ID L8HVC7_9CETA Unreviewed; 803 AA.
AC L8HVC7;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE SubName: Full=Epidermal growth factor receptor kinase substrate 8 {ECO:0000313|EMBL:ELR47823.1};
DE Flags: Fragment;
GN ORFNames=M91_21458 {ECO:0000313|EMBL:ELR47823.1};
OS Bos mutus (wild yak).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=72004 {ECO:0000313|EMBL:ELR47823.1, ECO:0000313|Proteomes:UP000011080};
RN [1] {ECO:0000313|EMBL:ELR47823.1, ECO:0000313|Proteomes:UP000011080}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=yakQH1 {ECO:0000313|Proteomes:UP000011080};
RX PubMed=22751099; DOI=10.1038/ng.2343;
RA Qiu Q., Zhang G., Ma T., Qian W., Wang J., Ye Z., Cao C., Hu Q., Kim J.,
RA Larkin D.M., Auvil L., Capitanu B., Ma J., Lewin H.A., Qian X., Lang Y.,
RA Zhou R., Wang L., Wang K., Xia J., Liao S., Pan S., Lu X., Hou H., Wang Y.,
RA Zang X., Yin Y., Ma H., Zhang J., Wang Z., Zhang Y., Zhang D., Yonezawa T.,
RA Hasegawa M., Zhong Y., Liu W., Zhang Y., Huang Z., Zhang S., Long R.,
RA Yang H., Wang J., Lenstra J.A., Cooper D.N., Wu Y., Wang J., Shi P.,
RA Wang J., Liu J.;
RT "The yak genome and adaptation to life at high altitude.";
RL Nat. Genet. 44:946-949(2012).
CC -!- SIMILARITY: Belongs to the EPS8 family.
CC {ECO:0000256|ARBA:ARBA00006197}.
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DR EMBL; JH882953; ELR47823.1; -; Genomic_DNA.
DR AlphaFoldDB; L8HVC7; -.
DR STRING; 72004.ENSBMUP00000007871; -.
DR Proteomes; UP000011080; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd01210; PTB_EPS8; 1.
DR CDD; cd09540; SAM_EPS8-like; 1.
DR CDD; cd11764; SH3_Eps8; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 1.
DR InterPro; IPR039801; EPS8-like.
DR InterPro; IPR033928; EPS8_PTB.
DR InterPro; IPR035462; Eps8_SH3.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR013625; PTB.
DR InterPro; IPR006020; PTB/PI_dom.
DR InterPro; IPR013761; SAM/pointed_sf.
DR InterPro; IPR041418; SAM_3.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR12287:SF21; EPIDERMAL GROWTH FACTOR RECEPTOR KINASE SUBSTRATE 8; 1.
DR PANTHER; PTHR12287; EPIDERMAL GROWTH FACTOR RECEPTOR KINASE SUBSTRATE EPS8-RELATED PROTEIN; 1.
DR Pfam; PF08416; PTB; 1.
DR Pfam; PF18016; SAM_3; 1.
DR Pfam; PF00018; SH3_1; 1.
DR SMART; SM00462; PTB; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50002; SH3; 1.
PE 3: Inferred from homology;
KW Kinase {ECO:0000313|EMBL:ELR47823.1};
KW Receptor {ECO:0000313|EMBL:ELR47823.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000011080};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}; Transferase {ECO:0000313|EMBL:ELR47823.1}.
FT DOMAIN 512..571
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 188..207
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 282..303
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 448..467
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 597..670
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 190..204
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 448..462
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 601..627
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 632..655
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 656..670
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ELR47823.1"
FT NON_TER 803
FT /evidence="ECO:0000313|EMBL:ELR47823.1"
SQ SEQUENCE 803 AA; 89439 MW; 714E1EC4FA8D08C5 CRC64;
SGYGSSATFS MDRDHSSRTS AKALYEQRKN YARDSVSSVS DISQYRVEHL TTFVLDRKDA
MITVDDGIRK LKLLDAKGKV WTQDMILQVD EKAVSLIDLE SKASSQNELE NFPLNTIQHC
QAVMHSCSYD SILALVCKEP TQSKPDLHLF QCDEIKANLI SEDVESAISD SKGGKQKRRL
DVLRMISKAD PGIPPPPKAP APVPPGTVTQ VDVRSRVAAW SALAADQADF EKQRNYYQQE
ETPEMMAARI DRDVQILNHI LDDIEFFITK LQKAAEAFSE LSKRKKAKKG KKKGPGEGVL
TLRAKPPPPD AFVDCFQKFK HGFNLLAKLK SHIQNPSAAD LVHFLFTPLN MVVQATGGPE
LAGSVLSPLL TKDTIDFLNY TVSADERQLW MSLGDSWMKT RAEWPKEQFI PPYVPRFRSG
WEPPMLNFMG SSVEPDLYQL NESVANAAEH HRKQETKRLS TEHSSVSEYP SADGYTAFNN
IYGRGPHSDQ GEAAVAFKPT PLRHVDRNYD LQPKKYAKSK YDFVARNNSE LSVQKDDILE
ILDDRKQWWK VRNASGDSGF VPNNILDIVR PPESGLGRAD PPYTHTIQKQ RMEYGPRATD
IPSAPSPPPT PAPVPVPLPP STPAPIPVSK LPANITRQNS SSSDSGGSIV RDSQRQKQVP
VDRRKSQMEE VQDELIHRLT IGRSAAQKKF HVPRQNVPVV NITYDSTPEE VKTWLQSKGF
NPVTVNSLGV LNGAQLFSLN KDELRTVCPE GARVFSQITV QKAALEDNSG SSELQEIMRR
RQEKISAAAS DSGVESFDEG SIT
//
