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Database: UniProt
Entry: L8GB43_PSED2
LinkDB: L8GB43_PSED2
Original site: L8GB43_PSED2 
ID   L8GB43_PSED2            Unreviewed;       870 AA.
AC   L8GB43;
DT   03-APR-2013, integrated into UniProtKB/TrEMBL.
DT   03-APR-2013, sequence version 1.
DT   07-JUN-2017, entry version 13.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN   ORFNames=GMDG_04353 {ECO:0000313|EMBL:ELR09873.1};
OS   Pseudogymnoascus destructans (strain ATCC MYA-4855 / 20631-21) (Bat
OS   white-nose syndrome fungus) (Geomyces destructans).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC   Leotiomycetes incertae sedis; Pseudeurotiaceae; Pseudogymnoascus.
OX   NCBI_TaxID=658429 {ECO:0000313|EMBL:ELR09873.1, ECO:0000313|Proteomes:UP000011064};
RN   [1] {ECO:0000313|Proteomes:UP000011064}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC MYA-4855 / 20631-21 {ECO:0000313|Proteomes:UP000011064};
RG   The Broad Institute Genome Sequencing Platform;
RA   Cuomo C.A., Blehert D.S., Lorch J.M., Young S.K., Zeng Q., Gargeya S.,
RA   Fitzgerald M., Haas B., Abouelleil A., Alvarado L., Arachchi H.M.,
RA   Berlin A., Brown A., Chapman S.B., Chen Z., Dunbar C., Freedman E.,
RA   Gearin G., Gellesch M., Goldberg J., Griggs A., Gujja S., Heiman D.,
RA   Howarth C., Larson L., Lui A., MacDonald P.J.P., Montmayeur A.,
RA   Murphy C., Neiman D., Pearson M., Priest M., Roberts A., Saif S.,
RA   Shea T., Shenoy N., Sisk P., Stolte C., Sykes S., Wortman J.,
RA   Nusbaum C., Birren B.;
RT   "The genome sequence of Geomyces destructans 20631-21.";
RL   Submitted (SEP-2010) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-
CC       ATPase), a multimeric enzyme that catalyzes the translocation of
CC       protons across the membranes. Required for assembly and activity
CC       of the V-ATPase. {ECO:0000256|RuleBase:RU361189}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|RuleBase:RU361189}.
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DR   EMBL; GL573245; ELR09873.1; -; Genomic_DNA.
DR   RefSeq; XP_012742773.1; XM_012887319.1.
DR   EnsemblFungi; ELR09873; ELR09873; GMDG_04353.
DR   GeneID; 24485232; -.
DR   InParanoid; L8GB43; -.
DR   OrthoDB; EOG092C0YCY; -.
DR   Proteomes; UP000011064; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0015078; F:hydrogen ion transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629; PTHR11629; 1.
DR   Pfam; PF01496; V_ATPase_I; 1.
DR   PIRSF; PIRSF001293; ATP6V0A1; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000011064};
KW   Hydrogen ion transport {ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|RuleBase:RU361189};
KW   Reference proteome {ECO:0000313|Proteomes:UP000011064};
KW   Transmembrane {ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    424    449       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    469    488       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    548    566       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    578    601       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    657    676       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    770    789       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    801    822       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   COILED      101    128       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   870 AA;  99592 MW;  000D72BA9354D7AF CRC64;
     MAPAKDTMFR SVDMSMVQLY VANEIGREVI NALGEIGQIQ FRDLNSETSA FQRTFTQEIR
     RLDNVERQLR YFHSQMEKAE IPLRKLDLDI ESLAAPSTSE IDELSDRSQS LEQRVASLND
     SYETLKKREV ELIEWRWVLK EAGGFFDRAH GNVDELRTSI DQDDDAPLLQ DVEQHPQNGE
     AGERSLSIMN IGFVSGVIPR ERVAAFERIL WRTLRGNLYM NQSEIPETLV DPTNNERVDK
     NVFVIFAHGK EIIAKIRKIS ESLGADLYNV DENSDLRRDQ IHEVNTRLSD LGSVLRNTKQ
     TLDAELTQIA RSLAAWIVII KKEKAVYETL NLLSFDHARK TLIAEAWCPS NSLPQIKAAL
     QDVNNRAGLT VPSIINEIRT NKTPPTLQKT NRFTEGFQTI INAYGTSKYH EVNPGLPTIV
     TFPFLFAVMF GDLGHGFIMF CAAAAMIYWE KPLKKVRDEL FTMAYYGRYI MLMMGIFSMY
     TGLIYNDIFS RSMSLFSSAW EWPTDFKKGD TVVAHLNRDG HRYPFGLDWM WHGAENELLF
     ANSYKMKLSI LMGWCHMTYS LCLSYINARR FKSPIDIWGN FIPGMIFFQS IFGYLVFTIV
     YKWSTDWYPL APDDWPAGVQ APNHRNPPGL LNMLIYMFLQ PGTIDVPLYG DGTYQKIIQN
     FLVVIAIIQV PILLFLKPFY LRWENNQARA KGYRGIGETS RISALDGDDD DRRASIASET
     EGVDMITQGI DNDAEGHEEF EFGEVMIHQV IHTIEFCLNC VSHTASYLRL WALSLAHQQL
     SLVLWSMTLN NGLNSTGISG VITLVVTFYM WFFLSVCVLV VMEGTSAMLH SLRLHWVEAM
     SKHFMGDGIA FEPFSFRQML EEDEEVKEFS
//
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