ID L8FWY5_PSED2 Unreviewed; 357 AA.
AC L8FWY5;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 1.
DT 24-JAN-2024, entry version 33.
DE SubName: Full=Homoisocitrate dehydrogenase {ECO:0000313|EMBL:ELR05412.1};
GN ORFNames=GMDG_01707 {ECO:0000313|EMBL:ELR05412.1};
OS Pseudogymnoascus destructans (strain ATCC MYA-4855 / 20631-21) (Bat
OS white-nose syndrome fungus) (Geomyces destructans).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Leotiomycetes incertae sedis; Pseudeurotiaceae; Pseudogymnoascus.
OX NCBI_TaxID=658429 {ECO:0000313|EMBL:ELR05412.1, ECO:0000313|Proteomes:UP000011064};
RN [1] {ECO:0000313|Proteomes:UP000011064}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4855 / 20631-21 {ECO:0000313|Proteomes:UP000011064};
RG The Broad Institute Genome Sequencing Platform;
RA Cuomo C.A., Blehert D.S., Lorch J.M., Young S.K., Zeng Q., Gargeya S.,
RA Fitzgerald M., Haas B., Abouelleil A., Alvarado L., Arachchi H.M.,
RA Berlin A., Brown A., Chapman S.B., Chen Z., Dunbar C., Freedman E.,
RA Gearin G., Gellesch M., Goldberg J., Griggs A., Gujja S., Heiman D.,
RA Howarth C., Larson L., Lui A., MacDonald P.J.P., Montmayeur A., Murphy C.,
RA Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T., Shenoy N.,
RA Sisk P., Stolte C., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT "The genome sequence of Geomyces destructans 20631-21.";
RL Submitted (SEP-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the isocitrate and isopropylmalate
CC dehydrogenases family. {ECO:0000256|ARBA:ARBA00007769}.
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DR EMBL; GL573190; ELR05412.1; -; Genomic_DNA.
DR RefSeq; XP_012740106.1; XM_012884652.1.
DR AlphaFoldDB; L8FWY5; -.
DR STRING; 658429.L8FWY5; -.
DR VEuPathDB; FungiDB:GMDG_01707; -.
DR HOGENOM; CLU_031953_0_1_1; -.
DR InParanoid; L8FWY5; -.
DR OrthoDB; 143577at2759; -.
DR Proteomes; UP000011064; Unassembled WGS sequence.
DR GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR Gene3D; 3.40.718.10; Isopropylmalate Dehydrogenase; 1.
DR InterPro; IPR019818; IsoCit/isopropylmalate_DH_CS.
DR InterPro; IPR024084; IsoPropMal-DH-like_dom.
DR PANTHER; PTHR11835; DECARBOXYLATING DEHYDROGENASES-ISOCITRATE, ISOPROPYLMALATE, TARTRATE; 1.
DR PANTHER; PTHR11835:SF48; HOMOISOCITRATE DEHYDROGENASE, MITOCHONDRIAL; 1.
DR Pfam; PF00180; Iso_dh; 1.
DR SMART; SM01329; Iso_dh; 1.
DR SUPFAM; SSF53659; Isocitrate/Isopropylmalate dehydrogenase-like; 1.
DR PROSITE; PS00470; IDH_IMDH; 1.
PE 3: Inferred from homology;
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Reference proteome {ECO:0000313|Proteomes:UP000011064}.
FT DOMAIN 7..353
FT /note="Isopropylmalate dehydrogenase-like"
FT /evidence="ECO:0000259|SMART:SM01329"
SQ SEQUENCE 357 AA; 38061 MW; 88A42333AE5B11AE CRC64;
MATRTLRIGL IPGDGIGKEV IPAGRRLLEA LPASLGLKFD FVDLKAGFET FEQTGTALPD
KTVETLKHEC DGALFGAVQS PSTAVKGYSS PIVALRKRLD LYANVRPVKS VMTAANPIDM
VIVRENTEDL YVKEERTFTA PDGSLVAEAI KRISQKASHR IALIAAEIAQ SRQRIRDAGA
PSIHSAPLVT ITHKSNVLSQ TDGLFRTTAR EALALPQFKG VGVEEQIVDS MVYKLFRQPE
TYDVIVAPNL YGDILSDGAA ALVGSLGLVP SANVGEGFAI GEPCHGSAPD IAGQDIANPI
ATLRSVALML EFLKEETAAA LIYKAVDANL TEGKYLSPDL GGTAKTSEVV ADILRRL
//
