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Database: UniProt
Entry: L8HHZ1_ACACA
LinkDB: L8HHZ1_ACACA
Original site: L8HHZ1_ACACA 
ID   L8HHZ1_ACACA            Unreviewed;       801 AA.
AC   L8HHZ1;
DT   03-APR-2013, integrated into UniProtKB/TrEMBL.
DT   03-APR-2013, sequence version 1.
DT   05-JUL-2017, entry version 19.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN   ORFNames=ACA1_175060 {ECO:0000313|EMBL:ELR24832.1};
OS   Acanthamoeba castellanii str. Neff.
OC   Eukaryota; Amoebozoa; Discosea; Longamoebia; Centramoebida;
OC   Acanthamoebidae; Acanthamoeba.
OX   NCBI_TaxID=1257118 {ECO:0000313|EMBL:ELR24832.1, ECO:0000313|Proteomes:UP000011083};
RN   [1] {ECO:0000313|EMBL:ELR24832.1, ECO:0000313|Proteomes:UP000011083}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Neff {ECO:0000313|EMBL:ELR24832.1,
RC   ECO:0000313|Proteomes:UP000011083};
RX   PubMed=23375108; DOI=10.1186/gb-2013-14-2-r11;
RA   Clarke M., Lohan A.J., Liu B., Lagkouvardos I., Roy S., Zafar N.,
RA   Bertelli C., Schilde C., Kianianmomeni A., Burglin T.R., Frech C.,
RA   Turcotte B., Kopec K.O., Synnott J.M., Choo C., Paponov I.,
RA   Finkler A., Soon Heng Tan C., Hutchins A.P., Weinmeier T., Rattei T.,
RA   Chu J.S., Gimenez G., Irimia M., Rigden D.J., Fitzpatrick D.A.,
RA   Lorenzo-Morales J., Bateman A., Chiu C.H., Tang P., Hegemann P.,
RA   Fromm H., Raoult D., Greub G., Miranda-Saavedra D., Chen N., Nash P.,
RA   Ginger M.L., Horn M., Schaap P., Caler L., Loftus B.;
RT   "Genome of Acanthamoeba castellanii highlights extensive lateral gene
RT   transfer and early evolution of tyrosine kinase signaling.";
RL   Genome Biol. 14:R11-R11(2013).
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-
CC       ATPase), a multimeric enzyme that catalyzes the translocation of
CC       protons across the membranes. Required for assembly and activity
CC       of the V-ATPase. {ECO:0000256|RuleBase:RU361189}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|RuleBase:RU361189}.
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DR   EMBL; KB007811; ELR24832.1; -; Genomic_DNA.
DR   RefSeq; XP_004356732.1; XM_004356679.1.
DR   EnsemblProtists; ELR24832; ELR24832; ACA1_175060.
DR   GeneID; 14925863; -.
DR   KEGG; acan:ACA1_175060; -.
DR   EuPathDB; AmoebaDB:ACA1_175060; -.
DR   KO; K02154; -.
DR   Proteomes; UP000011083; Unassembled WGS sequence.
DR   GO; GO:0031164; C:contractile vacuolar membrane; IEA:EnsemblProtists.
DR   GO; GO:0010008; C:endosome membrane; IEA:EnsemblProtists.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005764; C:lysosome; IEA:EnsemblProtists.
DR   GO; GO:0030670; C:phagocytic vesicle membrane; IEA:EnsemblProtists.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0015078; F:hydrogen ion transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
DR   GO; GO:0006911; P:phagocytosis, engulfment; IEA:EnsemblProtists.
DR   GO; GO:0051453; P:regulation of intracellular pH; IEA:EnsemblProtists.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629; PTHR11629; 1.
DR   Pfam; PF01496; V_ATPase_I; 1.
DR   PIRSF; PIRSF001293; ATP6V0A1; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000011083};
KW   Hydrogen ion transport {ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|RuleBase:RU361189};
KW   Reference proteome {ECO:0000313|Proteomes:UP000011083};
KW   Transmembrane {ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    412    436       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    457    474       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    532    553       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    565    585       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    626    650       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    733    755       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   COILED       95    143       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   801 AA;  92623 MW;  2D0EE4E29DE154E5 CRC64;
     MGELFRSEPM QLVQLFMSLE AARDTVDELG EIGLIQFKDL NPEVNAIQRN FVAEVKRCDE
     MERKLRFFED QIEKQNFAEE ELEHLQLGLS IGSSKKTLVP EMDELEARFE DLEKELTQMN
     SNQEKLKRNY NELIELKHVL EKDSVFFESS GGAERDRYDE EADVGSSEVA GLTSFGVKLG
     FVTGVVERSK MVTFERVLWR ATRGNLFMRT APIEERIEDP KTNELVDKLV FIIFFQGDRA
     ESKVKKICES FGANLYPCPD SAQERREMFN QVETRLDDLD VVLERSLDHR KKVLLDIATH
     IEDWKTQVVK EKSIYHNMNL FNYDVGRKCL IAEGWCPLTA TEDIQDALKR ANERSGTLVP
     SIVNVVKTRE QPPTHFKTNK FTKSFQGIVD AYGMARYREV NPGVFTIVTF PFLFGMMFGD
     VGHGIMLFIF AVYLCIKEDT FSKMKLNEMV KTCFDGRYLL LLMALGAIYC GALYNEVFSV
     PLDIFGSRWQ YFEGEQFAEW TNPGIAYPFG VDPAWKGAKN ELLYYNSIKM KLSIIFGVTH
     MVFGILLSAL NGIYFKKPYN IWFEFVPQLC FMMSIFGYMV FLIFFKWSYE FSAPQDAPNL
     LNLMISMFLK PFKLQPIDDL FPGQLYLQWV LIAVCAISVP MMLLPKPLLL RRDHKRGYKR
     LAESHEEDGD EEEEEFDFNE IFIHQIIHTI EFVLGAISNT ASYLRLWALS LAHSELATVF
     WERVLVLTLE KNNFFLIFVG FAIWAGATFG VLLVMESLSA FLHALRLHWV EFQNKFYMGD
     GYKFQPFSYQ QILSGEEEGG L
//
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