ID L8HV55_9CETA Unreviewed; 851 AA.
AC L8HV55;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE RecName: Full=B-cell receptor CD22 {ECO:0000256|ARBA:ARBA00040106};
DE AltName: Full=Sialic acid-binding Ig-like lectin 2 {ECO:0000256|ARBA:ARBA00041781};
DE Flags: Fragment;
GN ORFNames=M91_17370 {ECO:0000313|EMBL:ELR47219.1};
OS Bos mutus (wild yak).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=72004 {ECO:0000313|EMBL:ELR47219.1, ECO:0000313|Proteomes:UP000011080};
RN [1] {ECO:0000313|EMBL:ELR47219.1, ECO:0000313|Proteomes:UP000011080}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=yakQH1 {ECO:0000313|Proteomes:UP000011080};
RX PubMed=22751099; DOI=10.1038/ng.2343;
RA Qiu Q., Zhang G., Ma T., Qian W., Wang J., Ye Z., Cao C., Hu Q., Kim J.,
RA Larkin D.M., Auvil L., Capitanu B., Ma J., Lewin H.A., Qian X., Lang Y.,
RA Zhou R., Wang L., Wang K., Xia J., Liao S., Pan S., Lu X., Hou H., Wang Y.,
RA Zang X., Yin Y., Ma H., Zhang J., Wang Z., Zhang Y., Zhang D., Yonezawa T.,
RA Hasegawa M., Zhong Y., Liu W., Zhang Y., Huang Z., Zhang S., Long R.,
RA Yang H., Wang J., Lenstra J.A., Cooper D.N., Wu Y., Wang J., Shi P.,
RA Wang J., Liu J.;
RT "The yak genome and adaptation to life at high altitude.";
RL Nat. Genet. 44:946-949(2012).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
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DR EMBL; JH883137; ELR47219.1; -; Genomic_DNA.
DR AlphaFoldDB; L8HV55; -.
DR STRING; 72004.ENSBMUP00000021841; -.
DR Proteomes; UP000011080; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR CDD; cd00096; Ig; 2.
DR Gene3D; 2.60.40.10; Immunoglobulins; 7.
DR InterPro; IPR013162; CD80_C2-set.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR PANTHER; PTHR46958; B-CELL RECEPTOR CD22; 1.
DR PANTHER; PTHR46958:SF1; B-CELL RECEPTOR CD22; 1.
DR Pfam; PF08205; C2-set_2; 1.
DR Pfam; PF13895; Ig_2; 2.
DR Pfam; PF13927; Ig_3; 2.
DR SMART; SM00409; IG; 7.
DR SMART; SM00408; IGc2; 5.
DR SUPFAM; SSF48726; Immunoglobulin; 7.
DR PROSITE; PS50835; IG_LIKE; 6.
PE 4: Predicted;
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000313|EMBL:ELR47219.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000011080};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 690..708
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 152..235
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 247..328
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 335..418
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 423..503
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 508..588
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 595..678
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ELR47219.1"
SQ SEQUENCE 851 AA; 95552 MW; B44D25039308BEE2 CRC64;
STMHLLGPSL LLLGKDGSLE YLTFSDSAWN FRHPKTLYAW DGACVWIPCT YSSVKGGGHT
LDNLTVYHNF TYDKKTKHYN GTILYNKSLK TKESTPSQER VQFLGNNRNN CTLLINPVKV
NDSGLLGLRV TSGTDKWMAS LNLSISESAP QPHIELHQEI REDQEVTVTC SLNFACRDYQ
VHLQWSLEGS VTTSTILSPE MVTTQSHLSF QPKWTHDGKN LTCQLWDPMK QRILSEKTVL
LEVKHAPKLE IQVSPQEAIV TEGESVTMRC QVISSNPPHW SVSWFKDRTK LKEEGTTLVL
PEVTRTMSGQ YTCQVSNDVG SRQSDVVDLQ VHYPPEPSWV QLSPSSIKEG VTVELTCMSV
ANPPPANYTW YFNEQEIPGK NGRTFQIPQV LVKHAGRYSC LAENSLGPGS VDREADLNVQ
YPPKGVTTVI QNPTPIREGD SVTLSCTFNS SNPRVTRYNW NSPGSQDHTS QKLTIQKVTW
DAQPVKCEAC NQWCSWSPSV NLNVLYAPRD VNIQISPNTE IQSEKRVLLQ CQYSSSRPAD
VHFFWKKDGS LLKEGKTLTF GQIFPEDSGT YHCLVNNSIG QTSSKAYELQ VLYAPRRLRV
SISPKDGVVE GKTAVLTCES DANPPISHYD WFDGKNQDLH YYGQMLRLEP VKLQHAGSYW
CRGTNRLGQS QSPPTTLTVY YSAATISRRA ALGVGFCLAI FLLAIWGVKL QRSWKRIQRQ
QGLQESSSGQ SFFVRNLKAR RTPQAERPAS LGCYNPVMED AVSYATLSFP LGETDTRRLR
DAGSSEMREI PPSREDRVTY AVVQNCQVAD YENVTPEVLD DEGIHYSELV HFGNGKRALA
QEGVEYVTLK H
//
