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Database: UniProt
Entry: L8HPW7_9CETA
LinkDB: L8HPW7_9CETA
Original site: L8HPW7_9CETA 
ID   L8HPW7_9CETA            Unreviewed;       915 AA.
AC   L8HPW7;
DT   03-APR-2013, integrated into UniProtKB/TrEMBL.
DT   03-APR-2013, sequence version 1.
DT   24-JAN-2024, entry version 46.
DE   RecName: Full=dolichyl-phosphate-mannose--protein mannosyltransferase {ECO:0000256|ARBA:ARBA00012839};
DE            EC=2.4.1.109 {ECO:0000256|ARBA:ARBA00012839};
GN   ORFNames=M91_06625 {ECO:0000313|EMBL:ELR45097.1};
OS   Bos mutus (wild yak).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=72004 {ECO:0000313|EMBL:ELR45097.1, ECO:0000313|Proteomes:UP000011080};
RN   [1] {ECO:0000313|EMBL:ELR45097.1, ECO:0000313|Proteomes:UP000011080}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=yakQH1 {ECO:0000313|Proteomes:UP000011080};
RX   PubMed=22751099; DOI=10.1038/ng.2343;
RA   Qiu Q., Zhang G., Ma T., Qian W., Wang J., Ye Z., Cao C., Hu Q., Kim J.,
RA   Larkin D.M., Auvil L., Capitanu B., Ma J., Lewin H.A., Qian X., Lang Y.,
RA   Zhou R., Wang L., Wang K., Xia J., Liao S., Pan S., Lu X., Hou H., Wang Y.,
RA   Zang X., Yin Y., Ma H., Zhang J., Wang Z., Zhang Y., Zhang D., Yonezawa T.,
RA   Hasegawa M., Zhong Y., Liu W., Zhang Y., Huang Z., Zhang S., Long R.,
RA   Yang H., Wang J., Lenstra J.A., Cooper D.N., Wu Y., Wang J., Shi P.,
RA   Wang J., Liu J.;
RT   "The yak genome and adaptation to life at high altitude.";
RL   Nat. Genet. 44:946-949(2012).
CC   -!- PATHWAY: Protein modification; protein glycosylation.
CC       {ECO:0000256|ARBA:ARBA00004922}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum
CC       {ECO:0000256|ARBA:ARBA00004240}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the TMTC family.
CC       {ECO:0000256|ARBA:ARBA00007882}.
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DR   EMBL; JH884552; ELR45097.1; -; Genomic_DNA.
DR   AlphaFoldDB; L8HPW7; -.
DR   STRING; 72004.ENSBMUP00000031095; -.
DR   Ensembl; ENSBMUT00000035776; ENSBMUP00000031095; ENSBMUG00000023209.
DR   UniPathway; UPA00378; -.
DR   Proteomes; UP000011080; Unassembled WGS sequence.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004169; F:dolichyl-phosphate-mannose-protein mannosyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:1901800; P:positive regulation of proteasomal protein catabolic process; IEA:Ensembl.
DR   GO; GO:0034976; P:response to endoplasmic reticulum stress; IEA:Ensembl.
DR   Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 4.
DR   InterPro; IPR013618; TMTC_DUF1736.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR001440; TPR_1.
DR   InterPro; IPR019734; TPR_repeat.
DR   PANTHER; PTHR44395; -; 1.
DR   PANTHER; PTHR44395:SF1; PROTEIN O-MANNOSYL-TRANSFERASE TMTC3; 1.
DR   Pfam; PF08409; TMTC_DUF1736; 1.
DR   Pfam; PF00515; TPR_1; 1.
DR   Pfam; PF13174; TPR_6; 1.
DR   Pfam; PF13181; TPR_8; 6.
DR   SMART; SM00028; TPR; 9.
DR   SUPFAM; SSF48452; TPR-like; 2.
DR   PROSITE; PS50005; TPR; 3.
DR   PROSITE; PS50293; TPR_REGION; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000011080};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   TPR repeat {ECO:0000256|ARBA:ARBA00022803, ECO:0000256|PROSITE-
KW   ProRule:PRU00339};
KW   Transmembrane {ECO:0000256|SAM:Phobius, ECO:0000313|EMBL:ELR45097.1};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        9..30
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        90..108
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        136..157
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        169..186
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        192..215
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        236..256
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        321..340
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        347..371
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        377..393
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          259..330
FT                   /note="DUF1736"
FT                   /evidence="ECO:0000259|Pfam:PF08409"
FT   REPEAT          446..479
FT                   /note="TPR"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT   REPEAT          563..596
FT                   /note="TPR"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT   REPEAT          597..630
FT                   /note="TPR"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT   REGION          847..889
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        856..874
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        875..889
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   915 AA;  103858 MW;  07991110D8B77E1F CRC64;
     MADINLKEVT LIVGVVAVCY WNSLFCGFVF DDVSAILDNK DLHPSTPLKT LFQNDFWGTP
     MSEERSHKSY RPLTVLTFRL NYLFSELTPM SYHLLNMIFH AVVSVIFLKV CRLFLNNQSS
     MIASLLFAVH PIHTEAVTGV VGRAELLSSI FFLAAFLSYT KSKGPDNSIV WTPIALTVFL
     VAVATLCKEQ GITVVGICCV YEVFIAQGYT LPLLCTTAGQ FLRGKGSIPF SMLQTLIKLI
     VLMFSTLLLV VIRVQVIQSQ LPVFTRFDNP AAVSPTPTRQ LTFNYLLPVN AWLLLNPSEL
     CCDWTMGTIP LIESFLDVRN LATFIFFCFL GALGVFSLRY PSNSSKTVLM ALCLMALPFI
     PASNLFFPVG FVVAERVLYV PSMGFCILVA HGWQKISNKS VFKKLSWVCL SLVIFTHALK
     TLHRNWDWES EYTLFMSALK VNKNNAKLWN NVGHALENEK NFERALKYFL QATHVQPDDI
     GAHMNVGRTY KNLNRTKEAE ESYMTAKSLM PQIIPGKKYA ARIAPNHLNV YINLANLIRA
     NESRLEEADQ LYRQAISMRP DFKQAYISRG ELLLKMNKPA KAKEAYLKAL ELDRNNADLW
     YNLAIVHIEL KEPNDALKNF NHALELNPKH KLALFNSAIL MQESGEVRLR PEARKRLLSY
     INEEPQDANG YFNLGMLAMD DKKDSEAEMW MKKAIKLQAD FRSALFNLAL LYSQTAKELM
     ALPVLEELLK YYPDHIKGLI LKGDILMNQK KDIRGAKKCF EKILEMDPSN VQGKHNLCVV
     YFEEKDLLKA ERCLVETLAL APHEEYIQRH LNIVRDKISS SSFVEQPIFP AGKTSGVEGD
     KIPTENVKEI KSEPRPTQII KTNDNKSQSK ASKQLGKNTD KEIPHKTTKE IKEIEKKRVA
     ALKRLEEIER ILNGE
//
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