ID L7YDI2_CALMI Unreviewed; 399 AA.
AC L7YDI2;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 1.
DT 27-MAR-2024, entry version 51.
DE SubName: Full=WT1 transcription factor {ECO:0000313|Ensembl:ENSCMIP00000043610.1};
DE SubName: Full=Wilms tumor 1 {ECO:0000313|EMBL:AGD98723.1};
GN Name=Wt1 {ECO:0000313|EMBL:AGD98723.1};
GN Synonyms=wt1 {ECO:0000313|Ensembl:ENSCMIP00000043610.1};
OS Callorhinchus milii (Ghost shark).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Chondrichthyes;
OC Holocephali; Chimaeriformes; Callorhinchidae; Callorhinchus.
OX NCBI_TaxID=7868 {ECO:0000313|EMBL:AGD98723.1};
RN [1] {ECO:0000313|Proteomes:UP000314986}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=17185593; DOI=10.1126/science.1130708;
RA Venkatesh B., Kirkness E.F., Loh Y.H., Halpern A.L., Lee A.P., Johnson J.,
RA Dandona N., Viswanathan L.D., Tay A., Venter J.C., Strausberg R.L.,
RA Brenner S.;
RT "Ancient noncoding elements conserved in the human genome.";
RL Science 314:1892-1892(2006).
RN [2] {ECO:0000313|Proteomes:UP000314986}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=17407382;
RA Venkatesh B., Kirkness E.F., Loh Y.H., Halpern A.L., Lee A.P., Johnson J.,
RA Dandona N., Viswanathan L.D., Tay A., Venter J.C., Strausberg R.L.,
RA Brenner S.;
RT "Survey sequencing and comparative analysis of the elephant shark
RT (Callorhinchus milii) genome.";
RL PLoS Biol. 5:E101-E101(2007).
RN [3] {ECO:0000313|EMBL:AGD98723.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23359656; DOI=10.1371/journal.pgen.1003177;
RA Ravi V., Bhatia S., Gautier P., Loosli F., Tay B.-H., Tay A., Murdoch E.,
RA Coutinho P., van Heyningen V., Brenner S., Venkatesh B., Kleinjan D.A.;
RT "Sequencing of pax6 Loci from the elephant shark reveals a family of pax6
RT genes in vertebrate genomes, forged by ancient duplications and
RT divergences.";
RL PLoS Genet. 9:E1003177-E1003177(2013).
RN [4] {ECO:0000313|EMBL:AFO94236.1, ECO:0000313|Proteomes:UP000314986}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Testis {ECO:0000313|EMBL:AFO94236.1};
RX PubMed=24402279; DOI=10.1038/nature12826;
RG International Elephant Shark Genome Sequencing Consortium;
RA Venkatesh B., Lee A.P., Ravi V., Maurya A.K., Lian M.M., Swann J.B.,
RA Ohta Y., Flajnik M.F., Sutoh Y., Kasahara M., Hoon S., Gangu V., Roy S.W.,
RA Irimia M., Korzh V., Kondrychyn I., Lim Z.W., Tay B.H., Tohari S.,
RA Kong K.W., Ho S., Lorente-Galdos B., Quilez J., Marques-Bonet T.,
RA Raney B.J., Ingham P.W., Tay A., Hillier L.W., Minx P., Boehm T.,
RA Wilson R.K., Brenner S., Warren W.C.;
RT "Elephant shark genome provides unique insights into gnathostome
RT evolution.";
RL Nature 505:174-179(2014).
RN [5] {ECO:0000313|Ensembl:ENSCMIP00000043610.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus speckle {ECO:0000256|ARBA:ARBA00004324}.
CC -!- SIMILARITY: Belongs to the EGR C2H2-type zinc-finger protein family.
CC {ECO:0000256|ARBA:ARBA00005682}.
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DR EMBL; JW861719; AFO94236.1; -; mRNA.
DR EMBL; JX135563; AGD98723.1; -; Genomic_DNA.
DR RefSeq; XP_007885965.1; XM_007887774.1.
DR STRING; 7868.ENSCMIP00000043610; -.
DR Ensembl; ENSCMIT00000044234.1; ENSCMIP00000043610.1; ENSCMIG00000018077.1.
DR GeneID; 103175043; -.
DR KEGG; cmk:103175043; -.
DR CTD; 568416; -.
DR GeneTree; ENSGT00940000156734; -.
DR OMA; GQSNHTT; -.
DR OrthoDB; 2898220at2759; -.
DR Proteomes; UP000314986; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0016607; C:nuclear speck; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 4.
DR InterPro; IPR000976; Wilms_tumour_N.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR23235:SF71; KRUEPPEL-LIKE FACTOR 16; 1.
DR PANTHER; PTHR23235; KRUEPPEL-LIKE TRANSCRIPTION FACTOR; 1.
DR Pfam; PF02165; WT1; 2.
DR Pfam; PF00096; zf-C2H2; 2.
DR PRINTS; PR00049; WILMSTUMOUR.
DR SMART; SM00355; ZnF_C2H2; 4.
DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 2.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 4.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 4.
PE 2: Evidence at transcript level;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000314986};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00042}.
FT DOMAIN 273..302
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 303..332
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 333..360
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 364..393
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
SQ SEQUENCE 399 AA; 44258 MW; CB8EDA1DB797A169 CRC64;
MGSDVRDLNA LLPAVSTLSP GSGSCSMPVG SAPQWAPVLD FHPGAAYSAP MGHPSFIKQE
PTWSASAAGA VAEPHDDHCL SAFTVHFSGQ FTGTAGACRY GAFGAPPPTQ APPSQARMFS
NNAYLNHCMD TQPPARNHGY GAVAFDGTPS YSHPSTHHAP QFSNHPFKHE DPINQQNSIG
DQQYGVPPPV YGCHTPTDSC AGSQALLLRS PYNSHAAAYE NDNHNAPMLY SCSTQYRIHT
HGVFRGIQDV RRVPGVTPAI VRSNAESSEK RPFMCPYPGC SKRYFKLSHL QMHSRKHTGE
KPYQCDFKDC GRRFSRSDQL KRHQRRHTGV KPFQCKTCQR KFSRSDHLKT HTRTHTGKTS
EKPFSCRWPS CQKKFARSDE LVRHHNMHQR NLTKLQLAL
//
