ID L7N322_XENTR Unreviewed; 292 AA.
AC L7N322;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 3.
DT 27-MAR-2024, entry version 41.
DE RecName: Full=Alpha/beta hydrolase domain-containing protein 17C {ECO:0000256|ARBA:ARBA00039756};
DE EC=3.1.2.22 {ECO:0000256|ARBA:ARBA00012423};
GN Name=abhd17c {ECO:0000313|Ensembl:ENSXETP00000018210};
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364 {ECO:0000313|Ensembl:ENSXETP00000018210};
RN [1] {ECO:0000313|Ensembl:ENSXETP00000018210}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Nigerian {ECO:0000313|Ensembl:ENSXETP00000018210};
RX PubMed=20431018; DOI=10.1126/science.1183670;
RA Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J.,
RA Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., Blitz I.L.,
RA Blumberg B., Dichmann D.S., Dubchak I., Amaya E., Detter J.C., Fletcher R.,
RA Gerhard D.S., Goodstein D., Graves T., Grigoriev I.V., Grimwood J.,
RA Kawashima T., Lindquist E., Lucas S.M., Mead P.E., Mitros T., Ogino H.,
RA Ohta Y., Poliakov A.V., Pollet N., Robert J., Salamov A., Sater A.K.,
RA Schmutz J., Terry A., Vize P.D., Warren W.C., Wells D., Wills A.,
RA Wilson R.K., Zimmerman L.B., Zorn A.M., Grainger R., Grammer T.,
RA Khokha M.K., Richardson P.M., Rokhsar D.S.;
RT "The genome of the Western clawed frog Xenopus tropicalis.";
RL Science 328:633-636(2010).
RN [2] {ECO:0000313|Ensembl:ENSXETP00000018210}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JAN-2013) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + S-hexadecanoyl-L-cysteinyl-[protein] = H(+) +
CC hexadecanoate + L-cysteinyl-[protein]; Xref=Rhea:RHEA:19233,
CC Rhea:RHEA-COMP:10131, Rhea:RHEA-COMP:11032, ChEBI:CHEBI:7896,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:29950,
CC ChEBI:CHEBI:74151; EC=3.1.2.22;
CC Evidence={ECO:0000256|ARBA:ARBA00000072};
CC -!- SUBCELLULAR LOCATION: Cell projection, dendritic spine
CC {ECO:0000256|ARBA:ARBA00004552}. Endosome membrane
CC {ECO:0000256|ARBA:ARBA00004238}; Lipid-anchor
CC {ECO:0000256|ARBA:ARBA00004238}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004238}. Membrane
CC {ECO:0000256|ARBA:ARBA00004423}; Lipid-anchor
CC {ECO:0000256|ARBA:ARBA00004423}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004423}. Postsynaptic density membrane
CC {ECO:0000256|ARBA:ARBA00034112}. Recycling endosome membrane
CC {ECO:0000256|ARBA:ARBA00004523}; Lipid-anchor
CC {ECO:0000256|ARBA:ARBA00004523}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004523}.
CC -!- SIMILARITY: Belongs to the AB hydrolase superfamily. ABHD17 family.
CC {ECO:0000256|ARBA:ARBA00038397}.
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DR AlphaFoldDB; L7N322; -.
DR Ensembl; ENSXETT00000018210; ENSXETP00000018210; ENSXETG00000027627.
DR AGR; Xenbase:XB-GENE-6040893; -.
DR Xenbase; XB-GENE-6040893; abhd17c.
DR HOGENOM; CLU_029375_5_4_1; -.
DR Bgee; ENSXETG00000027627; Expressed in 2-cell stage embryo and 13 other cell types or tissues.
DR GO; GO:0043197; C:dendritic spine; IEA:UniProtKB-SubCell.
DR GO; GO:0098839; C:postsynaptic density membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0055038; C:recycling endosome membrane; IEA:UniProtKB-SubCell.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR022742; Hydrolase_4.
DR PANTHER; PTHR12277; ALPHA/BETA HYDROLASE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR12277:SF55; ALPHA_BETA HYDROLASE DOMAIN-CONTAINING PROTEIN 17C; 1.
DR Pfam; PF12146; Hydrolase_4; 1.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
PE 3: Inferred from homology;
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Lipoprotein {ECO:0000256|ARBA:ARBA00023288};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Palmitate {ECO:0000256|ARBA:ARBA00023139};
KW Postsynaptic cell membrane {ECO:0000256|ARBA:ARBA00023257};
KW Synapse {ECO:0000256|ARBA:ARBA00023257}.
FT DOMAIN 95..200
FT /note="Serine aminopeptidase S33"
FT /evidence="ECO:0000259|Pfam:PF12146"
SQ SEQUENCE 292 AA; 32636 MW; 016BAC04193E8834 CRC64;
MPEQGPRMNG FSLGELCWLF CCPPCPSRIA AKLAFLPPEP TYTVGEPAAC SLHLSERADW
QYSQRELDAV EVFRWRTERG SCLGCMFVRC SPGSRYTVLF SHGNAVDLGQ MCSFYIGLGT
RINCNIFSYD YSGYGVSSGK PSEKNLYADI EAAWHALRTR YGVTPENIIL YGQSIGTVPT
VDLASRYECA AVILHSPLMS GLRVAFPDTR KTYCFDAFPS IDKISKVTSP VLIIHGTEDE
VIDFSHGLAM YERCPRAVEP LWVEGAGHND IELYAQYLER LKQFISHELP NS
//
