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Database: UniProt
Entry: L8HTS0_9CETA
LinkDB: L8HTS0_9CETA
Original site: L8HTS0_9CETA 
ID   L8HTS0_9CETA            Unreviewed;       654 AA.
AC   L8HTS0;
DT   03-APR-2013, integrated into UniProtKB/TrEMBL.
DT   03-APR-2013, sequence version 1.
DT   24-JAN-2024, entry version 54.
DE   SubName: Full=RAS guanyl-releasing protein 4 {ECO:0000313|EMBL:ELR47283.1};
DE   Flags: Fragment;
GN   ORFNames=M91_17443 {ECO:0000313|EMBL:ELR47283.1};
OS   Bos mutus (wild yak).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=72004 {ECO:0000313|EMBL:ELR47283.1, ECO:0000313|Proteomes:UP000011080};
RN   [1] {ECO:0000313|EMBL:ELR47283.1, ECO:0000313|Proteomes:UP000011080}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=yakQH1 {ECO:0000313|Proteomes:UP000011080};
RX   PubMed=22751099; DOI=10.1038/ng.2343;
RA   Qiu Q., Zhang G., Ma T., Qian W., Wang J., Ye Z., Cao C., Hu Q., Kim J.,
RA   Larkin D.M., Auvil L., Capitanu B., Ma J., Lewin H.A., Qian X., Lang Y.,
RA   Zhou R., Wang L., Wang K., Xia J., Liao S., Pan S., Lu X., Hou H., Wang Y.,
RA   Zang X., Yin Y., Ma H., Zhang J., Wang Z., Zhang Y., Zhang D., Yonezawa T.,
RA   Hasegawa M., Zhong Y., Liu W., Zhang Y., Huang Z., Zhang S., Long R.,
RA   Yang H., Wang J., Lenstra J.A., Cooper D.N., Wu Y., Wang J., Shi P.,
RA   Wang J., Liu J.;
RT   "The yak genome and adaptation to life at high altitude.";
RL   Nat. Genet. 44:946-949(2012).
CC   -!- SIMILARITY: Belongs to the RASGRP family.
CC       {ECO:0000256|ARBA:ARBA00009566}.
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DR   EMBL; JH883137; ELR47283.1; -; Genomic_DNA.
DR   AlphaFoldDB; L8HTS0; -.
DR   STRING; 72004.ENSBMUP00000001964; -.
DR   Proteomes; UP000011080; Unassembled WGS sequence.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR   CDD; cd20863; C1_RASGRP4; 1.
DR   CDD; cd00155; RasGEF; 1.
DR   CDD; cd06224; REM; 1.
DR   Gene3D; 3.30.60.20; -; 1.
DR   Gene3D; 1.10.238.10; EF-hand; 1.
DR   Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR   Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR   InterPro; IPR046349; C1-like_sf.
DR   InterPro; IPR020454; DAG/PE-bd.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR002219; PE/DAG-bd.
DR   InterPro; IPR008937; Ras-like_GEF.
DR   InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR   InterPro; IPR023578; Ras_GEF_dom_sf.
DR   InterPro; IPR001895; RASGEF_cat_dom.
DR   InterPro; IPR036964; RASGEF_cat_dom_sf.
DR   PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR   PANTHER; PTHR23113:SF157; RAS GUANYL-RELEASING PROTEIN 4; 1.
DR   Pfam; PF00130; C1_1; 1.
DR   Pfam; PF00617; RasGEF; 1.
DR   PRINTS; PR00008; DAGPEDOMAIN.
DR   SMART; SM00109; C1; 1.
DR   SMART; SM00147; RasGEF; 1.
DR   SUPFAM; SSF57889; Cysteine-rich domain; 1.
DR   SUPFAM; SSF48366; Ras GEF; 1.
DR   PROSITE; PS50222; EF_HAND_2; 1.
DR   PROSITE; PS50009; RASGEF_CAT; 1.
DR   PROSITE; PS50212; RASGEF_NTER; 1.
DR   PROSITE; PS00479; ZF_DAG_PE_1; 1.
DR   PROSITE; PS50081; ZF_DAG_PE_2; 1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|ARBA:ARBA00022837};
KW   Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW   ECO:0000256|PROSITE-ProRule:PRU00168};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Reference proteome {ECO:0000313|Proteomes:UP000011080};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT   DOMAIN          28..153
FT                   /note="N-terminal Ras-GEF"
FT                   /evidence="ECO:0000259|PROSITE:PS50212"
FT   DOMAIN          182..413
FT                   /note="Ras-GEF"
FT                   /evidence="ECO:0000259|PROSITE:PS50009"
FT   DOMAIN          447..482
FT                   /note="EF-hand"
FT                   /evidence="ECO:0000259|PROSITE:PS50222"
FT   DOMAIN          521..571
FT                   /note="Phorbol-ester/DAG-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50081"
FT   REGION          143..169
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          574..599
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          619..654
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         654
FT                   /evidence="ECO:0000313|EMBL:ELR47283.1"
SQ   SEQUENCE   654 AA;  72566 MW;  07DBEF66C162F750 CRC64;
     GRPRQARRHK TCPSPREISK VMASMALGML NEGGCSEDEL LEKCIQSFDS AGSLRRGDHV
     LNMVLAMHSW VLPSAHFAAR LLTLYPPGAI SRSTQELRRL QICHLVRYWL AQHPETMHQD
     PQLEEVIGRF WATVEQEGNS VQQSLGDFSS RLSPGGPGPP HPMSSPGLGK KRKVSLLFDH
     LETGELAEHL TYLEFRSFQA ITPQDLRDYV LQGSVRGCPT LEGSVGLSNS VSRWVQVMVL
     SRPGPAQRAQ VLDKFIQVAQ KLLQLHNFNT LMAVTGGLCH SAISRLKDSH AHLSPDSTKA
     LLELTELLAA HNNYARYRRT WAGCMDFRLP VLGVHLKDLV ALNEAQPDRL PDGRLHLPKL
     NSLYLRLQEL AALQQQHPPG NASEDLLHLL TLSLDLFYTE DEIYELSYAR EPRCPKSLPP
     SPFKAPLVVE WAPGVTPKPD TVTLGRHVEQ LVESVFKNYD PDGRGTISQE DFERLSGNFP
     FACHGLHPPP CQGSGSFSRE ELTGYLLRAS AICSKLGLAF LHTFQEVTFR KPTFCNSCSG
     FLWGVTKQGY RCRDCGLCCH RHCRDQVKVE CKKRPGAKGD ASTPEAPVPP TPVPQASCGS
     EDNLSYTLSL EPETGCHVRH AWTQTESPHP SWEPETVPLP AKASPPTESS KLNS
//
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