ID L8AXE0_IDIPA Unreviewed; 408 AA.
AC L8AXE0;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 1.
DT 08-NOV-2023, entry version 55.
DE SubName: Full=Pax-6 variant form1 {ECO:0000313|EMBL:BAM74251.1};
GN Name=Pax-6 {ECO:0000313|EMBL:BAM74251.1};
OS Idiosepius paradoxus (Northern pygmy squid).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Cephalopoda;
OC Coleoidea; Decapodiformes; Decapodiformes incertae sedis; Idiosepiidae;
OC Idiosepius.
OX NCBI_TaxID=294707 {ECO:0000313|EMBL:BAM74251.1};
RN [1] {ECO:0000313|EMBL:BAM74251.1}
RP NUCLEOTIDE SEQUENCE.
RA Yoshida M., Ogura A.;
RL Submitted (MAY-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:BAM74251.1}
RP NUCLEOTIDE SEQUENCE.
RA Yoshida M.A., Yura K., Ogura A.;
RT "Pax-6 splicing variants contributed to cephalopod camera eye evolution.";
RL Submitted (JAN-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PROSITE-ProRule:PRU00108, ECO:0000256|RuleBase:RU000682}.
CC -!- SIMILARITY: Belongs to the paired homeobox family.
CC {ECO:0000256|ARBA:ARBA00005733}.
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DR EMBL; AB716345; BAM74251.1; -; Genomic_DNA.
DR AlphaFoldDB; L8AXE0; -.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR GO; GO:0048856; P:anatomical structure development; IEA:UniProt.
DR CDD; cd00086; homeodomain; 1.
DR CDD; cd00131; PAX; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 2.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR043182; PAIRED_DNA-bd_dom.
DR InterPro; IPR001523; Paired_dom.
DR InterPro; IPR043565; PAX_fam.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR45636:SF41; PAIRED BOX PROTEIN PAX-6; 1.
DR PANTHER; PTHR45636; PAIRED BOX PROTEIN PAX-6-RELATED-RELATED; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR Pfam; PF00292; PAX; 1.
DR PRINTS; PR00027; PAIREDBOX.
DR SMART; SM00389; HOX; 1.
DR SMART; SM00351; PAX; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 2.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
DR PROSITE; PS00034; PAIRED_1; 1.
DR PROSITE; PS51057; PAIRED_2; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Homeobox {ECO:0000256|ARBA:ARBA00023155, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00108}; Paired box {ECO:0000256|ARBA:ARBA00022724};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 11..137
FT /note="Paired"
FT /evidence="ECO:0000259|PROSITE:PS51057"
FT DOMAIN 197..239
FT /note="Homeobox"
FT /evidence="ECO:0000259|PROSITE:PS50071"
FT DNA_BIND 199..240
FT /note="Homeobox"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT REGION 384..408
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 391..408
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 408 AA; 44836 MW; C0BC3B09CE7B3A03 CRC64;
MQEKNFSTNG GHSGVNQLGG VFVNGRPLPD STRQRIVELA HSGARPCDIS RILQVSNGCV
SKILGRYYET GSIRPRAIGG SKPRVATPEV VQKIAQFKRE CPSIFAWEVR DRLLSEGVCT
QDNIPSVSSI NRVLRNLAGE NQKVLGQGTT MYDKLGLLNG QAWPRPNPWY APNASMAGLS
APSSYTQPNP PSTVAGKKEF ERTHYPDVFV RERLAQKIDL PEARIQVWFS NRRARWRREE
RLRNQRREAA NGSTRLPINS SFPHSMYPTI NQPLASMAES YRDLKGWDVA GGLGSMPTVP
NYSLSNNITG NPACLQSNAS SYSCMLPDYV SGTARRYDPL SLSNYSRSSC NPAAGMQSHM
TPHSTNGAST GLISPGVSVP IQVPGGGPQD MSTHHMSSMT SQYWPRLQ
//
