ID L8HTC5_9CETA Unreviewed; 214 AA.
AC L8HTC5;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 1.
DT 24-JAN-2024, entry version 45.
DE SubName: Full=HemK methyltransferase family member 2 {ECO:0000313|EMBL:ELR47540.1};
GN ORFNames=M91_08989 {ECO:0000313|EMBL:ELR47540.1};
OS Bos mutus (wild yak).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=72004 {ECO:0000313|EMBL:ELR47540.1, ECO:0000313|Proteomes:UP000011080};
RN [1] {ECO:0000313|EMBL:ELR47540.1, ECO:0000313|Proteomes:UP000011080}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=yakQH1 {ECO:0000313|Proteomes:UP000011080};
RX PubMed=22751099; DOI=10.1038/ng.2343;
RA Qiu Q., Zhang G., Ma T., Qian W., Wang J., Ye Z., Cao C., Hu Q., Kim J.,
RA Larkin D.M., Auvil L., Capitanu B., Ma J., Lewin H.A., Qian X., Lang Y.,
RA Zhou R., Wang L., Wang K., Xia J., Liao S., Pan S., Lu X., Hou H., Wang Y.,
RA Zang X., Yin Y., Ma H., Zhang J., Wang Z., Zhang Y., Zhang D., Yonezawa T.,
RA Hasegawa M., Zhong Y., Liu W., Zhang Y., Huang Z., Zhang S., Long R.,
RA Yang H., Wang J., Lenstra J.A., Cooper D.N., Wu Y., Wang J., Shi P.,
RA Wang J., Liu J.;
RT "The yak genome and adaptation to life at high altitude.";
RL Nat. Genet. 44:946-949(2012).
CC -!- SIMILARITY: Belongs to the eukaryotic/archaeal PrmC-related family.
CC {ECO:0000256|ARBA:ARBA00006149}.
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DR EMBL; JH883041; ELR47540.1; -; Genomic_DNA.
DR RefSeq; XP_005907880.1; XM_005907818.1.
DR AlphaFoldDB; L8HTC5; -.
DR SMR; L8HTC5; -.
DR STRING; 72004.ENSBMUP00000005698; -.
DR Ensembl; ENSBMUT00000006615; ENSBMUP00000005698; ENSBMUG00000004487.
DR GeneID; 102272049; -.
DR KEGG; bom:102272049; -.
DR CTD; 29104; -.
DR OrthoDB; 124743at2759; -.
DR Proteomes; UP000011080; Unassembled WGS sequence.
DR GO; GO:0032991; C:protein-containing complex; IEA:Ensembl.
DR GO; GO:0140984; F:histone H4K12 methyltransferase activity; IEA:Ensembl.
DR GO; GO:0030792; F:methylarsonite methyltransferase activity; IEA:Ensembl.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0036009; F:protein-glutamine N-methyltransferase activity; IEA:Ensembl.
DR GO; GO:1904047; F:S-adenosyl-L-methionine binding; IEA:Ensembl.
DR GO; GO:0009007; F:site-specific DNA-methyltransferase (adenine-specific) activity; IEA:Ensembl.
DR GO; GO:0018872; P:arsonoacetate metabolic process; IEA:Ensembl.
DR GO; GO:0030307; P:positive regulation of cell growth; IEA:Ensembl.
DR GO; GO:0009404; P:toxin metabolic process; IEA:Ensembl.
DR GO; GO:0045815; P:transcription initiation-coupled chromatin remodeling; IEA:Ensembl.
DR CDD; cd02440; AdoMet_MTases; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR InterPro; IPR004557; PrmC-related.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR007848; Small_mtfrase_dom.
DR NCBIfam; TIGR00537; hemK_rel_arch; 1.
DR PANTHER; PTHR45875; METHYLTRANSFERASE N6AMT1; 1.
DR PANTHER; PTHR45875:SF1; METHYLTRANSFERASE N6AMT1; 1.
DR Pfam; PF05175; MTS; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS00092; N6_MTASE; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000313|EMBL:ELR47540.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000011080};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:ELR47540.1}.
FT DOMAIN 31..127
FT /note="Methyltransferase small"
FT /evidence="ECO:0000259|Pfam:PF05175"
SQ SEQUENCE 214 AA; 22930 MW; 4CD8AD8F2CE764CA CRC64;
MAAPSFPTPL HGHVGRGDFS DVYEPAEDTF LLLDALEAAA AELTGVEICL EVGSGSGVVS
AFLASVIGPQ ALYMCTDVNP EAAACTLETA RCNKVHIQPI ITDLVKGLLP RLKESVDLLV
FNPPYVVTPP EEVGSRGIQA AWAGGRNGRE VIDRFLPLAP DLLSPRGLFY LVTIKENNPE
EILKIMKTKG LQGTTVLSRQ AGQEMLSVLK FTKS
//
