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Database: UniProt
Entry: L8GM39_ACACA
LinkDB: L8GM39_ACACA
Original site: L8GM39_ACACA 
ID   L8GM39_ACACA            Unreviewed;       372 AA.
AC   L8GM39;
DT   03-APR-2013, integrated into UniProtKB/TrEMBL.
DT   03-APR-2013, sequence version 1.
DT   22-NOV-2017, entry version 18.
DE   SubName: Full=Aspartyl aminopeptidase {ECO:0000313|EMBL:ELR14057.1};
GN   ORFNames=ACA1_366690 {ECO:0000313|EMBL:ELR14057.1};
OS   Acanthamoeba castellanii str. Neff.
OC   Eukaryota; Amoebozoa; Discosea; Longamoebia; Centramoebida;
OC   Acanthamoebidae; Acanthamoeba.
OX   NCBI_TaxID=1257118 {ECO:0000313|EMBL:ELR14057.1, ECO:0000313|Proteomes:UP000011083};
RN   [1] {ECO:0000313|EMBL:ELR14057.1, ECO:0000313|Proteomes:UP000011083}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Neff {ECO:0000313|EMBL:ELR14057.1,
RC   ECO:0000313|Proteomes:UP000011083};
RX   PubMed=23375108; DOI=10.1186/gb-2013-14-2-r11;
RA   Clarke M., Lohan A.J., Liu B., Lagkouvardos I., Roy S., Zafar N.,
RA   Bertelli C., Schilde C., Kianianmomeni A., Burglin T.R., Frech C.,
RA   Turcotte B., Kopec K.O., Synnott J.M., Choo C., Paponov I.,
RA   Finkler A., Soon Heng Tan C., Hutchins A.P., Weinmeier T., Rattei T.,
RA   Chu J.S., Gimenez G., Irimia M., Rigden D.J., Fitzpatrick D.A.,
RA   Lorenzo-Morales J., Bateman A., Chiu C.H., Tang P., Hegemann P.,
RA   Fromm H., Raoult D., Greub G., Miranda-Saavedra D., Chen N., Nash P.,
RA   Ginger M.L., Horn M., Schaap P., Caler L., Loftus B.;
RT   "Genome of Acanthamoeba castellanii highlights extensive lateral gene
RT   transfer and early evolution of tyrosine kinase signaling.";
RL   Genome Biol. 14:R11-R11(2013).
CC   -!- SIMILARITY: Belongs to the peptidase M18 family.
CC       {ECO:0000256|RuleBase:RU004386}.
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DR   EMBL; KB008073; ELR14057.1; -; Genomic_DNA.
DR   RefSeq; XP_004336070.1; XM_004336022.1.
DR   MEROPS; M18.A01; -.
DR   EnsemblProtists; ELR14057; ELR14057; ACA1_366690.
DR   GeneID; 14914560; -.
DR   KEGG; acan:ACA1_366690; -.
DR   EuPathDB; AmoebaDB:ACA1_366690; -.
DR   KO; K01267; -.
DR   Proteomes; UP000011083; Unassembled WGS sequence.
DR   GO; GO:0004177; F:aminopeptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0008237; F:metallopeptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   InterPro; IPR001948; Peptidase_M18.
DR   InterPro; IPR023367; Peptidase_M42_dom2.
DR   PANTHER; PTHR28570; PTHR28570; 1.
DR   Pfam; PF02127; Peptidase_M18; 1.
DR   PRINTS; PR00932; AMINO1PTASE.
DR   SUPFAM; SSF101821; SSF101821; 1.
PE   3: Inferred from homology;
KW   Aminopeptidase {ECO:0000256|RuleBase:RU004386,
KW   ECO:0000313|EMBL:ELR14057.1};
KW   Complete proteome {ECO:0000313|Proteomes:UP000011083};
KW   Hydrolase {ECO:0000256|RuleBase:RU004386};
KW   Metal-binding {ECO:0000256|RuleBase:RU004386};
KW   Metalloprotease {ECO:0000256|RuleBase:RU004386};
KW   Protease {ECO:0000256|RuleBase:RU004386};
KW   Reference proteome {ECO:0000313|Proteomes:UP000011083};
KW   Zinc {ECO:0000256|RuleBase:RU004386}.
SQ   SEQUENCE   372 AA;  40797 MW;  7C3E8A6A93DF97AE CRC64;
     MQIKPVSIRE SKGFLQVGVE TYGGGLWHTW FDRDLTVAGR VVVATGENKF EHRLVRLTRP
     ILRVPNLAIH LTSGDERTAF KVNTQTHLGF PVLATSIKNT LNKPTDAKPS HQPLLLKLLA
     DELGVEASQI RDLELSVCDT QPACVGGALN EFIFSPRLDN LMMSYCCLTG FLAASTPESV
     ANDTRIRLVA LFDNEEIGSE SAHGAASNLM PQTIERILAC AGLGNSVDAV QRAYRQSYLI
     SADMAHAVHP NYPEKHEENH QPMMQKGVAI KYNANQRYAT TSITAFLLKE LARRHGVPMQ
     EFVVRNDSPC GSTIGPILSA GCGIRTIDIG LPQLSMHSIR EMCGADDVSH AVNLLKAFYS
     DFSKLDESLV VD
//
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