ID L8GCG2_PSED2 Unreviewed; 1002 AA.
AC L8GCG2;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 1.
DT 22-FEB-2023, entry version 53.
DE RecName: Full=DH domain-containing protein {ECO:0000259|PROSITE:PS50010};
GN ORFNames=GMDG_05012 {ECO:0000313|EMBL:ELR10757.1};
OS Pseudogymnoascus destructans (strain ATCC MYA-4855 / 20631-21) (Bat
OS white-nose syndrome fungus) (Geomyces destructans).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Leotiomycetes incertae sedis; Pseudeurotiaceae; Pseudogymnoascus.
OX NCBI_TaxID=658429 {ECO:0000313|EMBL:ELR10757.1, ECO:0000313|Proteomes:UP000011064};
RN [1] {ECO:0000313|Proteomes:UP000011064}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4855 / 20631-21 {ECO:0000313|Proteomes:UP000011064};
RG The Broad Institute Genome Sequencing Platform;
RA Cuomo C.A., Blehert D.S., Lorch J.M., Young S.K., Zeng Q., Gargeya S.,
RA Fitzgerald M., Haas B., Abouelleil A., Alvarado L., Arachchi H.M.,
RA Berlin A., Brown A., Chapman S.B., Chen Z., Dunbar C., Freedman E.,
RA Gearin G., Gellesch M., Goldberg J., Griggs A., Gujja S., Heiman D.,
RA Howarth C., Larson L., Lui A., MacDonald P.J.P., Montmayeur A., Murphy C.,
RA Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T., Shenoy N.,
RA Sisk P., Stolte C., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT "The genome sequence of Geomyces destructans 20631-21.";
RL Submitted (SEP-2010) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; GL573267; ELR10757.1; -; Genomic_DNA.
DR RefSeq; XP_012743439.1; XM_012887985.1.
DR AlphaFoldDB; L8GCG2; -.
DR STRING; 658429.L8GCG2; -.
DR VEuPathDB; FungiDB:GMDG_05012; -.
DR HOGENOM; CLU_007879_1_0_1; -.
DR InParanoid; L8GCG2; -.
DR OrthoDB; 23973at2759; -.
DR Proteomes; UP000011064; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd05992; PB1; 1.
DR CDD; cd13246; PH_Scd1; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR010481; Cdc24/Scd1_N.
DR InterPro; IPR033511; Cdc24/Scd1_PH_dom.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR001331; GDS_CDC24_CS.
DR InterPro; IPR000270; PB1_dom.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR47339; CELL DIVISION CONTROL PROTEIN 24; 1.
DR PANTHER; PTHR47339:SF1; CELL DIVISION CONTROL PROTEIN 24; 1.
DR Pfam; PF06395; CDC24; 1.
DR Pfam; PF00564; PB1; 1.
DR Pfam; PF15411; PH_10; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF54277; CAD & PB1 domains; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS00741; DH_1; 1.
DR PROSITE; PS50010; DH_2; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000011064}.
FT DOMAIN 245..420
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT REGION 1..56
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 626..897
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 20..35
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 634..660
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 677..695
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 703..733
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 743..799
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 821..854
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 869..893
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1002 AA; 111225 MW; A0C888CE54B057D3 CRC64;
MSSGTITMAM AHGPGLTRIH TAPTPSTSTR TSRDPFPSKM IGHGPRSSKM SSSTLTSASS
ASLNTLSTTT TISQNGSNVV ATNNIINQRA DASRSLYQIC VSLRQRLLLV PGFEQHLQEL
DDDEIYDDDP VTSLWRCLRK GYPLMTIYNA LQPPEPLQVD DKVSDAKKPK SAASKFVLAC
LKDLKLPPEE VFVLNDLLGD DTTGFVKVTQ VLNVVLDVAG QRGLLLTAEA EAETPNAAVG
GKMSYRDHVV RELVDTERKY VQDLENLHEL KKQIEQKGVI PGDVVHAIFL NINAILDFQR
RFLIRIETTN SQPDARQEWG APFVFHEESF GIYQPFIANQ RRAADIAKRE FDKISLADHP
VVVDFNTLDG FLLKPMQRLV KYPLLLKDLR DKTNADDQTK AELTAGMEAS NRVLHQANAA
VDRELRNEAL VDLCTRVDDW KNHDINQFGD LLLHGVFTVI TGKSDLEKEY TIYLFERILL
CCKEVKDKLM GGGQKDKKAA KDKKDKSGKT IKLQLKGRIF MTNVTDVVSM VKPGSYTVQI
WWKGDPGIEN FMIRFSHEEV MKKWSAAVDK QRKDCLDREQ GGAEVGTPEF AWMQVQKGPI
DNPYAQPEDD DDDEYPQLAN SGVFAEQAVP PEQNTFAMDR NTSSTSLRSR STTGESIQSI
AGAVRQAPPR FPMGPQPPLS LQTQMPLQTP PGTRGGDSYF SPVAESPASS RTSQNSMFPF
PRQGSQTGNW EDHNRYTAPA IGRTPSRESQ QSINYRNNPQ RPSLPVMSSQ QAQMVNAQNR
SRSYSTPDIN AQVNAARRRN DSQPVPAVPG IPPHLHPAYD NSIPRSSNGS PINGIPVRSA
TQSPGTQRDG SQPPQASYPA VPPAYLRSNT TPVLATVKGG EDRTQTMSPP LSNALPEMNM
PLPTQLKVKV NCDGNYVTLV VAFNITYRSL IDRIDAKVGR FSNNAIARGT MRLRYQDEDG
DYVTIESDDD IHIAFQEWRE QQIEGLKNGM LGEIELFCAS IE
//
