ID L8HT31_9CETA Unreviewed; 318 AA.
AC L8HT31;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 1.
DT 27-MAR-2024, entry version 48.
DE RecName: Full=Mitochondrial thiamine pyrophosphate carrier {ECO:0000256|ARBA:ARBA00040836};
DE AltName: Full=Solute carrier family 25 member 19 {ECO:0000256|ARBA:ARBA00041879};
GN ORFNames=M91_03322 {ECO:0000313|EMBL:ELR47450.1};
OS Bos mutus (wild yak).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=72004 {ECO:0000313|EMBL:ELR47450.1, ECO:0000313|Proteomes:UP000011080};
RN [1] {ECO:0000313|EMBL:ELR47450.1, ECO:0000313|Proteomes:UP000011080}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=yakQH1 {ECO:0000313|Proteomes:UP000011080};
RX PubMed=22751099; DOI=10.1038/ng.2343;
RA Qiu Q., Zhang G., Ma T., Qian W., Wang J., Ye Z., Cao C., Hu Q., Kim J.,
RA Larkin D.M., Auvil L., Capitanu B., Ma J., Lewin H.A., Qian X., Lang Y.,
RA Zhou R., Wang L., Wang K., Xia J., Liao S., Pan S., Lu X., Hou H., Wang Y.,
RA Zang X., Yin Y., Ma H., Zhang J., Wang Z., Zhang Y., Zhang D., Yonezawa T.,
RA Hasegawa M., Zhong Y., Liu W., Zhang Y., Huang Z., Zhang S., Long R.,
RA Yang H., Wang J., Lenstra J.A., Cooper D.N., Wu Y., Wang J., Shi P.,
RA Wang J., Liu J.;
RT "The yak genome and adaptation to life at high altitude.";
RL Nat. Genet. 44:946-949(2012).
CC -!- FUNCTION: Mitochondrial transporter mediating uptake of thiamine
CC diphosphate into mitochondria. It is not clear if the antiporter
CC activity is affected by the membrane potential or by the proton
CC electrochemical gradient. {ECO:0000256|ARBA:ARBA00037549}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=thiamine diphosphate(in) + thiamine phosphate(out) = thiamine
CC diphosphate(out) + thiamine phosphate(in); Xref=Rhea:RHEA:73383,
CC ChEBI:CHEBI:37575, ChEBI:CHEBI:58937;
CC Evidence={ECO:0000256|ARBA:ARBA00035968};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family.
CC {ECO:0000256|ARBA:ARBA00006375, ECO:0000256|RuleBase:RU000488}.
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DR EMBL; JH883080; ELR47450.1; -; Genomic_DNA.
DR RefSeq; XP_005908005.1; XM_005907943.2.
DR RefSeq; XP_014337746.1; XM_014482260.1.
DR AlphaFoldDB; L8HT31; -.
DR STRING; 72004.ENSBMUP00000011355; -.
DR Ensembl; ENSBMUT00000013189; ENSBMUP00000011355; ENSBMUG00000008730.
DR GeneID; 102285966; -.
DR KEGG; bom:102285966; -.
DR CTD; 60386; -.
DR OrthoDB; 261981at2759; -.
DR Proteomes; UP000011080; Unassembled WGS sequence.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:Ensembl.
DR GO; GO:0090422; F:thiamine pyrophosphate transmembrane transporter activity; IEA:Ensembl.
DR GO; GO:0009229; P:thiamine diphosphate biosynthetic process; IEA:Ensembl.
DR Gene3D; 1.50.40.10; Mitochondrial carrier domain; 1.
DR InterPro; IPR002067; Mit_carrier.
DR InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR InterPro; IPR023395; Mt_carrier_dom_sf.
DR PANTHER; PTHR24089:SF59; MITOCHONDRIAL THIAMINE PYROPHOSPHATE CARRIER; 1.
DR PANTHER; PTHR24089; SOLUTE CARRIER FAMILY 25; 1.
DR Pfam; PF00153; Mito_carr; 3.
DR PRINTS; PR00926; MITOCARRIER.
DR SUPFAM; SSF103506; Mitochondrial carrier; 1.
DR PROSITE; PS50920; SOLCAR; 3.
PE 3: Inferred from homology;
KW Antiport {ECO:0000256|ARBA:ARBA00022449};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PROSITE-
KW ProRule:PRU00282}; Reference proteome {ECO:0000313|Proteomes:UP000011080};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|PROSITE-
KW ProRule:PRU00282};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU000488}.
FT REPEAT 13..106
FT /note="Solcar"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00282"
FT REPEAT 116..202
FT /note="Solcar"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00282"
FT REPEAT 214..309
FT /note="Solcar"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00282"
SQ SEQUENCE 318 AA; 35140 MW; E18D4582464FFDE7 CRC64;
MVGYDPKADD RDISNVEVAV AGSVSGLVTR VLISPLDVIK IRFQLQIERL SRSDPNAKYH
GILQAGRQIL QEEGPTAFWK GHIPAQLLSI GYGAVQFLSF EVLTELVHRA SVRDARDFSV
HFLCGGLSAC VATLAVHPVD VLRTRFAAQG EPRVYKTLRD AVVTMYRTEG PLVFYKGLNP
TLIAIFPYAG FQFSIYSSLK RAYEWALPAE GKKNGNFKNL LCGSGAGVIS KTLTYPLDLF
KKRLQVGGFE QARASFGQVR SYKGLLDCAG QVLREEGAQG CFKGLSPSLL KAALSTGLVF
FWYELFCNFF HHMRKADS
//
