ID L7V8I9_MYCL1 Unreviewed; 353 AA.
AC L7V8I9;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 1.
DT 24-JAN-2024, entry version 34.
DE SubName: Full=Chalcone synthase, Pks11_1 {ECO:0000313|EMBL:AGC62865.1};
DE EC=2.3.1.- {ECO:0000313|EMBL:AGC62865.1};
GN Name=pks11_1 {ECO:0000313|EMBL:AGC62865.1};
GN OrderedLocusNames=MULP_03137 {ECO:0000313|EMBL:AGC62865.1};
OS Mycobacterium liflandii (strain 128FXT).
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycobacterium; Mycobacterium ulcerans group.
OX NCBI_TaxID=459424 {ECO:0000313|EMBL:AGC62865.1, ECO:0000313|Proteomes:UP000011157};
RN [1] {ECO:0000313|EMBL:AGC62865.1, ECO:0000313|Proteomes:UP000011157}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=128FXT {ECO:0000313|EMBL:AGC62865.1,
RC ECO:0000313|Proteomes:UP000011157};
RX PubMed=23204453; DOI=10.1128/JB.02132-12;
RA Tobias N.J., Doig K.D., Medema M.H., Chen H., Haring V., Moore R.,
RA Seemann T., Stinear T.P.;
RT "Complete Genome Sequence of the Frog Pathogen Mycobacterium ulcerans
RT Ecovar Liflandii.";
RL J. Bacteriol. 195:556-564(2013).
CC -!- PATHWAY: Lipid metabolism; fatty acid biosynthesis.
CC {ECO:0000256|ARBA:ARBA00005194}.
CC -!- SUBUNIT: Homodimer. {ECO:0000256|ARBA:ARBA00011738}.
CC -!- SIMILARITY: Belongs to the thiolase-like superfamily. Chalcone/stilbene
CC synthases family. {ECO:0000256|ARBA:ARBA00005531}.
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DR EMBL; CP003899; AGC62865.1; -; Genomic_DNA.
DR RefSeq; WP_015355952.1; NC_020133.1.
DR AlphaFoldDB; L7V8I9; -.
DR KEGG; mli:MULP_03137; -.
DR PATRIC; fig|459424.11.peg.3235; -.
DR HOGENOM; CLU_034992_0_1_11; -.
DR UniPathway; UPA00094; -.
DR Proteomes; UP000011157; Chromosome.
DR GO; GO:0016747; F:acyltransferase activity, transferring groups other than amino-acyl groups; IEA:InterPro.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:UniProtKB-UniPathway.
DR CDD; cd00831; CHS_like; 1.
DR Gene3D; 3.40.47.10; -; 2.
DR InterPro; IPR012328; Chalcone/stilbene_synt_C.
DR InterPro; IPR001099; Chalcone/stilbene_synt_N.
DR InterPro; IPR011141; Polyketide_synthase_type-III.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR11877:SF99; 1,3,6,8-TETRAHYDROXYNAPHTHALENE SYNTHASE; 1.
DR PANTHER; PTHR11877; HYDROXYMETHYLGLUTARYL-COA SYNTHASE; 1.
DR Pfam; PF02797; Chal_sti_synt_C; 1.
DR Pfam; PF00195; Chal_sti_synt_N; 1.
DR PIRSF; PIRSF000451; PKS_III; 1.
DR SUPFAM; SSF53901; Thiolase-like; 1.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000313|EMBL:AGC62865.1};
KW Fatty acid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Transferase {ECO:0000313|EMBL:AGC62865.1}.
FT DOMAIN 9..197
FT /note="Chalcone/stilbene synthase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00195"
FT DOMAIN 219..351
FT /note="Chalcone/stilbene synthase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02797"
FT ACT_SITE 138
FT /note="Acyl-thioester intermediate"
FT /evidence="ECO:0000256|PIRSR:PIRSR000451-1"
SQ SEQUENCE 353 AA; 37471 MW; CD9F0B5AF534E23B CRC64;
MSVIAGVFGA LPPHRYSQSE ITESFLEFPG LQEHEEIVRR MHAAAKVNSR QFVLPIEQYP
ALTDFGDANE IFIEKAVDLG IEALMGALDE AGLTPQDIDL IITTTVTGVA VPSLDARIAG
RLGLRPDVRR MPLFGLGCVA GAAGVARLHD YLRGAPDGVA VLIAVELCSL TYPAVKPTVS
GIVGTALFGD GAAAVVAVGD RRAEQIRAGG PDILDSRSRL YPESLDIMGW DVGSHGLQLR
LAPELTNLIE EYLPDDVDAF LAMHDLTKND IGAWVSHPGG PKVLDAIANS LGLPSDALEL
TWRSLGEIGN LSSASVLHIL RDTIAKVPPS GSPGLMLAMG PGFCAELVLL RWH
//
