ID L8G1H0_PSED2 Unreviewed; 743 AA.
AC L8G1H0;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 1.
DT 13-SEP-2023, entry version 44.
DE RecName: Full=Arf-GAP domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=GMDG_08102 {ECO:0000313|EMBL:ELR06629.1};
OS Pseudogymnoascus destructans (strain ATCC MYA-4855 / 20631-21) (Bat
OS white-nose syndrome fungus) (Geomyces destructans).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Leotiomycetes incertae sedis; Pseudeurotiaceae; Pseudogymnoascus.
OX NCBI_TaxID=658429 {ECO:0000313|EMBL:ELR06629.1, ECO:0000313|Proteomes:UP000011064};
RN [1] {ECO:0000313|Proteomes:UP000011064}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4855 / 20631-21 {ECO:0000313|Proteomes:UP000011064};
RG The Broad Institute Genome Sequencing Platform;
RA Cuomo C.A., Blehert D.S., Lorch J.M., Young S.K., Zeng Q., Gargeya S.,
RA Fitzgerald M., Haas B., Abouelleil A., Alvarado L., Arachchi H.M.,
RA Berlin A., Brown A., Chapman S.B., Chen Z., Dunbar C., Freedman E.,
RA Gearin G., Gellesch M., Goldberg J., Griggs A., Gujja S., Heiman D.,
RA Howarth C., Larson L., Lui A., MacDonald P.J.P., Montmayeur A., Murphy C.,
RA Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T., Shenoy N.,
RA Sisk P., Stolte C., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT "The genome sequence of Geomyces destructans 20631-21.";
RL Submitted (SEP-2010) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; GL573467; ELR06629.1; -; Genomic_DNA.
DR RefSeq; XP_012746561.1; XM_012891107.1.
DR AlphaFoldDB; L8G1H0; -.
DR STRING; 658429.L8G1H0; -.
DR VEuPathDB; FungiDB:GMDG_08102; -.
DR HOGENOM; CLU_017628_0_0_1; -.
DR InParanoid; L8G1H0; -.
DR OrthoDB; 1022106at2759; -.
DR Proteomes; UP000011064; Unassembled WGS sequence.
DR GO; GO:0005096; F:GTPase activator activity; IEA:InterPro.
DR CDD; cd08204; ArfGap; 1.
DR Gene3D; 1.10.220.150; Arf GTPase activating protein; 1.
DR Gene3D; 1.10.8.10; DNA helicase RuvA subunit, C-terminal domain; 1.
DR InterPro; IPR037278; ARFGAP/RecO.
DR InterPro; IPR001164; ArfGAP_dom.
DR InterPro; IPR038508; ArfGAP_dom_sf.
DR InterPro; IPR015940; UBA.
DR InterPro; IPR009060; UBA-like_sf.
DR PANTHER; PTHR45705:SF7; ACTIVATING PROTEIN FOR ARF, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G09120)-RELATED; 1.
DR PANTHER; PTHR45705; FI20236P1; 1.
DR Pfam; PF01412; ArfGap; 1.
DR PRINTS; PR00405; REVINTRACTNG.
DR SMART; SM00105; ArfGap; 1.
DR SUPFAM; SSF57863; ArfGap/RecO-like zinc finger; 1.
DR SUPFAM; SSF46934; UBA-like; 1.
DR PROSITE; PS50115; ARFGAP; 1.
DR PROSITE; PS50030; UBA; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00288};
KW Reference proteome {ECO:0000313|Proteomes:UP000011064};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00288};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00288}.
FT DOMAIN 14..124
FT /note="Arf-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50115"
FT DOMAIN 254..295
FT /note="UBA"
FT /evidence="ECO:0000259|PROSITE:PS50030"
FT REGION 126..193
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 215..371
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 445..466
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 510..547
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 591..743
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 138..182
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 220..235
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 251..272
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 302..330
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 338..371
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 611..677
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 704..719
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 743 AA; 81765 MW; B6A239E95BD3AB1C CRC64;
MSSGLSKRQQ ARNERTLQNL VKSVPGNSTC ADCGARNPGW ASWSLGIFLC VRCAAVHRGL
GTHISKVKSL SMDSWSNEQV ENMKQRGNTM SNLIYNPKNT RPPLPVDADE VDSAVERFIR
NKYKNSAPAT NYDDSRDYET STAYREPESN RREPEPVRRE TTSNSHRRTG STDSDDEHPL
PAPPQKSRFG FRSASSIFPM SSKAKREAAA RVYLENQSRN DNARWDDDEG PPPPRKGKPA
RIFGSSNASD RSVEEWEKKL SQLREMGFKN DKRNSTVLKG FNGNMDKTLE TLVRLGEREA
PSRSRTPSTA PLSAGLLINP SKDSPASPTP SKNPWDMPSA PPQSSQSTGA LSLQEQQSKN
NPQQASLNPF GFATSKSQYN LNQQYTNVEQ PFQNMSISPN QPLFPHHTGG TAQRQPFMAA
AAPSMPSIPQ GQYAPSPYGA QLQTQYSPTT SPGHNPFLQQ QPTRQTQSLN VTPLTATAPN
PFHTLTRNQT FPMQQGSQAQ PQMSMQDYFN SGQQQQQPQL NPYSQQQTPQ QPNPFNQMQQ
PQQQQQLQRL NPYNQPQLMQ QQLNPYNNFQ QQPQQLLPQQ TGRADKTSIM ALYGSNPQSP
PLPSPQPQQQ PQFANQPQQL TQNPYQPQLV NTNQQFGNPT QQQPGLSSPL SSSVSFGGSK
NPFMHGSSTN PSPFAQPNQA AGGAPHGGLL AASGVGGIGS ANGGNPSRHV SQESMSVDPN
GWHAHSGRHS PDAFASLSSR AVR
//
