ID L7RH73_9NEOB Unreviewed; 237 AA.
AC L7RH73;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE RecName: Full=Brain-derived neurotrophic factor {ECO:0000256|ARBA:ARBA00022282, ECO:0000256|RuleBase:RU364086};
DE Short=BDNF {ECO:0000256|RuleBase:RU364086};
DE Flags: Fragment;
GN Name=BDNF {ECO:0000313|EMBL:AGC02510.1};
OS Synapturanus salseri (Timbo disc frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Neobatrachia; Microhyloidea; Microhylidae;
OC Microhylidae incertae sedis; Synapturanus.
OX NCBI_TaxID=1271573 {ECO:0000313|EMBL:AGC02510.1};
RN [1] {ECO:0000313|EMBL:AGC02510.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23228209; DOI=10.1186/1471-2148-12-241;
RA de Sa R.O., Streicher J.W., Sekonyela R., Forlani M.C., Loader S.P.,
RA Greenbaum E., Richards S., Haddad C.F.;
RT "Molecular phylogeny of microhylid frogs (Anura: Microhylidae) with
RT emphasis on relationships among New World genera.";
RL BMC Evol. Biol. 12:241-241(2012).
CC -!- FUNCTION: Promotes the survival of neuronal populations that are all
CC located either in the central nervous system or directly connected to
CC it. {ECO:0000256|RuleBase:RU364086}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|RuleBase:RU364086}.
CC -!- SIMILARITY: Belongs to the NGF-beta family.
CC {ECO:0000256|ARBA:ARBA00010783, ECO:0000256|RuleBase:RU364086}.
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DR EMBL; KC180113; AGC02510.1; -; Genomic_DNA.
DR AlphaFoldDB; L7RH73; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR020430; Brain-der_neurotrophic_factor.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR020408; Nerve_growth_factor-like.
DR InterPro; IPR002072; Nerve_growth_factor-rel.
DR InterPro; IPR019846; Nerve_growth_factor_CS.
DR PANTHER; PTHR11589:SF12; BRAIN-DERIVED NEUROTROPHIC FACTOR; 1.
DR PANTHER; PTHR11589; NERVE GROWTH FACTOR NGF -RELATED; 1.
DR Pfam; PF00243; NGF; 1.
DR PIRSF; PIRSF001789; NGF; 1.
DR PRINTS; PR01912; BDNFACTOR.
DR PRINTS; PR00268; NGF.
DR SMART; SM00140; NGF; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS00248; NGF_1; 1.
DR PROSITE; PS50270; NGF_2; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|PIRSR:PIRSR001789-1};
KW Growth factor {ECO:0000256|RuleBase:RU364086}.
FT DOMAIN 127..234
FT /note="Nerve growth factor-related"
FT /evidence="ECO:0000259|SMART:SM00140"
FT DISULFID 135..202
FT /evidence="ECO:0000256|PIRSR:PIRSR001789-1"
FT DISULFID 180..231
FT /evidence="ECO:0000256|PIRSR:PIRSR001789-1"
FT DISULFID 190..233
FT /evidence="ECO:0000256|PIRSR:PIRSR001789-1"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AGC02510.1"
FT NON_TER 237
FT /evidence="ECO:0000313|EMBL:AGC02510.1"
SQ SEQUENCE 237 AA; 26645 MW; 71140D54AFB488C3 CRC64;
MVISYLSCMK AAPMKEANVR GQSGLAYPGL RTHGTLENIG GPIGGSRGGG LPSLTDTFEQ
VIEELLEEEQ TIRQSEEKKD SDMYTSRVML SSQVPLEPPL LFLLEEYKNY LDAANMSMRV
RRHSDPARRG ELSVCDSISE WVTAADKKTA VDMAGQTVTV LEKVPVPKGQ LKQYFYETKC
NPMGYMKEGC RGIDKRYWNS QCRTTQSYVR ALTMDSKKKV GWRFIRIDTS CVCTLTI
//
