLCVFLKHRN TPIVKANNET LSYVLLTSLI FCFICSLLYI GYPTMVSCIL QQTTFAIVFT
VAASCVLAKT ITVVLAFKIT VPGRRLRWLL LSGAPNYIIP ICTMIQMILC GIWLGTSPPF
VDADLHMVHG HIIIVCNKGS VIAFYCVLGY MGSLALSSFT VAFLARNLPD TFNEAKLLTF
SMLVFCSVWI TFLPVYHSTK GKAMVAVEVF CILASSAGML VCIFLPKCYI ILLRPQINSF
HDFRKIHVKV ININ
//
