ID L8G3U6_PSED2 Unreviewed; 674 AA.
AC L8G3U6;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE RecName: Full=Mediator of RNA polymerase II transcription subunit 1 {ECO:0000256|RuleBase:RU364059};
DE AltName: Full=Mediator complex subunit 1 {ECO:0000256|RuleBase:RU364059};
GN ORFNames=GMDG_02809 {ECO:0000313|EMBL:ELR07950.1};
OS Pseudogymnoascus destructans (strain ATCC MYA-4855 / 20631-21) (Bat
OS white-nose syndrome fungus) (Geomyces destructans).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Leotiomycetes incertae sedis; Pseudeurotiaceae; Pseudogymnoascus.
OX NCBI_TaxID=658429 {ECO:0000313|EMBL:ELR07950.1, ECO:0000313|Proteomes:UP000011064};
RN [1] {ECO:0000313|Proteomes:UP000011064}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4855 / 20631-21 {ECO:0000313|Proteomes:UP000011064};
RG The Broad Institute Genome Sequencing Platform;
RA Cuomo C.A., Blehert D.S., Lorch J.M., Young S.K., Zeng Q., Gargeya S.,
RA Fitzgerald M., Haas B., Abouelleil A., Alvarado L., Arachchi H.M.,
RA Berlin A., Brown A., Chapman S.B., Chen Z., Dunbar C., Freedman E.,
RA Gearin G., Gellesch M., Goldberg J., Griggs A., Gujja S., Heiman D.,
RA Howarth C., Larson L., Lui A., MacDonald P.J.P., Montmayeur A., Murphy C.,
RA Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T., Shenoy N.,
RA Sisk P., Stolte C., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT "The genome sequence of Geomyces destructans 20631-21.";
RL Submitted (SEP-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC the regulated transcription of nearly all RNA polymerase II-dependent
CC genes. Mediator functions as a bridge to convey information from gene-
CC specific regulatory proteins to the basal RNA polymerase II
CC transcription machinery. Mediator is recruited to promoters by direct
CC interactions with regulatory proteins and serves as a scaffold for the
CC assembly of a functional preinitiation complex with RNA polymerase II
CC and the general transcription factors. {ECO:0000256|RuleBase:RU364059}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU364059}.
CC -!- SIMILARITY: Belongs to the Mediator complex subunit 1 family.
CC {ECO:0000256|ARBA:ARBA00006210, ECO:0000256|RuleBase:RU364059}.
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DR EMBL; GL573209; ELR07950.1; -; Genomic_DNA.
DR RefSeq; XP_012741217.1; XM_012885763.1.
DR AlphaFoldDB; L8G3U6; -.
DR STRING; 658429.L8G3U6; -.
DR VEuPathDB; FungiDB:GMDG_02809; -.
DR HOGENOM; CLU_008378_1_0_1; -.
DR InParanoid; L8G3U6; -.
DR OrthoDB; 2102567at2759; -.
DR Proteomes; UP000011064; Unassembled WGS sequence.
DR GO; GO:0016592; C:mediator complex; IEA:InterPro.
DR GO; GO:0003712; F:transcription coregulator activity; IEA:InterPro.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:UniProt.
DR InterPro; IPR019680; Mediator_Med1.
DR PANTHER; PTHR35041; MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 1; 1.
DR PANTHER; PTHR35041:SF4; MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 1; 1.
DR Pfam; PF10744; Med1; 1.
PE 3: Inferred from homology;
KW Activator {ECO:0000256|ARBA:ARBA00023159, ECO:0000256|RuleBase:RU364059};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU364059};
KW Reference proteome {ECO:0000313|Proteomes:UP000011064};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU364059};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU364059}.
FT DOMAIN 126..543
FT /note="Mediator complex subunit Med1"
FT /evidence="ECO:0000259|Pfam:PF10744"
FT REGION 1..50
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 20..50
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 674 AA; 73130 MW; 385FAC6C9703B8EF CRC64;
MATPTPVGKH PASLRAGLTP PVSTPFSASK SVNLSPQQYK KSPANSNQYA HPTASSFGGI
NFDSPTTAAA LATLPLGDLG LDASAGGLGG GLGHLGGGLG LGTGLGGLQG IGRLDEDERK
RRKLMQIVDT LKAVKGRVSE DGIERLARSV GLECLWETGM GRGGKSKTLI IAGTGLSIDI
EFTDNVVETV TLGFPESPES VTRHADQAGR ILLDDLKLSK DETVLTKRVD RFAGNLDRMA
RLDKLSVMPQ LNCHEAVAGI YDSLERLHKW EVARLTEEEA MSGKTQEQIV RAALLQKSGR
PAMNAHGNVG LCLEYWQERH ATSQGEGCKT WSLLLECDQS SSMVYPPVRV SSAWISPSVA
KSNPTADDVL LSASDVVLDW QDPPNILLTS NPDQKDDSGM EGIEQPGQLP NQKFPDVRFV
AKFSPPLTLP YSAAMQIYDS TSAHLEPDAL AALDALAFPP QTAETSEPDG AHRRIRKEQL
VSVYNRAGEH EKKCHTNTLT IPKMEYALTL TEVPFSHPRE LVQMLPILRQ YTRLSTLLER
SFGSKYTSDH KTESEDVPGE ESTVKDEFDA FMAEASHKDK DLQFTKIPVD VSLYTQPGPS
LRIIFPLGPR IADILVGIES NGSLSVVSQN ILPDGDGMTE TTKMKSLVVD DLGRILETCE
DIGIFAEFLR QRLV
//
