ID L8A2K9_9BACI Unreviewed; 221 AA.
AC L8A2K9;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE RecName: Full=D-lactate dehydratase {ECO:0000256|ARBA:ARBA00013134};
DE EC=4.2.1.130 {ECO:0000256|ARBA:ARBA00013134};
GN ORFNames=GHH_c27800 {ECO:0000313|EMBL:AGE23291.1};
OS Geobacillus sp. GHH01.
OC Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Geobacillus.
OX NCBI_TaxID=1233873 {ECO:0000313|EMBL:AGE23291.1, ECO:0000313|Proteomes:UP000011251};
RN [1] {ECO:0000313|EMBL:AGE23291.1, ECO:0000313|Proteomes:UP000011251}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=GHH01 {ECO:0000313|EMBL:AGE23291.1};
RX PubMed=23618712;
RA Wiegand S., Rabausch U., Chow J., Daniel R., Streit W.R., Liesegang H.;
RT "Complete Genome Sequence of Geobacillus sp. Strain GHH01, a Thermophilic
RT Lipase-Secreting Bacterium.";
RL Genome Announc. 1:E0009213-E0009213(2013).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + methylglyoxal = (R)-lactate + H(+);
CC Xref=Rhea:RHEA:27754, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:16004, ChEBI:CHEBI:17158; EC=4.2.1.130;
CC Evidence={ECO:0000256|ARBA:ARBA00001524};
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DR EMBL; CP004008; AGE23291.1; -; Genomic_DNA.
DR RefSeq; WP_015375566.1; NC_020210.1.
DR AlphaFoldDB; L8A2K9; -.
DR KEGG; ggh:GHH_c27800; -.
DR PATRIC; fig|1233873.3.peg.2983; -.
DR HOGENOM; CLU_070319_1_1_9; -.
DR Proteomes; UP000011251; Chromosome.
DR CDD; cd03141; GATase1_Hsp31_like; 1.
DR Gene3D; 3.40.50.880; -; 1.
DR InterPro; IPR029062; Class_I_gatase-like.
DR InterPro; IPR002818; DJ-1/PfpI.
DR PANTHER; PTHR48094:SF11; GLUTATHIONE-INDEPENDENT GLYOXALASE HSP31-RELATED; 1.
DR PANTHER; PTHR48094; PROTEIN/NUCLEIC ACID DEGLYCASE DJ-1-RELATED; 1.
DR Pfam; PF01965; DJ-1_PfpI; 1.
DR SUPFAM; SSF52317; Class I glutamine amidotransferase-like; 1.
PE 4: Predicted;
KW Stress response {ECO:0000256|ARBA:ARBA00023016}.
FT DOMAIN 27..215
FT /note="DJ-1/PfpI"
FT /evidence="ECO:0000259|Pfam:PF01965"
SQ SEQUENCE 221 AA; 24450 MW; ED4CD03CD18EDB52 CRC64;
MTKRVLMVVT NHTTITDDHK TGLWLEEFAV PYLVFKEKGY DVKVASIQGG EVPLDPRSIN
EKDPSWAEAE AVLKNTTRLS KDDAHGFDAI FLPGGHGTMF DFPDNETLQY VLQQFAEDGR
IIAAVCHGPS GLVNATYKDG TPIVKGKTVT SFTDEEEREV GLDVHMPFLL ESTLRLRGAN
FVHGEKWTDF SVRDGNLITG QNPQSSRSTA EKVVAALEER A
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