ID L8HQX6_9CETA Unreviewed; 228 AA.
AC L8HQX6;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE RecName: Full=Mitochondrial glutathione transporter SLC25A39 {ECO:0000256|RuleBase:RU369018};
DE AltName: Full=Solute carrier family 25 member 39 {ECO:0000256|RuleBase:RU369018};
DE Flags: Fragment;
GN ORFNames=M91_15034 {ECO:0000313|EMBL:ELR45447.1};
OS Bos mutus (wild yak).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=72004 {ECO:0000313|EMBL:ELR45447.1, ECO:0000313|Proteomes:UP000011080};
RN [1] {ECO:0000313|EMBL:ELR45447.1, ECO:0000313|Proteomes:UP000011080}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=yakQH1 {ECO:0000313|Proteomes:UP000011080};
RX PubMed=22751099; DOI=10.1038/ng.2343;
RA Qiu Q., Zhang G., Ma T., Qian W., Wang J., Ye Z., Cao C., Hu Q., Kim J.,
RA Larkin D.M., Auvil L., Capitanu B., Ma J., Lewin H.A., Qian X., Lang Y.,
RA Zhou R., Wang L., Wang K., Xia J., Liao S., Pan S., Lu X., Hou H., Wang Y.,
RA Zang X., Yin Y., Ma H., Zhang J., Wang Z., Zhang Y., Zhang D., Yonezawa T.,
RA Hasegawa M., Zhong Y., Liu W., Zhang Y., Huang Z., Zhang S., Long R.,
RA Yang H., Wang J., Lenstra J.A., Cooper D.N., Wu Y., Wang J., Shi P.,
RA Wang J., Liu J.;
RT "The yak genome and adaptation to life at high altitude.";
RL Nat. Genet. 44:946-949(2012).
CC -!- FUNCTION: Mitochondrial transporter required for glutathione import
CC into mitochondria. Glutathione, which plays key roles in oxidative
CC metabolism, is produced exclusively in the cytosol and is imported in
CC many organelles. Mitochondrial glutathione is required for the activity
CC and stability of proteins containing iron-sulfur clusters, as well as
CC erythropoiesis. {ECO:0000256|RuleBase:RU369018}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. Mitochondrion
CC inner membrane {ECO:0000256|ARBA:ARBA00004448,
CC ECO:0000256|RuleBase:RU369018}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004448, ECO:0000256|RuleBase:RU369018}.
CC -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family.
CC {ECO:0000256|ARBA:ARBA00006375, ECO:0000256|RuleBase:RU000488}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU369018}.
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DR EMBL; JH884163; ELR45447.1; -; Genomic_DNA.
DR AlphaFoldDB; L8HQX6; -.
DR Proteomes; UP000011080; Unassembled WGS sequence.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:1990542; P:mitochondrial transmembrane transport; IEA:InterPro.
DR Gene3D; 1.50.40.10; Mitochondrial carrier domain; 1.
DR InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR InterPro; IPR023395; Mt_carrier_dom_sf.
DR InterPro; IPR045315; Mtm1-like.
DR PANTHER; PTHR45760; FI19922P1-RELATED; 1.
DR PANTHER; PTHR45760:SF5; MITOCHONDRIAL GLUTATHIONE TRANSPORTER SLC25A40-RELATED; 1.
DR Pfam; PF00153; Mito_carr; 2.
DR SUPFAM; SSF103506; Mitochondrial carrier; 1.
DR PROSITE; PS50920; SOLCAR; 2.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PROSITE-
KW ProRule:PRU00282}; Mitochondrion {ECO:0000256|RuleBase:RU369018};
KW Mitochondrion inner membrane {ECO:0000256|RuleBase:RU369018};
KW Reference proteome {ECO:0000313|Proteomes:UP000011080};
KW Repeat {ECO:0000256|RuleBase:RU369018};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|PROSITE-
KW ProRule:PRU00282}; Transmembrane helix {ECO:0000256|RuleBase:RU369018};
KW Transport {ECO:0000256|RuleBase:RU000488}.
FT TRANSMEM 32..54
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU369018"
FT TRANSMEM 127..148
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU369018"
FT REPEAT 28..112
FT /note="Solcar"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00282"
FT REPEAT 125..219
FT /note="Solcar"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00282"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ELR45447.1"
SQ SEQUENCE 228 AA; 25899 MW; 5226C54B032A22C7 CRC64;
VMAVPATVIY FTCYDQLTAL LRSKLGENES RIPIVAGIVA RLGAVTVISP LELIRTKMQS
KKFSYEELHR FVSKKVSEDG WISLWRGWAP TILRDVPFSV CCWVCTRICS FKCLFKKICL
KMFSRSFSLN ISGFTLCFKF AAVVTLPFDV VKTQKQTQLW IYESQKISMP LQMSTWTIMK
NTVAKNGFSG LFTGLIPRLI KIAPACAVMI STYEFGKSVF QKQNAQRQ
//
