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Database: UniProt
Entry: L7W8J0_NONDD
LinkDB: L7W8J0_NONDD
Original site: L7W8J0_NONDD 
ID   L7W8J0_NONDD            Unreviewed;       220 AA.
AC   L7W8J0;
DT   03-APR-2013, integrated into UniProtKB/TrEMBL.
DT   03-APR-2013, sequence version 1.
DT   27-MAR-2024, entry version 43.
DE   RecName: Full=Peptidyl-tRNA hydrolase {ECO:0000256|ARBA:ARBA00013260, ECO:0000256|HAMAP-Rule:MF_00083};
DE            Short=PTH {ECO:0000256|HAMAP-Rule:MF_00083};
DE            EC=3.1.1.29 {ECO:0000256|ARBA:ARBA00013260, ECO:0000256|HAMAP-Rule:MF_00083};
GN   Name=pth {ECO:0000256|HAMAP-Rule:MF_00083,
GN   ECO:0000313|EMBL:AGC76126.1};
GN   OrderedLocusNames=DDD_0999 {ECO:0000313|EMBL:AGC76126.1};
OS   Nonlabens dokdonensis (strain DSM 17205 / KCTC 12402 / DSW-6) (Donghaeana
OS   dokdonensis).
OC   Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales;
OC   Flavobacteriaceae; Nonlabens.
OX   NCBI_TaxID=592029 {ECO:0000313|EMBL:AGC76126.1, ECO:0000313|Proteomes:UP000011173};
RN   [1] {ECO:0000313|EMBL:AGC76126.1, ECO:0000313|Proteomes:UP000011173}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 17205 / KCTC 12402 / DSW-6
RC   {ECO:0000313|Proteomes:UP000011173};
RX   PubMed=23292138; DOI=10.1093/gbe/evs134;
RA   Kwon S.K., Kim B.K., Song J.Y., Kwak M.J., Lee C.H., Yoon J.H., Oh T.K.,
RA   Kim J.F.;
RT   "Genomic makeup of the marine flavobacterium Nonlabens (Donghaeana)
RT   dokdonensis DSW-6 and identification of a novel class of rhodopsins.";
RL   Genome Biol. Evol. 5:187-187(2013).
CC   -!- FUNCTION: The natural substrate for this enzyme may be peptidyl-tRNAs
CC       which drop off the ribosome during protein synthesis.
CC       {ECO:0000256|HAMAP-Rule:MF_00083}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=an N-acyl-L-alpha-aminoacyl-tRNA + H2O = a tRNA + an N-acyl-L-
CC         amino acid + H(+); Xref=Rhea:RHEA:54448, Rhea:RHEA-COMP:10123,
CC         Rhea:RHEA-COMP:13883, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:59874, ChEBI:CHEBI:78442, ChEBI:CHEBI:138191;
CC         EC=3.1.1.29; Evidence={ECO:0000256|HAMAP-Rule:MF_00083,
CC         ECO:0000256|RuleBase:RU000673};
CC   -!- SUBUNIT: Monomer. {ECO:0000256|HAMAP-Rule:MF_00083}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00083}.
CC   -!- SIMILARITY: Belongs to the PTH family. {ECO:0000256|ARBA:ARBA00038063,
CC       ECO:0000256|HAMAP-Rule:MF_00083, ECO:0000256|RuleBase:RU004320}.
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DR   EMBL; CP001397; AGC76126.1; -; Genomic_DNA.
DR   AlphaFoldDB; L7W8J0; -.
DR   STRING; 592029.DDD_0999; -.
DR   KEGG; ndo:DDD_0999; -.
DR   PATRIC; fig|592029.3.peg.991; -.
DR   eggNOG; COG0193; Bacteria.
DR   HOGENOM; CLU_062456_4_1_10; -.
DR   Proteomes; UP000011173; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0004045; F:aminoacyl-tRNA hydrolase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006412; P:translation; IEA:UniProtKB-UniRule.
DR   CDD; cd00462; PTH; 1.
DR   Gene3D; 3.40.50.1470; Peptidyl-tRNA hydrolase; 1.
DR   HAMAP; MF_00083; Pept_tRNA_hydro_bact; 1.
DR   InterPro; IPR001328; Pept_tRNA_hydro.
DR   InterPro; IPR018171; Pept_tRNA_hydro_CS.
DR   InterPro; IPR036416; Pept_tRNA_hydro_sf.
DR   NCBIfam; TIGR00447; pth; 1.
DR   PANTHER; PTHR17224; PEPTIDYL-TRNA HYDROLASE; 1.
DR   PANTHER; PTHR17224:SF1; PEPTIDYL-TRNA HYDROLASE-RELATED; 1.
DR   Pfam; PF01195; Pept_tRNA_hydro; 1.
DR   SUPFAM; SSF53178; Peptidyl-tRNA hydrolase-like; 1.
DR   PROSITE; PS01195; PEPT_TRNA_HYDROL_1; 1.
PE   3: Inferred from homology;
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00083};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|HAMAP-Rule:MF_00083}.
SQ   SEQUENCE   220 AA;  24890 MW;  E4685815D0B222D7 CRC64;
     MQLFYFYNML NWFKKIFTRD ARITTVLNEE DSMKKFLIVG LGNPGAKYSE TRHNIGFKIL
     DEIATEKEAS FETLKLGDVA SITHKGKSVL LLKPNTFMNL SGKAIKYYMK QEGISIDNIL
     VITDDLNLPF GTLRMKAKGT DGGHNGLKDT QITLNTPKYP RLRFGISDEF SKGRQVDYVL
     GEWNSEEQKS LPERLDTAAK MALSFTHAGL ANTMNQYNGK
//
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